Journals / Türk Kardiyoloji Derneği Arşivi / 2020 / Cilt: 48 - Sayı: 2

Evaluation of the relationship between platelet indices and spontaneous echo contrast in patients with mitral prosthetic heart valves

Mitral protez kalp kapaklı hastalarda trombosit indeksleri ile spontan eko kontrast arasındaki ilişkinin araştırılması

Pages
127–136
Publication Date
2022-11-05
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Therefore, the use ofplatelet indices alongside known echocardiographic and clinical risk factors to predict SEC development in patients with amitral prosthesis is debatable.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Spontaneous echo contrast (SEC) is defined asdynamic, smoke-like echoes within the cardiac cavities with acharacteristic swirling motion seen on echocardiography.
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Key Findings & Data:Clinical studies have demonstrated that SEC is a risk factor for leftatrial thrombus formation and an important indicator for potential systemic embolism.
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Conclusion & Impact:Therefore, the use ofplatelet indices alongside known echocardiographic and clinical risk factors to predict SEC development in patients with amitral prosthesis is debatable.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: Spontaneous echo contrast (SEC) is defined asdynamic, smoke-like echoes within the cardiac cavities with acharacteristic swirling motion seen on echocardiography. Clinical studies have demonstrated that SEC is a risk factor for leftatrial thrombus formation and an important indicator for potential systemic embolism. Platelet indices have been associatedwith the presence of SEC in patients with mitral stenosis. Theaim of this study was to investigate the relationship betweenplatelet indices and SEC in patients with prosthetic heart valves.Methods: A total of 89 patients [female: 38 (42.4%); medianage: 52 years (range: 36-67 years)] with SEC formation in theleft atrium, and 257 control subjects [female: 123 (47.5%); median age: 56 years (range: 45-65 years)] without SEC formation were enrolled. All of the patients were evaluated by usingtransthoracic and transesophageal echocardiography. Laboratory tests including complete blood count and biochemical parameters were analyzed.Results: Patients with SEC formation had more frequentatrial fibrillation, higher left atrial diameter (LAD) and lower leftventriular ejection fraction values. Platelet indices includingplatelet count, platelet distribution width, mean platelet volume,and plateletcrit did not differ between the groups. IncreasedLAD was detected as the only independent predictor of SECdevelopment.Conclusion: Platelet indices were not found to be associatedwith the presence of SEC formation in the left atrium amongpatients with mitral prosthetic valves. Therefore, the use ofplatelet indices alongside known echocardiographic and clinical risk factors to predict SEC development in patients with amitral prosthesis is debatable.

Özet

Amaç: Spontan eko kontrast (SEK) ekokardiyografi ile kalp boşluklarında karakteristik girdapsı hareketi olan dinamik duman benzeri yansımalar olarak tanımlanmaktadır. Önceki klinik çalışmalar SEK mevcudiyetini sol atriyal trombüs gelişimi için bir risk faktörü ve olası sistemik embolizm için önemli bir gösterge olduğunu kanıtlamıştır. Mitral stenozu olan hastalarda SEK varlığı ile trombosit indeksleri arasındaki ilişki gösterilmiştir. Bu çalışmada mekanik protez kapaklı hastalarda trombosit indeksleri ve SEK arasındaki ilişkinin araştırılması amaçlanmıştır. Yöntemler: Bu kilinik çalışmaya sol atriyumda SEK formasyonu izlenen 89 hasta [kadın: 38 (%42.4), ortalama yaş: 52 (36- 67) yıl ] ve SEK formasyonu izlenmeyen 257 kişiden oluşan kontrol grubu [kadın: 123 (%47.5), ortalama yaş: 56 (45-65) yıl] dahil edildi. Tüm hastalar transtorasik ve transözafajiyal ekokardiyografinin yanında tam kan sayımı ve biyokimyasal parametrelerinin olduğu labaratuvar testleri ile değerlendirildi. Bulgular: SEK formasyonuna sahip hastalarda daha sık atriyal fibrilasyon, daha geniş sol atriyal çap ve daha az sol ventrikül ejeksiyon fraksiyonu izlendi. Trombosit sayısı, trombosit dağılım genişliği, ortalama trombosit hacmi ve pletaletkritten oluşan trombosit indeksleri açısından iki grup arasında farklılık izlenmedi. Artmış sol atriyum çapı SEK formasyonunun tek bağımsız öngörücüsü olarak belirlendi. Sonuç: Mitral mekanik protez kapaklı hastalarda sol atriyumda SEK formasyonu ile trombosit indeksleri arasında bir ilişki bulunamadı. Bu nedenle, trombosit indekslerinin daha önceden bilinen ekokardiyografik ve klinik risk faktörleri ile birlikte mitral protez kapaklı hastalarda SEK formasyonunun öngörüsünde kullanımı tartışmalıdır.

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Cite This Article

ÖZKAN, M., GÜNDÜZ, S., CERŞİT, S., GÜNER, A., BAYRAM, E., KARAKOYUN, S., YESİN, M., KALKAN, S., GÜRSOY, M. O., KALÇIK, M. (2022). Evaluation of the relationship between platelet indices and spontaneous echo contrast in patients with mitral prosthetic heart valves. Türk Kardiyoloji Derneği Arşivi, Cilt: 48 - Sayı: 2, 127–136. https://ajindex.com/articles/631960

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