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Journals / Türk Jinekoloji ve Obstetrik Derneği Dergisi / 2014 / Cilt: 11 - Sayı: 4

Zayıf over yanıtlı hastalarda uzun GnRH agonist protokol ile GnRH antagonist protokolun karşılaştırılması

Comparison of long GnRH agonist versus GnRH antagonist protocol in poor responders

Mustafa EROĞLU
Belgin DEVRANOĞLU
Sadık ŞAHİN
Tayfun KUTLU
Selçuk SELÇUK
Melda KUYUCU
Pages
203–206
Publication Date
2022-11-05
DOI
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⚡ TL;DR(Too Long; Didn't Read)

Results: Treatment duration and total gonadotropin dosage were significantly higher in women undergoing the long GnRH agonist regimen compared with the GnRH antagonist regimen (p

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: To compare long GnRH agonist with GnRH antagonist protocol in poor responders.
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Key Findings & Data:Materials and Methods: Medical charts of 531 poor responder women undergoing in-vitro fertilization (IVF) cycle at Zeynep Kamil Maternity and Children s Hospital, IVF Center were retrospectively analysed.
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Conclusion & Impact:Results: Treatment duration and total gonadotropin dosage were significantly higher in women undergoing the long GnRH agonist regimen compared with the GnRH antagonist regimen (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: To compare long GnRH agonist with GnRH antagonist protocol in poor responders. Materials and Methods: Medical charts of 531 poor responder women undergoing in-vitro fertilization (IVF) cycle at Zeynep Kamil Maternity and Children s Hospital, IVF Center were retrospectively analysed. Those who received at least 300 IU/daily gonadotropin and had ≤3 oocytes retrieved were enrolled in the study. Poor responders were categorized into two groups as those who received long GnRH agonist or GnRH antagonist regimen. Results: Treatment duration and total gonadotropin dosage were significantly higher in women undergoing the long GnRH agonist regimen compared with the GnRH antagonist regimen (p

Özet

Amaç: Zayıf over yanıtlı hastalarda uzun GnRH agonist protokol ile GnRH antagonist protokolün karşılaştırılması. Gereç ve Yöntemler: Zayıf over yanıtı tanısı ile Zeynep Kamil Kadın ve Çocuk Hastalıkları Hastanesi, Tüp Bebek Ünitesinde in-vitro fertilizasyon (İVF) tedavisi uygulanan 531 hastanın dosyaları retrospektif olarak incelendi. Minimum 300 IU gonadotropinle over stimulasyonu yapılmış ve toplam ≤3 oosit elde edilmiş olan hastalar çalışmaya dahil edildi. Zayıf over yanıtlı hastalar uzun GnRH agonist ve GnRH antagonist protokol ile stimulasyon yapılanlar olmak üzere iki gruba ayrıldı. Bulgular: Tedavi süresi ve toplam kullanılan gonadotropin dozunun GnRH agonist protokolde daha fazla olduğu saptandı. Toplanan ve matür oosit oranları benzer olmakla birlikte iyi kalite embriyo sayısı GnRH antagonist grupta daha fazla idi. Transfer günü ve transfer edilen embriyo sayıları her iki grupta benzerdi. Gebelik (%10,5 vs %14,1), klinik gebelik (%7,7 vs %10,6) ve erken gebelik kaybı oranları (%27,2 vs %35) arasında anlamlı fark gözlenmedi. Sonuç: Zayıf over yanıtlı hastalarda GnRH antagonist protokol tedavi süresi ve maliyetini düşürdüğü için uzun GnRH agonist protokole tercih edilebilir. J Turk Soc Obstet Gynecol 2014;4:203-6

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Cite This Article

EROĞLU, M., DEVRANOĞLU, B., ŞAHİN, S., KUTLU, T., SELÇUK, S., KUYUCU, M. (2022). Zayıf over yanıtlı hastalarda uzun GnRH agonist protokol ile GnRH antagonist protokolun karşılaştırılması. Türk Jinekoloji ve Obstetrik Derneği Dergisi, Cilt: 11 - Sayı: 4, 203–206. https://ajindex.com/articles/631490

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