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Journals / Türk Jinekoloji ve Obstetrik Derneği Dergisi / 2013 / Cilt: 10 - Sayı: 4

COMPARISON OF MEAN PLATELET VOLUME AND SERUM BILE ACID LEVELS IN INTRAHEPATIC CHOLESTASIS OF PREGNANCY

GEBELİK İNTRAHEPATİK KOLESTAZINDA ORTALAMA TROMBOSİT HACMİ VE SERUM SAFRA ASİTLERİNİN KARŞILAŞTIRILMASI

İlkkan DÜNDER
Herman İŞÇİ
Nilgün GÜDÜCÜ
Başak Özge KAYAN
Alin Başgül YETER
Kılıç AYDINLI
Pages
236–241
Publication Date
2022-11-05
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

But the rate of preterm delivery increased as SBA levels increased.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: The aim of this study was to investigate the relationship between serum bile acid levels (SBA) and mean platelet volume (MPV), a proinflammatory marker and to detect the role of MPV as a marker of fetal well-being in patients with intrahepatic cholestasis of pregnancy (ICP).
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Key Findings & Data:Results: Pregnants with ICP had statistically significantly higher alanine aminotransferase (ALT), aspartate aminotransferase (AST) and fasting SBA levels and the gestational week at delivery was higher in the control group (p 0.05).
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Conclusion & Impact:But the rate of preterm delivery increased as SBA levels increased.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: The aim of this study was to investigate the relationship between serum bile acid levels (SBA) and mean platelet volume (MPV), a proinflammatory marker and to detect the role of MPV as a marker of fetal well-being in patients with intrahepatic cholestasis of pregnancy (ICP). Material and methods: We compared the biochemical parameters of pregnants with ICP and the control group retrospectively. Results: Pregnants with ICP had statistically significantly higher alanine aminotransferase (ALT), aspartate aminotransferase (AST) and fasting SBA levels and the gestational week at delivery was higher in the control group (p 0.05). Mean gestational week at delivery was statistically significantly lower in pregnants with ICP when compared to the control group (37.95 ± 0.92 and 37.25 ± 1.25 weeks, respectively, p < 0.05). Conclusion: There was no relationship between MPV and biochemical parameters used to define ICP. But the rate of preterm delivery increased as SBA levels increased.

Özet

Amaç: Bu çalışmanın amacı, serum safra asitleri (SSA) ile proinşamatuar bir belirteç olan ortalama trombosit hacmi (OTH) arasındaki ilişkiyi ve OTH'nin gebelik intrahepatik kolestazı (GİK) olan hastalarda fetal iyilik halinin belirteci olarak kullanımını tespit etmekti. Gereç ve yöntemler: Bu retrospektif çalışmada GİK'li hastalar ile kontrol grubunu oluşturan gebelerin biokimyasal parametreleri karşılaştırıldı. Bulgular: GİK tanısı alan gebelerin ortalama alanine aminotransferaz (ALT), aspartat aminotransferaz (AST), açlık SSA ölçümleri ve kontrol grubundaki gebelerin doğum sırasındaki gebelik haftaları istatiksel olarak anlamlı düzeyde yüksek saptanmıştır (p 0.05). GİK'li gebeler, kontrol grubundaki gebelerden daha erken haftada doğum yapmıştır (sırasıyla 37.95 ± 0.92 hafta ve 37.25 ± 1.25 hafta, p < 0.05). Sonuç: OTH ile GİK'i tanımlayan biokimyasal parametreler arasında korelasyon tespit edilemedi. Ancak SSA yükseldiğinde erken doğum gözlenme sıklığında artış izlendi.

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Cite This Article

DÜNDER, İ., İŞÇİ, H., GÜDÜCÜ, N., KAYAN, B. Ö., YETER, A. B., AYDINLI, K. (2022). COMPARISON OF MEAN PLATELET VOLUME AND SERUM BILE ACID LEVELS IN INTRAHEPATIC CHOLESTASIS OF PREGNANCY. Türk Jinekoloji ve Obstetrik Derneği Dergisi, Cilt: 10 - Sayı: 4, 236–241. https://ajindex.com/articles/631540

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