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Journals / Türk Jinekoloji ve Obstetrik Derneği Dergisi / 2010 / Cilt: 7 - Sayı: 2

The value of creatine kinase, estradiol and progesterone levels in early diagnosis of ectopic pregnancies: A prospective controlled study

Ektopik gebeliğin erken tanısında serum kreatin kinaz, östradiol ve progesteronun değeri: Prospektif kontrollu çalışma

Murat KIRAY
Murat ERGİNBAŞ
Ahmet ÇETİN
Feride MİMAROĞLU
Banu DANE
Cem DANE
Pages
133–138
Publication Date
2022-11-05
DOI
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According to AUC levels there was a significant difference between estradiol-creatine kinase levels, progesterone-estradiol levels and progesterone–creatin kinase levels (p values 0.024, 0.0082, and 0.0001, respectively).CONCLUSION: Serum creatine kinase values appear to be a useful marker in the diagnosis of ectopic pregnancy.

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Objective & Hypothesis:INTRODUCTION: To evaluate the role of serum creatine kinase, progesterone and estradiol as a biochemical marker in the early diagnosis of tubal pregnancy.MATERIAL-METHODS: A prospective controlled study was carried out on 44 women with first trimester pregnancy.
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Key Findings & Data:First group (n=22) with tubal pregnancy formed the study group and second group (n=22) with normal intrauterine pregnancy was taken as controls.
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Conclusion & Impact:According to AUC levels there was a significant difference between estradiol-creatine kinase levels, progesterone-estradiol levels and progesterone–creatin kinase levels (p values 0.024, 0.0082, and 0.0001, respectively).CONCLUSION: Serum creatine kinase values appear to be a useful marker in the diagnosis of ectopic pregnancy.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

INTRODUCTION: To evaluate the role of serum creatine kinase, progesterone and estradiol as a biochemical marker in the early diagnosis of tubal pregnancy.MATERIAL-METHODS: A prospective controlled study was carried out on 44 women with first trimester pregnancy. First group (n=22) with tubal pregnancy formed the study group and second group (n=22) with normal intrauterine pregnancy was taken as controls. Serum beta hCG, creatine kinase, progesterone and estradiol levels in the two groups were compared. Surgical treatment had choosen as a treatment modality of ectopic pregnancy.RESULTS: The optimal cutoff value of creatine kinase to be used for the prediction of ectopic pregnancy was 45 IU/l, which resulted in a sensitivity of 86%, specificity of 31%, positive predictive value 55 % and negative predictive value 70 %. The same values for estradiol and progesterone were detected >225 pg/ml, 100 %, 68 %, 75%, 100 % and >13 ng/mL, 95 %, 81 %, % 84, % 97 in discriminating ectopic pregnancies. According to AUC levels there was a significant difference between estradiol-creatine kinase levels, progesterone-estradiol levels and progesterone–creatin kinase levels (p values 0.024, 0.0082, and 0.0001, respectively).CONCLUSION: Serum creatine kinase values appear to be a useful marker in the diagnosis of ectopic pregnancy.

Özet

Amaç: Biyokimyasal belirteç olarak kreatin kinaz, östradiol ve progesteron değerlerinin ektopik gebeliğin erken tanısında değerlerinin araştırılması.Gereç ve Yöntemler: Prospektif kontrollu olarak düzenlenen bu çalışmada laparotomi veya laparoskopi ile tanı konulmuş 22 ektopik gebelik olgusu ve son adet tarihlerine göre 8 hafta ve altında olan 22 normal gebelik olgusu alınmıştır. Kreatin kinaz, östradiol ve progesteron düzeylerinin ektopik gebelik erken tanısında belirleyicilik değerleri karşılaştırılmıştır. Ektopik gebelikler cerrahi olarak tedavi edilmiştir.Bulgular: Ektopik gebeliği belirlemede kreatin kinaz için sınır değer >45 IU/l alınırsa duyarlılık % 86, özgüllük % 31, pozitif belirleyicilik değeri % 55 ve negatif belirleyicilik değeri % 70 olarak bulundu. Östradiol için bu değerler sırasıyla

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Cite This Article

KIRAY, M., ERGİNBAŞ, M., ÇETİN, A., MİMAROĞLU, F., DANE, B., DANE, C. (2022). The value of creatine kinase, estradiol and progesterone levels in early diagnosis of ectopic pregnancies: A prospective controlled study. Türk Jinekoloji ve Obstetrik Derneği Dergisi, Cilt: 7 - Sayı: 2, 133–138. https://ajindex.com/articles/631635

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