SavedAdd your journal

Journals / Türk Jinekoloji ve Obstetrik Derneği Dergisi / 2012 / Cilt: 9 - Sayı: 1

The role of midtrimester amniotic fluid leptin and endothelin-1 levels in prediction of preeclampsia

Midtrimester amniyotik sıvı leptin ve endotelin-1 düzeylerinin preeklampsi gelişiminin öngörüsündeki rolü

Mehmet TAYYAR
Mustafa TAŞ
Ahmet TAYYAR
Ahter Tanay TAYYAR
Mustafa KULA
Ümmühan ABDÜLREZZAK
Pages
37–41
Publication Date
2022-11-05
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Thus, early follow up and treatment of preeclampsia could decrease possible complications and related financial expense.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: We investigated leptin and endothelin-1 levels of amniotic fluid (AF) which was collected during genetic amniocentesis to use these parameters for prediction of preeclampsia.
📊
Key Findings & Data:Meterial and methods: The level of leptin and endothelin-1 were measured in the samples of AF which were obtained at 16-20 weeks of pregnancy during genetic amniocentesis.
💡
Conclusion & Impact:Thus, early follow up and treatment of preeclampsia could decrease possible complications and related financial expense.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: We investigated leptin and endothelin-1 levels of amniotic fluid (AF) which was collected during genetic amniocentesis to use these parameters for prediction of preeclampsia. Meterial and methods: The level of leptin and endothelin-1 were measured in the samples of AF which were obtained at 16-20 weeks of pregnancy during genetic amniocentesis. We recorded the patients who developed preeclampsia and who had healthy pregnancy and birth. Results: AF leptin and endothelin-1 levels were significantly increased in the preeclamptic group compared to control group. Conclusion: As we detected increased level of AF leptin and endothelin-1 before preeclampsia symptoms develop we think that these proteins can be used to predict preeclampsia. Thus, early follow up and treatment of preeclampsia could decrease possible complications and related financial expense.

Özet

Amaç: Genetik amniyosentez örneklerinde leptin ve endotelin-1 düzeylerini inceleyerek bunların preeklampsi gelişimini tahmin etmede kullanıp kullanılamayacağını araştırmak. Gereç ve yöntemler: Genetik amniyosentezle 16-20 haftalık gebelerden alınan amniyotik sıvı (AS) örneklerinde leptin ve endotelin-1 düzeylerini araştırdık. Prospektif yapılan takiplerde preeklampsi gelişen ve sağlıklı doğum yapan hastaları kaydettik. Bulgular: Preeklampsi gelişen grupta AS leptin ve endotelin-1 düzeyleri kontrol grubundan istatistiksel olarak yüksek bulunmuştur. Yorum: AS'de henüz preeklampsi bulguları ortaya çıkmadan önce leptin ve endotelin-1'in yüksek düzeyde bulunması nedeniyle bu proteinlerin preeklampsiyi önceden tahmin etmede kullanılabileceğini düşünmekteyiz. Böylece preeklampsi takip ve tedavisinin erken başlatılması ile olası komplikasyonların ve bunlara bağlı oluşacak maddi giderlerin azaltılması mümkün olabilecektir.

🔖

Cite This Article

TAYYAR, M., TAŞ, M., TAYYAR, A., TAYYAR, A. T., KULA, M., ABDÜLREZZAK, Ü. (2022). The role of midtrimester amniotic fluid leptin and endothelin-1 levels in prediction of preeclampsia. Türk Jinekoloji ve Obstetrik Derneği Dergisi, Cilt: 9 - Sayı: 1, 37–41. https://ajindex.com/articles/631560

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (13)

  1. Wang C N, Chang SD, Peng HH, Lee YS, Chang YL, et al. Change in amniotic fluid levels of multiple anti-angiogenic proteins before development of preeclampsia and intrauterine growth restriction. J Clin Endocrinol Metab 2010; 95: 14321- 41
  2. Hung TH, Burton GJ. Hypoxia and reoxygenation: a possible mechanism for placental oxidative stress in preeclampsia. Taiwan J Obstet Gynecol 2006; 45: 189- 200
  3. Redman CW, Sargent IL. Placental stres and pre-eclampsia: a revised view. Placenta 2009; 30 (suppl A): S38- S42
  4. Fiore G, Florio P, Micheli L, Nencini C, Rossi M, Cerratini D, et al. Endothelin-1triggers placental oxidative stres pathways: putative role in preeclampsia. J Clin Endocrinol Metab 2005; 90: 4205- 10
  5. Haugen F, Ranheim T, Harsem NK, Lips E, Staff AC, Drevon CA. Increased plasma levels of adipokines in preeclampsia: relationship to placenta and adipose tissue gene expression. Am J Physiol Endocrinol Metab 2006; 290: 326- 33
  6. Grosfeld A, Andre J, Huguel-De MS, Berra E, Pouyssegur J, Guerre-Millo M. Hypoxia-inducible factor1 transactivates the human leptin gene promoter. J Biol Chem 2002; 277: 42953- 7
  7. Madena AB, Fieni S. Amniotic fluid dynamics Acta Biomed 2004; 75 (suppl): 11- 3
  8. Touboul C, Boulvain M, Picone O, Levaillant JM, Frydman R, Senat M. Normal fetal urine production rate estimated with 3-dimensional ultrasonography using the rotational technique (virtual organ computer-aided analysis). Am J Obstet Gynecol 2008; 199: 51- 5
  9. Iurio DR, Marinomi E, Anceschi MM, Eamiliani S, Letizia G, Cosmi EV. Amniotic fluid endothelin-1 levels are increased in pregnancy-inuced hypertension and intrauterino growth retardation. Am J Reprod Imunol 1996; 36: 260- 3
  10. Margarit L, Griffiths A, TsapanosV, Decavalas G, Gumenos D. Second trimester amniotic fluid endothelin concentration. A possible predictor for pre-eclampsia. J Obstet Gynaecol 2005; 25: 18- 20
  11. Chan TF, Su JH, Chung YF, Hsu YH, Yeh YT, Yuan SS. Elevated amniotic fluid leptin levels in prenant women who are destined to develop preeclampsia. Acta Obstet Gynecol Scand 2006; 85: 171- 4
  12. Cagnacci A, Arangino S, Caretto S, Mazza V. Volpe A. Sexual dimorphism in the levels of amniotic fluid leptin in pregnancies at 16 weeks of gestation relation to fetal growth. Eur J Obstet Gynecol Reprod Biol; 2006; 124: 53- 7
  13. Bartha IL, Romero-Carmona R, Escobar-Llompart M, Comino. Delgado R. The relationship between leptin and inflammatory cytokines in women with pre-eclampsia.