Disseminated adenovirus infection in heart and kidney transplant

Objective & Hypothesis:Presently described is a case of disseminatedadenovirus infection in a heart-kidney transplant recipientthat was successfully treated with cidofovir.

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Key Findings & Data:There areseveral reports of adenovirus infections in adult solid organtransplant recipients and the prognosis is usually poor, withmortality rates of 40% to 60%.

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Conclusion & Impact:Early diagnosis and treatment are criticalto improving outcomes in immunocompromised patients

🔬Design:Research Article

📍Scope:Comprehensive Sample

⚙️Variables:Domain Parameters

Abstract

Presently described is a case of disseminatedadenovirus infection in a heart-kidney transplant recipientthat was successfully treated with cidofovir. There areseveral reports of adenovirus infections in adult solid organtransplant recipients and the prognosis is usually poor, withmortality rates of 40% to 60%. Severe disseminated adenovirusinfections have been associated with increased riskof adverse transplant events, such as rejection, ventriculardysfunction, allograft vasculopathy, graft loss, and the needfor re-transplantation. The patient’s lack of clinical improvement,the onset of hemorrhagic cystitis and acute kidney injurywere factors in our decision to temporarily discontinueadministration of immunosuppressive agents and start anantiviral agent. It is important to suspect adenovirus in transplantpatients when they do not respond to antibiotics andcultures are negative. Early diagnosis and treatment are criticalto improving outcomes in immunocompromised patients

Özet

Burada sidofovir ile başarıyla tedavi edilen bir kalpböbrek alıcısında yaygın adenovirüs enfeksiyonu olgusunu tanımlıyoruz. Erişkin solid organ transplant alıcılarında prognozu genellikle kötü, ölüm oranları %40–60 arası birkaç adenovirüs enfeksiyonu olgusu bildirilmiştir. Ağır yaygın adenovirüs enfeksiyonları organ rejeksiyon, ventrikül işlev bozukluğu allogreft vaskülopatisi, greft kaybı ve yeniden transplantasyon gerekliliği gibi giderek artan olumsuz transplant olayları riskiyle ilişkilendirilmiştir. Hastada klinik iyileşmemenin olmaması, hemorajik sistit başlangıcı ve akut böbrek hasarı geçici olarak bağışıklık sistemini baskılayıcı ilaçların uygulanmasını durdurup bir antiviral ilaca başlama kararımıza etkili faktörler olmuştur. Antibiyotiklere yanıt vermedikleri ve kültürlerin negatif olduğu durumlarda transplant hastalarında adenovirüsten kuşkulanılması önemlidir. Bağışıklık sistemi risk altında olan hastalarda sonuçları iyileştirmede erken tanı ve tedavi önem taşır

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Cite This Article

Xu, J., Patel, K. V., Dsouza, M., Almendral, J., Mody, K., Iyer, D. (2022). Disseminated adenovirus infection in heart and kidney transplant. Türk Kardiyoloji Derneği Arşivi, Cilt: 46 - Sayı: 3, 231–233. https://ajindex.com/articles/632123

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