Journals / Türkiye Fiziksel Tıp ve Rehabilitasyon Dergisi / 2012 / Cilt: 58 - Sayı: 3

Posterior inferior serebellar arterio-venöz malformasyonlu bir olguda yüksek doz kortikosteroid kullanımına bağlı bilateral diz avasküler nekrozu

Bilateral avascular necrosis of the knee due to corticosteroid therapy in a patient with posterior inferior cerebellar anterovenous malformation

Pages
243–245
Publication Date
2022-11-05
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Distal femur and proximal tibia with bilateral involvement is quite rare in the literature.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Osteonecrosis is a common complication of corticosteroid therapy.
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Key Findings & Data:A 27-year-old male patient presented with a history of subarachnoidal hemorrhage due to PICA-AV.
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Conclusion & Impact:Distal femur and proximal tibia with bilateral involvement is quite rare in the literature.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Osteonecrosis is a common complication of corticosteroid therapy. In this study, we report the case of a patient with Posterior Inferior Cerebellar Artery (PICA)-Arteriovenous (AV) malformation who has been diagnosed with knee osteonecrosis involving bilateral proximal tibial and distal femur due to high-dose corticosteroid use. A 27-year-old male patient presented with a history of subarachnoidal hemorrhage due to PICA-AV. He had undergone Gamma knife radiosurgery and received short-term high-dose corticosteroid therapy (dxamethasone 16 mg/kg for 21 days). Two years later, he developed bilateral anterior knee pain of insidious onset. Magnetic resonance imaging performed on admission showed osteonecrosis of the bilateral proximal tibial and distal femur, more pronounced in the tibia. Osteonecrosis is a fairly common complication in patients with the history of corticosteroid use for the treatment of variety of systemic and rheumatic disorders. The condition can manifest itself anywhere in the skeletal system, most commonly in the femoral head. Distal femur and proximal tibia with bilateral involvement is quite rare in the literature.

Özet

Osteonekroz kortikosteroid kullanımına bağlı sık görülen bir komplikasyondur. Literatürde sistemik ve romatizmal hastalıklarda oldukça sık rapor edilmiştir. Biz burada posterior inferior serebellar arterio-venöz malformasyonlu bir olguda yüksek doz kortikosteroid kullanımı sonucu bilateral femur distali ve tibia proksimalinde avasküler nekroz saptanan olguyu sunmayı amaçladık. Literatürde dizde yerleşim yeri olarak femur distali ve tibia proksimalinin birlikte tutulduğu avasküler nekrozlu olgu sayısı oldukça azdır. Olgumuz 27 yaşında erkek hasta, posterior inferior serebellar arterio-venöz malformasyonuna bağlı subaraknoidal hemoraji tablosu gelişmiş. Hastaya beyin cerrahi servisinde GAMA knife ışın tedavisi ve sonrasında 21 gün süre ile 16 mg/kg/gün dozunda deksametazon tedavisi uygulanmış. Tedaviden 2 yıl sonra hastanın her iki diz anterior bölgesinde ağrı yakınması başlamış. Manyetik rezonans görüntülemede bilateral femur distali ve tibia proksimalinde lokalize osteonekroz tespit edildi. Osteonekroz sistemik ve romatizmal hastalığı olan olgularda kortikosteroid kullanımına sekonder olarak gelişen ve sık görülen bir komplikasyondur. Steroid kullanımına bağlı osteonekroz en sık femur başında görülür. Bilateral femur distali ve tibia proksimalinin birlikte tutulumu ise oldukça nadir görülmektedir.

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Cite This Article

YAVUZ, F., YILMAZ, B., ADA, A. M., YAŞAR, E., GÖKTEPE, A. S., GILL, Z. A. (2022). Posterior inferior serebellar arterio-venöz malformasyonlu bir olguda yüksek doz kortikosteroid kullanımına bağlı bilateral diz avasküler nekrozu. Türkiye Fiziksel Tıp ve Rehabilitasyon Dergisi, Cilt: 58 - Sayı: 3, 243–245. https://ajindex.com/articles/628943

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References (13)

  1. Sweet DE, Madewell JE. Pathogenesis of osteonecrosis. In: Resnick D, Niwayama G, eds. Diagnosis of bone and joint disorders. Ed 3. Philadelphia: WB Saunders, 1995:3445-94
  2. Braverman DL, Lachman EA, Nagler W. Avascular Necrosis of Bilateral Knees Secondary to Corticosteroid Enemas. Arch Phys Med Rehabil 1998;79:449-52
  3. Flouzat-Lachaniete CH, Roussignol X, Poignard A, Mukasa MM, Manicom O, Hernigou P. Multifocal Joint Osteonecrosis in Sickle Cell Disease. Open Orthop J 2009;3:32-5
  4. Wong GK, Poon WS, Chiu KH. Steroid-induced a vascular necrosis of the hip in neurosurgical patients: epidemiological study. ANZ J Surg 2005;75:409-10
  5. Yin L, Li YB, WangYS. Dxamethasone-induced adipogenesis in primary marrow stromal cell cultures: mechanism of steroid-induced osteonecrosis. Chin Med J (Engl) 2006;119:581-8
  6. Dovio A, Perazzolo L, Osella G, Ventura M, Termine A, Milano E, et al. Immediate fall of bone formation and transient increase of bone resorption in the course of high-dose, short-term glucocorticoid therapy in young patients with multiple sclerosis. J Clin Endocrinol Metab 2004;89:4923-8
  7. Kameda H, Amano K, Nagasawa H, Ogawa H, Sekiguchi N, Takei H, et al. Notable difference between the development of vertebral fracture and osteonecrosis of the femoral head in patients treated with high-dose glucocorticoids for systemic rheumatic disease. Inter Med 2009;48:1931-8
  8. Calder JD, Buttery L, Revell PA, Pearse M, Polak JM. Apoptosis - a significant cause of bone cell death in osteonecrosis of the femoral head. J Bone Joint Surg Br 2004;86:1209-13
  9. Madsen PV, Andersen G. Multifocal osteonecrosis related to steroid treatment in a patient with ulcerative colitis. Gut 1994;35:132-4
  10. Oinuma K, Harada Y, Nawata Y, Takabayashi K, Abe I, Kamikawa K, et al. Osteonecrosis in patients with systemic lupus erythematosus develops very early after starting high dose corticosteroid treatment. Ann Rheum Dis 2001;60:1145-8
  11. Metselaar HJ, Van Steenberge EJ, Bijnen AB, Jeekel JJ, Van Linge B, Weimar W. Incidence of osteonecrosis after renal transplantation. Acta Orthop Scand 1985;56:413-5
  12. Kabata T, Kubo T, Matsumoto T, Hirata T, Fujioka M, Takahashi KA, et al. Onset of steroid-induced osteonecrosis in rabbits and its relationship to hyperlipaemia and increased free fatty acids. Rheumatology 2005;44:1233-7
  13. Coleman BG, Kressel HY, Dalinka MK, Scheibler ML, Burk DL, Cohen EK. Radiologically negative a vascular necrosis: detection with MR imaging