Journals / Türk Kardiyoloji Derneği Arşivi / 2022 / Cilt: 50 - Sayı: 5

The Relationships Between Chocolate Consumption and Endothelial Dysfunction in Patients with Heart Failure

Kalp Yetmezliği Hastalarında Çikolata Tüketimi ile Endotel Disfonksiyonu Arasındaki İlişkinin Belirlenmesi

Pages
334–339
Publication Date
2022-11-06
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Dark chocolate consumption also seems to improve endothelial functions by increasing flow-mediated dilation values.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: Dietary recommendations, in addition to medications, have recently become important in the treatment of heart failure.
📊
Key Findings & Data:We recorded the patients' 6-minute walking tests, flowmediated dilatation values, plasma catechin, epicatechin, and N-terminal pro-brain natriuretic peptide values before and after chocolate consumption.
💡
Conclusion & Impact:Dark chocolate consumption also seems to improve endothelial functions by increasing flow-mediated dilation values.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: Dietary recommendations, in addition to medications, have recently become important in the treatment of heart failure. Our study aimed to show the positive effects of both milk chocolate and dark chocolate on heart failure through endothelial functions. Methods: Twenty patients with heart failure and reduced ejection fraction were included in the study. In this randomized, crossover study, some of the patients consumed milk chocolate and some consumed dark chocolate. We recorded the patients' 6-minute walking tests, flowmediated dilatation values, plasma catechin, epicatechin, and N-terminal pro-brain natriuretic peptide values before and after chocolate consumption. After 2 weeks, their chocolate consumption was changed. The same parameters were measured again. Results: A significant decrease was observed in N-terminal pro-brain natriuretic peptide values after consumption of both milk chocolate (356 ± 54.2 and 310 ± 72.1 pg/mL; P = .007) and dark chocolate (341 ± 57 and 301 ± 60.1 pg/mL;P = .028). Flow-mediated dilation values increased after dark chocolate consumption (8.9 ± 3% and 14 ± 4.5%; P = .019). Conclusion: Chocolate consumption acutely decreases N-terminal pro-brain natriuretic peptide values in heart failure. Dark chocolate consumption also seems to improve endothelial functions by increasing flow-mediated dilation values.

Özet

Amaç: Son zamanlarda kalp yetmezliği tedavisinde ilaçlara ek olarak diyet önerileri de önem kazanmıştır. Bu çalışmanın amacı; hem sütlü çikolatanın, hem de bitter çikolatanın kalp yetersizliği üzerindeki olumlu etkilerini endotel fonksiyonları üzerinden göstermektir. Yöntemler: Çalışmaya düşük ejeksiyon fraksiyonlu kalp yetmezliği tanısı ile takip edilen yirmi hasta dahil edildi. Randomize cross-over olarak tasarlanan çalışmada hastaların bir kısmı sütlü, bir kısmı da bitter çikolata tüketti. Hastaların çikolata tüketimi öncesi ve sonrası 6 dakikalık yürüme testi sonuçları, akım aracılı dilatasyon değerleri, plazma kateşin, epikateşin ve NT pro BNP değerleri kaydedildi. İki hafta sonra hastaların tükettikleri çikolata tipleri değiştirildi. Aynı parametreler tekrar ölçüldü. Bulgular: Hem sütlü çikolata (356 ± 54,2, 310 ± 72,1 pg/mL; P = ,007) hem de bitter çikolata (341 ± 57,301 ± 60,1 pg/mL; P = ,028) tüketiminden sonra NT pro BNP değerlerinde anlamlı bir düşüş gözlendi. Bitter çikolata tüketiminden sonra FMD değerlerinde anlamlı artış izlendi (%8,9 ± 3, %14 ± 4,5; P = ,019). Sonuç: Çikolata tüketimi kalp yetersizliğinde NT proBNP değerlerini anlamlı bir şekilde düşürmektedir. Bitter çikolata tüketimi de kalp yetersizliği hastalarında FMD değerlerini artırarak endotel fonksiyonlarını iyileştiriyor gibi görünmektedir.

🔖

Cite This Article

DURAL, İ. E., ONRAT, E., ÇELİK, S., VURMAZ, A., YALIM, Z., GÖKASLAN, S., GÖKASLAN, Ç., KORUCU, C., AKSU, U. (2022). The Relationships Between Chocolate Consumption and Endothelial Dysfunction in Patients with Heart Failure. Türk Kardiyoloji Derneği Arşivi, Cilt: 50 - Sayı: 5, 334–339. https://ajindex.com/articles/631808

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (15)

  1. Fazekas F, Gattringer T, Enzinger C. Cerebrovascular Disorders. Current Opinion in Neurology. Philadelphia
  2. Lippincott Williams and Wilkins
  3. [CrossRef] 2. Magrone T, Russo MA, Jirillo E. Cocoa, and dark chocolate polyphenols: from biology to clinical applications. Front Immunol. 2017
  4. [CrossRef] 3. Fernández-Murga L, Tarín JJ, García-Perez MA, Cano A. The impact of chocolate on cardiovascular health. Maturitas. 2011
  5. 69(4):312- 321. [CrossRef] 4. Yilmaz MB, Çelik A, Çavusoglu Y, et al. Snapshot evaluation of heart failure in Turkey: baseline characteristics of SELFIE-TR. Turk Kardiyol Dern Ars Turkish Society of Cardiology. 2019
  6. Zuchi C, Tritto I, Carluccio E, Mattei C, Cattadori G, Ambrosio G. Role of endothelial dysfunction in heart failure. Heart Fail Rev. 2020
  7. 25(1):21-30. [CrossRef] 6. Alem MM. Endothelial dysfunction in chronic heart failure: assessment, findings, significance, and potential therapeutic targets. Int J Mol Sci. 2019
  8. 20(13):3198. [CrossRef] 7. Moroni L, Selmi C, Angelini C, Meroni PL. Evaluation of endothelial function by flow-mediated dilation: a comprehensive review in rheumatic disease. Arch Immunol Ther Exp (Warsz). 2017
  9. 65(6):463- 475. [CrossRef] 8. Yoshida T, Kawano H, Miyamoto S, et al. Prognostic value of flow-mediated dilation of the brachial artery in patients with cardiovascular disease. Intern Med. 2006
  10. 45(9):575-579. [CrossRef] 9. Tarro Genta F, Eleuteri E, Temporelli PL, et al. Flow-mediated dilation normalization predicts outcome in chronic heart failure patients. J Card Fail. 2013
  11. 19(4):260-267. [CrossRef] 10. Warriner DR, Lawford P, Sheridan PJ. Measures of endothelial dysfunction predict response to cardiac resynchronisation therapy. Open Heart. 2016
  12. 3(1):e000391. [CrossRef] 11. Schwingshackl L, Christoph M, Hoffmann G. Effects of olive oil on markers of inflammation and endothelial function—A systematic review and meta-analysis. Nutrients. 2015
  13. 7(9):7651-7675. [CrossRef] 12. Changal KH, Khan MS, Bashir R, Sheikh MA. Curcumin preparations can improve flow-mediated dilation and endothelial function: a metaanalysis. Complement Med Res. 2020
  14. 27(4):272-281. [CrossRef] 13. Veronese N, Demurtas J, Celotto S, et al. Is chocolate consumption associated with health outcomes? An umbrella review of systematic reviews and meta-analyses. Clin Nutr. 2019
  15. 38(3):1101-1108. [CrossRef] 14. De Palma R, Sotto I, Wood EG, et al. Cocoa flavanols reduce N-terminal pro-B-type natriuretic peptide in patien