AI Summary & Key Takeaways
AI InsightNT-proBNP was also related to the disulphide level.The left ventricular ejection fraction (LVEF) and the levels ofnative thiol, total thiol, low-density lipoprotein, and serum albumin were found to be independent predictors of major adversecardiovascular events (MACEs) during 6 months of follow-up.Conclusion: Initial lower native thiol, total thiol, LVEF, LDL,and serum albumin may be used to identify patients with anincreased long-term risk of unfavorable cardiac events in caseof STEMI.
📌 3 Key Takeaways
Abstract
Objective: The aim of this study was to investigate whetherlow thiol levels are associated with peri-procedural factorsduring primary percutaneous coronary intervention (pPCI)upon admission with ST-segment elevation myocardial infarction (STEMI), and the prognostic value at 6-month follow-up.Methods: A total of 241 consecutive acute STEMI patientswho underwent pPCI and a control group of 67 individuals witha normal coronary angiography were enrolled in the study.Results: While age, contrast-induced nephropathy, N-terminalprohormone of brain natriuretic peptide (NT-proBNP), stentlength, and creatinine were related to native thiol, NT-proBNP,contrast-induced nephropathy, and creatinine were related tototal thiol. NT-proBNP was also related to the disulphide level.The left ventricular ejection fraction (LVEF) and the levels ofnative thiol, total thiol, low-density lipoprotein, and serum albumin were found to be independent predictors of major adversecardiovascular events (MACEs) during 6 months of follow-up.Conclusion: Initial lower native thiol, total thiol, LVEF, LDL,and serum albumin may be used to identify patients with anincreased long-term risk of unfavorable cardiac events in caseof STEMI.
Özet
Amaç: Bu çalışmanın amacı, primer perkütan koroner girişim yapılan ST-segment yükselmeli miyokart enfarktüsü (STEMI) hastalarında periprosedürel faktörlerle düşük tiyol seviyelerinin ilişkisi olup olmadığını ve 6 aylık takipte prognoza etkilerini belirlemektir. Yöntemler: Primer perkütan koroner girişim yapılan 241 STEMI ve normal koroner anjiyografi saptanan 67 bireyden oluşan kontrol grubu dahil edildi. Bulgular: Yaş, kontrast nefropatisi, N-terminal beyin natriüretik peptit (NT-proBNP), stent uzunluğu ve kreatinin native thiol için, NT-proBNP, kontrast nefropatisi ve kreatinin total tiyol ile ilişkili faktörler iken; NT-proBNP disülfit ile ilşkili faktör olarak saptandı. Sol ventrikül ejeksiyon fraksiyonu, nativ tiyol, total tiyol, düşük yoğunluklu lipoprotein (LDL) ve serum albümin altı aylık majör istenmeyen kardiyovasküler olaylar (MACE) gelişimine etki eden en etkili parametreler olarak bulundu. Sonuç: ST-segment yükselmeli miyokart enfarktüs hastalarında sol ventrikül ejeksiyon fraksiyonu, nativ, total tiyol, LDL ve serum albümin uzun dönem morbititeye etki eden faktörler olarak değerlendirilebilir.