Role of polymorphisms of the endothelial nitric oxide synthase gene in predicting slow-flw phenomenon after primary percutaneous coronary intervention

In theadjusted analysis, the -786T>C polymorphism did not reachstatistical signifiance.Conclusion: There was no signifiant association betweenCSFP and 2 of the most common polymorphisms of theeNOS gene in post-PPCI patients.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: The aim of the present study was to examinethe association between 2 polymorphisms of the endothelialnitric oxide (eNOS) gene (-786T>C and +894G>T) and theno-reflw/slow-flw phenomenon in post-primary percutaneous coronary intervention (PPCI) patients.Methods: A total of 103 post-PPCI patients were enrolled.Coronary no-reflw phenomenon was defied as a Thrombolysis in Myocardial Infarction (TIMI) flw grade 0–1 andcoronary slow-flw phenomenon (CSFP) was defied as aTIMI flw grade ≤2.Results: Due to the small number of post-PPCI patients withthe no-reflw phenomenon (n=4), the primary comparisonwas made between CSFP (n=20) and normal flw (n=83)groups.

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Key Findings & Data:There was a greater frequency of CSFP amongcarriers of the –786C allele of the eNOS –786T>C polymorphism (odds ratio [OR]: 3.90; 95% confience interval [CI]:0.87–17.45; p=0.07).

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Conclusion & Impact:In theadjusted analysis, the -786T>C polymorphism did not reachstatistical signifiance.Conclusion: There was no signifiant association betweenCSFP and 2 of the most common polymorphisms of theeNOS gene in post-PPCI patients.

🔬Design:Research Article

📍Scope:Comprehensive Sample

⚙️Variables:Domain Parameters

Abstract

Objective: The aim of the present study was to examinethe association between 2 polymorphisms of the endothelialnitric oxide (eNOS) gene (-786T>C and +894G>T) and theno-reflw/slow-flw phenomenon in post-primary percutaneous coronary intervention (PPCI) patients.Methods: A total of 103 post-PPCI patients were enrolled.Coronary no-reflw phenomenon was defied as a Thrombolysis in Myocardial Infarction (TIMI) flw grade 0–1 andcoronary slow-flw phenomenon (CSFP) was defied as aTIMI flw grade ≤2.Results: Due to the small number of post-PPCI patients withthe no-reflw phenomenon (n=4), the primary comparisonwas made between CSFP (n=20) and normal flw (n=83)groups. There was a greater frequency of CSFP amongcarriers of the –786C allele of the eNOS –786T>C polymorphism (odds ratio [OR]: 3.90; 95% confience interval [CI]:0.87–17.45; p=0.07). However, no such association wasdetected between the +894T allele of the eNOS +894G>Tand CSFP (OR: 0.92; 95% CI: 0.21–3.98; p=0.91). In theadjusted analysis, the -786T>C polymorphism did not reachstatistical signifiance.Conclusion: There was no signifiant association betweenCSFP and 2 of the most common polymorphisms of theeNOS gene in post-PPCI patients.

Özet

Amaç: Bu çalışmada, primer perkütan koroner girişim (PPKG) yapılan hastalarda endotelyal nitrik oksit (eNOS) geninin (-786T>C ve +894G>T) iki polimorfimi ile akımsızlık /yavaş akım fenomeninin ilişkisini araştırmayı amaçladık. Yöntemler: PPKG sonrası toplam 103 hasta çalışmaya dahil edildi. Koroner akımsızlık fenomeni miyokart enfarktüsünde tromboliz (TIMI) akım derecesi 0–1, koroner yavaş akım fenomeni (KYAF) ise TIMI akım derecesi ≤2 olarak tanımlandı. Bulgular: PPKG sonrasında akımsızlık gelişen hasta sayı- sının azlığı (n=4) nedeniyle, ana karşılaştırma KYAF (n=20) ve normal akım (n=83) grupları arasında yapıldı. eNOS –786T>C polimorfiminin –786C aleli taşıyıcıları, daha yüksek sıklıkta KYAF’a sahip olma eğilimi gösterdi (OR: 3.90, %95 GA: 0.87–17.45; p=0.07). Bununla birlikte, eNOS +894G>T ve KYAF’nin +894T aleli için böyle bir ilişki saptanmadı (OR: 0.92, %95 GA: 0.21–3.98; p=0.91). Düzeltilmiş analizde, ayarlamalar yapıldıktan sonra -786T> C polimorfimi istatistiksel öneme ulaşmadı. Sonuç: PPKG sonrası hastalarımızda KYAF ile eNOS geninin en sık görülen polimorfimlerinden ikisi arasında anlamlı bir ilişki bulamadık.

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Cite This Article

RAFATNİA, S., KİANİ, R., FİROUZİ, A., RAHİMİ, S., ZAHEDMEHR, A., MEHRVARZ, F., MAHARİ, M. M., HAMEDİSERESHT, M., SADEGHİPOUR, P., ALİLOU, S., TASLİMİ, Y., HABİBZADEH, S., RAFATİ, S., GHARİBZADEH, S. (2022). Role of polymorphisms of the endothelial nitric oxide synthase gene in predicting slow-flw phenomenon after primary percutaneous coronary intervention. Türk Kardiyoloji Derneği Arşivi, Cilt: 48 - Sayı: 5, 472–483. https://ajindex.com/articles/632005

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