Journals / Türk Jinekoloji ve Obstetrik Derneği Dergisi / 2011 / Cilt: 8 - Sayı: 2

Are the criteria of metabolic syndrome associated with pregnancy complications?

Gebelik komplikasyonları metabolik sendrom kriterleriyle ilişkili midir?

Pages
100–106
Publication Date
2022-11-05
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

These cases have high risk for cardiovascular and metabolic diseases in later life.

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: We aimed to compare the components of metabolic syndrome in cases with various pregnancy complications and normal pregnancies.
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Key Findings & Data:Materials and methods: Ninety two cases after 26. gestational week which were followed up in our clinic were included in the study.
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Conclusion & Impact:These cases have high risk for cardiovascular and metabolic diseases in later life.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Aim: We aimed to compare the components of metabolic syndrome in cases with various pregnancy complications and normal pregnancies. Materials and methods: Ninety two cases after 26. gestational week which were followed up in our clinic were included in the study. The rate of the presence of the factors of metabolic syndrome in 40 healthy pregnant women, 21 cases of gestational hypertention, 20 cases of gestational diabetes and 11 cases of preeclampsia were compared. Fasting serum cholesterol, triglyceride, LDL and HDL cholesterol levels were determined.The insulin resistance was calculated with HOMA-IR. Results: Mean levels of BMI were significantly higher in the group of pregnancy complications (GHT 33±5.1, preeclampsia 30.3 ±7.1, GDM 32.1±6.4, and controls 29.2±4.2 kg/m2; P=0.045). Mean leves of fasting serum glucose were also significantly higher in this group (GHT 80.5±16, preeclampsia 94.4±24, GDM 90.3±26, and controls 78.6±10 mg/dL; P=0.023). In the goups with complications mean levels of triglyceride were higher (GHT 267.7±61.5, preeclampsia 290.7±76.6, GDM 221.4± 81.3, and controls 218.3±45mg/dL; P=0.003). Mean levels of HDL did not show any significant difference. The rate of the cases with metabolic syndrome according either to the criteria of WHO (GHT %14.2, Preeclampsia %45.2, GDM %40, and controls %2.5; p=0.001) or NCEP-ATPIII (GHT %38, Preeclampsia %45.4, GDM %40, controls %0; p=0.001) was significantly higher in the groups of complications. Conclusions: We found that the criteria of metabolic syndrome and the rates of cases with MS were significantly higher in the groups of pregnancy complications compared with normal pregnancies. This finding indicates the relationship between both events. These cases have high risk for cardiovascular and metabolic diseases in later life.

Özet

Amaç: Metabolik sendrom kriterlerine sahip olma açısından çeşitli gebelik komplikasyonları bulunan olgular ile normal gebelikler arasında fark olup olmadığını araştırmak amacıyla bu çalışma planlandı. Gereç ve yöntemler: Çalışmaya kliniğimizde takip edilen 26. gebelik haftasının üzerinde 92 gebe dahil edildi. Kırk adet sağlıklı gebeliği olan olgu ile gestasyonel hipertansiyon (21 olgu), gestasyonel diabetik (20 olgu) ve preeklamptik (11 olgu) olguların metabolik sendrom kriterlerine sahip olma oranları karşılaştırıldı. Açlık serum total kolesterol, trigliserid, LDL ve HDL kolesterolü içeren açlık plasma lipid değerleri, açlık glukoz ve insülin değerleri tespit edildi. ‹nsülin direnci için HOMA-IR kullanıldı. Bulgular: Komplike grupta ortalama vücut kitle indeksi anlamlı olarak yüksekti (GHT 33±5.1, preeklampsi 30.3 ±7.1, GDM 32.1±6.4, kontrol grubunda 29.2±4.2 kg/m2; P: 0.045). Bu grupta ortalama açlık glikozu anlamlı olarak yüksekti (GHT 80.5±16, preeklampsi 94.4±24, GDM 90.3±26, kontrol grubunda 78.6±10 mg/dL; P: 0.023). Komplikasyon gruplarında ortalama trigliserid değerleri anlamlı olarak yüksekti (GHT 267.7±61.5, preeklampsi 290.7±76.6, GDM 221.4± 81.3, kontrol grubunda 218.3±45mg/dL; P: 0.003). Ortalama HDL kolesterol değerleri gruplar arasında anlamlı fark göstermemekteydi. Metabolik sendrom tanısı alan olguların oranı hem WHO kriterlerine göre (GHT %14.2, Preeklampsi %45.2, GDM %40, kontrol grubunda %2.5; p=0.001) hem de NCEP-ATPIII kriterlerine göre (GHT %38, Preeklampsi %45.4, GDM %40, kontrol grubunda %0; p=0.001) komplikasyon grubunda anlamlı olarak yüksek bulundu. Sonuç: Gebelik komplikasyonları bulunan grupta metabolik sendrom kriterlerinin ve MS tanısı koyulan olguların oranlarının normal gebelikler ile karşılaştırıldığında daha fazla olduğunu tespit ettik. Bu bulgu her iki durumun arasındaki ilişkiyi göstermektedir. Bu olgular kardiyovasküler ve metabolik hastalıklar açısından ileriki hayatlarında da yüksek risk taşımaktadır.

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Cite This Article

YILDIRIM, Y., ÇETİN, A., DANE, B., USTAOĞLU, F., DÖVENTAŞ, Y., YENİGÜN, M., DANE, C. (2022). Are the criteria of metabolic syndrome associated with pregnancy complications?. Türk Jinekoloji ve Obstetrik Derneği Dergisi, Cilt: 8 - Sayı: 2, 100–106. https://ajindex.com/articles/631590

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