SavedAdd your journal

Journals / Türk Kardiyoloji Derneği Arşivi / 2022 / Cilt: 50 - Sayı: 1

Impact of metabolic syndrome and systemic inflammation on endothelial function in postmenopausal women

Postmenopozal kadınlarda metabolik sendrom ve sistemik inflamasyonun endotel fonksiyonu üzerindeki etkisi

Tao SUN
Hongju ZHANG
Yutong CHENG
Jing ZHANG
HaiXia ZHANG
Chayakrit KRITTANAWONG
Edward El-AM
Roukoz Abou KARAM
Su WANG
Qian WANG
Ning MA
Pages
57–65
Publication Date
2022-11-06
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Compared to the group without MetS, patients with MetS had significantly lower natural logarithmic RHI (0.66±0.29 versus 0.91±0.31; p

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: Data on the impact of metabolic syndrome (MetS) and systemic inflammation on endothelial function remains scarce.
📊
Key Findings & Data:Methods: We identified 423 postmenopausal women from February 2019 through July 2020.
💡
Conclusion & Impact:Compared to the group without MetS, patients with MetS had significantly lower natural logarithmic RHI (0.66±0.29 versus 0.91±0.31; p
🔬Design:Research Article
📍Scope:2019 Verileri
⚙️Variables:Domain Parameters

Abstract

Objective: Data on the impact of metabolic syndrome (MetS) and systemic inflammation on endothelial function remains scarce. In this study, we aimed to investigate the combined effects of MetS and systemic inflammation on endothelial function in postmenopausal women. Methods: We identified 423 postmenopausal women from February 2019 through July 2020. MetS was diagnosed according to the International Diabetes Federation (IDF) criteria, and high sensitivity C-reaction protein (hs-CRP) was measured to assess the degree of underlying inflammation. The measurement of endothelial function was using digital arterial tonometry by assessing reactive hyperemia-induced vasodilation in one arm and adjusting for changes in the contralateral arm (reactive hyperemia index, RHI). Results: There were 156 patients with MetS and 267 without MetS. Compared to the group without MetS, patients with MetS had significantly lower natural logarithmic RHI (0.66±0.29 versus 0.91±0.31; p

Özet

Amaç: Metabolik sendromun (MetS) ve sistemik inflamasyonun endotelyal fonksiyon üzerindeki etkisine ilişkin veriler yetersizdir. Bu çalışmada, postmenopozal kadınlarda MetS ve sistemik inflamasyonun endotel fonksiyonu üzerindeki kombine etkilerini araştırmayı amaçladık. Yöntemler: Şubat 2019 ile Temmuz 2020 arasında 423 postmenopozal kadın belirlendi. MetS, Uluslararası Diyabet Federasyonu (IDF) kriterlerine göre teşhis edildi ve altta yatan inflamasyonun derecesini değerlendirmek için yüksek hassasiyetli C-reaksiyon proteini (hs-CRP) ölçüldü. Endotel fonksiyonunun ölçümü, bir kolda reaktif hipereminin neden olduğu vazodilatasyonu değerlendirerek ve karşı koldaki değişiklikleri (reaktif hiperemi indeksi, RHI) ayarlayarak dijital arteriyel tonometri kullanılarak yapıldı. Bulgular: MetS’li 156 ve MetS’siz 267 hasta vardı. MetS’i olmayan grupla karşılaştırıldığında, MetS’li hastalarda anlamlı olarak daha düşük doğal logaritmik RHI (0.66±0.29’a karşı 0.91±0.31; p

🔖

Cite This Article

SUN, T., ZHANG, H., CHENG, Y., ZHANG, J., ZHANG, H., KRITTANAWONG, C., El-AM, E., KARAM, R. A., WANG, S., WANG, Q., MA, N. (2022). Impact of metabolic syndrome and systemic inflammation on endothelial function in postmenopausal women. Türk Kardiyoloji Derneği Arşivi, Cilt: 50 - Sayı: 1, 57–65. https://ajindex.com/articles/631815

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (12)

  1. Choi BJ, Matsuo Y, Aoki T, Kwon TG, Prasad A, Gulati R, et al. Coronary endothelial dysfunction is associated with inflammation and vasa vasorum proliferation in patients with early atherosclerosis. Arterioscler Thromb Vasc Biol 2014
  2. [Crossref] 2. Grandl G, Wolfrum C. Hemostasis, endothelial stress, inflammation, and the metabolic syndrome. Semin Immunopathol 2018
  3. [Crossref] 3. Samsamshariat SZA, Sakhaei F, Salehizadeh L, Keshvari M, Asgary S. Relationship between resistin, endothelin-1, and flow-mediated dilation in patient with and without metabolic syndrome. Adv Biomed Res 2019
  4. [Crossref] 4. Brant LC, Wang N, Ojeda FM, LaValley M, Barreto SM, Benjamin EJ, et al. Relations of metabolically healthy and unhealthy obesity to digital vascular function in three community-based cohorts: a meta-analysis. J Am Heart Assoc 2017
  5. e004199. [Crossref] 5. Moore JX, Chaudhary N, Akinyemiju T. metabolic syndrome prevalence by race/ethnicity and sex in the United States, National Health and Nutrition Examination Survey, 1988-2012. Prev Chronic Dis 2017
  6. E24. [Crossref] 6. Hotamisligil GS. Inflammation and metabolic disorders. Nature 2006
  7. [Crossref] 7. Safranow K, Dziedziejko V, Rzeuski R, Czyzycka E, Bukowska H, Wojtarowicz A, et al. Inflammation markers are associated with metabolic syndrome and ventricular arrhythmia in patients with coronary artery disease. Postepy Hig Med Dosw (Online) 2016
  8. [Crossref] 8. Nishimura S, Manabe I, Nagasaki M, Seo K, Yamashita H, Hosoya Y, et al. In vivo imaging in mice reveals local cell dynamics and inflammation in obese adipose tissue. J Clin Invest 2008
  9. [Crossref] 9. Cleuren AC, Blankevoort VT, van Diepen JA, Verhoef D, Voshol PJ, Reitsma PH, et al. Changes in dietary fat content rapidly alters the mouse plasma coagulation profile without affecting relative transcript levels of coagulation factors. PloS One 2015
  10. e0131859. [Crossref] 10. Prasad M, Matteson EL, Herrmann J, Gulati R, Rihal CS, Lerman LO, et al. Uric acid is associated with inflammation, coronary microvascular dysfunction, and adverse outcomes in postmenopausal women. Hypertension 2017
  11. [Crossref] 11. Shin W, Kim SE, Lee JY, Seo JW, Hyun HS, Suh JH, et al. The effects of menopausal hormone therapy on serum level of C-reactive protein in postmenopausal Korean women. J Menopausal Med 2019
  12. [Crossref] 12. De Bandt JP, Monin C. Obesity, Nutrients and the immune system in the era of COVID