Journals / Türkiye Çocuk Hastalıkları Dergisi / 2014 / Cilt: 8 - Sayı: 1

A Hemolytic Disease due to Minor Blood Group (Anti-C and Anti-E) Incompatibility Leading to Symptomatic Anemia in the Neonatal Period

Yenidoğan Döneminde Anemi ile Semptom Veren Minör Kan rubu (Anti-C ve Anti-E) Uygunsuzluğuna Bağlı Hemolitik Hastalık

Pages
32–34
Publication Date
2022-11-05
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

We present a case with symptoms of severe anemiain the early newborn and even in the fetal period, in whom hemolysis was controlled with intravenous immunoglobulin

📌 3 Key Takeaways

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Objective & Hypothesis:Blood group incompatibility is the most common cause of hemolytic anemia in the early newborn period.
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Key Findings & Data:The widespreaduse of anti-D gammaglobulin in the last four decades has decreased the rate of Rh incompatibility and increased therate of minor blood group incompatibility in the etiology of newborn hemolytic anemia.
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Conclusion & Impact:We present a case with symptoms of severe anemiain the early newborn and even in the fetal period, in whom hemolysis was controlled with intravenous immunoglobulin
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Blood group incompatibility is the most common cause of hemolytic anemia in the early newborn period. The widespreaduse of anti-D gammaglobulin in the last four decades has decreased the rate of Rh incompatibility and increased therate of minor blood group incompatibility in the etiology of newborn hemolytic anemia. It is important to consider minorgroup incompatibility in newborn babies with hemolysis in peripheral blood smears but without major blood groupincompatibility. The clinical picture with minor blood group incompatibility may vary from subclinical hemolysis to activehemolysis and newborn jaundice that necessitates transfusion. We present a case with symptoms of severe anemiain the early newborn and even in the fetal period, in whom hemolysis was controlled with intravenous immunoglobulin

Özet

Erken yenidoğan dönemde hemolitik aneminin en sık nedeni kan grup uyuşmazlıklarıdır. Son dört dekatta anti-Dgamaglobulin kullanmının yaygınlaşması ile Rh uyuşmazlıkları azalmış ve minör kan grubu uyuşmazlıklarının yenidoğanhemolitik anemi etiyolojisindeki oranı giderek artmıştır. Bu nedenle major kan grubu uygunsuzluğu bulunmayan ve periferikyaymada hemoliz bulguları olan yenidoğanlarda minör kan grup uyuşmazlığının düşünülmesi önemlidir. Minör kan grubuuyuşmazlığına bağlı olgularda subklinik hemoliz bulgularından aktif hemoliz ve kan değişimi gerektiren yenidoğan sarılığınakadar değişkenlik gösteren tablolar oluşabilir. Bu yazıda erken yenidoğan hatta fetal dönemde ciddi anemi semptomlarınıgösteren ve intravenöz immünoglobulin ile hemolizi kontrol altına alınan bir olgu sunulmaktadır.

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Cite This Article

GÖKÇE, İ. K., GÜZOĞLU, N., CANPOLAT, F. E., DİLMEN, U., ÇALIŞICI, E., ÖNCEL, M. Y. (2022). A Hemolytic Disease due to Minor Blood Group (Anti-C and Anti-E) Incompatibility Leading to Symptomatic Anemia in the Neonatal Period. Türkiye Çocuk Hastalıkları Dergisi, Cilt: 8 - Sayı: 1, 32–34. https://ajindex.com/articles/627054

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References (1)

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