Acute effects of synthetic cannabinoids on ventricular repolarization parameters

The QT and QTc intervals, Tp-e interval, Tp-e/QT,and Tp-e/QTc ratios were measured from a 12-lead ECG.These parameters were compared between groups andcorrelation analysis was performed.Results: The Tp-e and QTc intervals were significantlyhigher in SC + patients when compared with the SC- group(92.2±10.0, 77.4 ±9.3, p

📌 3 Key Takeaways

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Objective & Hypothesis:An association between ventricular repolarizationparameters (VRPs) and ventricular arrhythmias has beendemonstrated in previous studies.

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Key Findings & Data:The aim of this study was to analyzethe acute effects of SCs on VRPs using electrocardiogram(ECG) measurements of the T-peak to T-end interval (Tp-e),Tp-e/QT ratio, and Tp-e/corrected QT (QTc) ratio.Methods: The present study included 58 patients who wereadmitted to the emergency department who used SCs (SC+) between 2014 and 2016, and 50 healthy control subjects(SC -).

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Conclusion & Impact:The QT and QTc intervals, Tp-e interval, Tp-e/QT,and Tp-e/QTc ratios were measured from a 12-lead ECG.These parameters were compared between groups andcorrelation analysis was performed.Results: The Tp-e and QTc intervals were significantlyhigher in SC + patients when compared with the SC- group(92.2±10.0, 77.4 ±9.3, p

🔬Design:Research Article

📍Scope:2014 Verileri

⚙️Variables:Domain Parameters

Abstract

An association between ventricular repolarizationparameters (VRPs) and ventricular arrhythmias has beendemonstrated in previous studies. However, there are limiteddata related to a relationship between synthetic cannabinoids(SCs) and VRPs. The aim of this study was to analyzethe acute effects of SCs on VRPs using electrocardiogram(ECG) measurements of the T-peak to T-end interval (Tp-e),Tp-e/QT ratio, and Tp-e/corrected QT (QTc) ratio.Methods: The present study included 58 patients who wereadmitted to the emergency department who used SCs (SC+) between 2014 and 2016, and 50 healthy control subjects(SC -). The QT and QTc intervals, Tp-e interval, Tp-e/QT,and Tp-e/QTc ratios were measured from a 12-lead ECG.These parameters were compared between groups andcorrelation analysis was performed.Results: The Tp-e and QTc intervals were significantlyhigher in SC + patients when compared with the SC- group(92.2±10.0, 77.4 ±9.3, p

Özet

Amaç: Önceki çalışmalarda ventriküler aritmi ve ventriküler repolarizasyon parametreleri (VRP) arasındaki ilişki gösterildi. Ancak, VRP ile sentetik kanabinoidler (SK) arasındaki ilişkiyi gösteren sınırlı sayıda veri bulunmaktadır. Bu çalışmada, T-peak to T-end (Tp-e) aralığı, Tp-e/QT ve Tp-e/QTc oranlarının kullanılmasıyla, SK’lerin VRP’ye akut etkilerini analiz edilmesi amaçlandı. Yöntemler: Mevcut çalışma, 2014–2016 yılları arasında, SK kullanmış ve acil servise kabul edilmiş 58 hasta (SK +), ve 50 sağlıklı kontrol olgularını içerdi (SK -). Tp-e aralığı, Tp-e/QT ve Tp-e/QTc oranlarını içeren VRP’ler tüm olgularda 12 derivasyonlu elektrokardiyografiden ölçüldü. Sonra, bu parametreler gruplar arasında karşılaştırıldı ve korelasyon analizi yapıldı. Bulgular: The Tp-e ve QTc aralıkları analamlı olarak, SK - grup ile karşılaştırıldığında SK + grupta daha yüksekti (sırasıyla, 92.2±10.0, 77.4±9.3, p

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Cite This Article

Kılıçkesmez, K. O., Sığırcı, S., Keskin, K., Gürdal, A., Yıldız, S. S., Topçu, H., Sutaşır, M. N. (2022). Acute effects of synthetic cannabinoids on ventricular repolarization parameters. Türk Kardiyoloji Derneği Arşivi, Cilt: 47 - Sayı: 5, 384–390. https://ajindex.com/articles/627258

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