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Journals / Türkiye Acil Tıp Dergisi / 2008 / Cilt: 8 - Sayı: 3

Evaluating the relationship between serum acetylcholinesterase levels and clinical course and mortality of patients presented with organophosphate and carbamate posinings

Organofosfat ve karbamat içeren insektisid zehirlenmelerinde serum asetilkolinesteraz düzeyleri ile klinik seyir ve mortalite arasındaki ilişkinin değerlendirilmesi

Nil HOCAOĞLU
Şule KALKAN
Sedat YANTURALI
Necip KAHRAMAN
Neşe Çolak ORAY
Aslı UĞURHAN
Pages
121–126
Publication Date
2022-11-05
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

The mean serum AChE level in the patients required mechanical ventilaton was significantly lower according to the patients who did not (1103.90±1718.92 vs 3843.55±3680.44 IU/L, p

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: The aim of this study was to evaluate the relationship between the serum acetylcholinesterase (AChE) levels and the clinical course and mortality of patients presented with organophosphate and carbamate toxicity.
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Key Findings & Data:Materials and Methods: All patients presented to the Emergency Department of Dokuz Eylül University Hospital with organophosphate and carbamate toxicity between 1 June 1993 ile 31 June 2007 were included in this retrospective, cross sectional and analitic study.
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Conclusion & Impact:The mean serum AChE level in the patients required mechanical ventilaton was significantly lower according to the patients who did not (1103.90±1718.92 vs 3843.55±3680.44 IU/L, p
🔬Design:Research Article
📍Scope:2007 Verileri
⚙️Variables:Domain Parameters

Abstract

Objectives: The aim of this study was to evaluate the relationship between the serum acetylcholinesterase (AChE) levels and the clinical course and mortality of patients presented with organophosphate and carbamate toxicity. Materials and Methods: All patients presented to the Emergency Department of Dokuz Eylül University Hospital with organophosphate and carbamate toxicity between 1 June 1993 ile 31 June 2007 were included in this retrospective, cross sectional and analitic study. Demographic characteristics, type of toxic agent, reason for the exposure, clinical signs and findings, serum AChE levels, mechanical ventilation requirements, complications that developed and outcome of the patients were analized. The study data were recorded to a standart study form and a database fort the analysis. Results: A total of 108 patients were included in this study. 13.9% (n=15) of the study patients were children and 86.1% (n=93) were adult. The mean age was 34.1±18.6 and the male/female ratio was 1.57. The mean ‹letiflim (Correspondence) Dr. Sedat YANTURALI Evaluating the relationship between serum acetylcholinesterase levels and clinical course and mortality of patients presented with organophosphate and carbamate posiningsAChE levels of all study patients was 3167±3503 IU/L (min-max: 31- 13685 IU/L). The mean serum AChE level in the patients required mechanical ventilaton was significantly lower according to the patients who did not (1103.90±1718.92 vs 3843.55±3680.44 IU/L, p

Özet

G i r i ş: Bu çalışmada, organofosfat ve karbamatlı insektisidlere maruz kalan hastaların serum asetilkolinesteraz (AChE) düzeyleri ile klinik seyir ve mortaliteleri arasındaki ilişkiyi değerlendirmeyi amaçladık. Gereç ve Yöntem: Geriye dönük, kesitsel ve analitik araştırmamızda, 1993-2007 yılları arasında Dokuz Eylül Üniversitesi Tıp Fakültesi Acil Servisi’ne organofosfat ve karbamatlı insektisid alımıyla başvuran hastaların dosyaları incelenerek, serum AChE düzeyleri ile klinik seyir ve mortaliteleri arasındaki ilişki değerlendirildi. Olguların demografik özellikleri, alınan insektisid tipleri, zehirlenme nedenleri, klinik belirti ve bulguları, serum AChE düzeyleri, mekanik ventilasyon gereksinimleri, gelişen komplikasyonlar ve sonuç verileri değerlendirildi. Tüm veriler çalışma için hazırlanmış standart bilgi formlarına, daha sonra bir veri tabanı programına kaydedildi. Bulgular: Çalışmaya 108 hasta alındı. Bunların 15’i (%13,9) çocuk, 93’ü (%86,1) erişkin ve genel yaş ortalaması 34,1±18,6, erkek/kadın oranı ise 1,57 idi. AChE düzey ortalamaları 3167±3503 IU/L olarak bulundu. (min-maks: 31- 13685 IU/L). Mekanik ventilasyon uygulanan olguların serum AChE düzeyi ortalamaları, mekanik ventilasyon uygulaması na gerek duyulmayan gruba göre istatistiksel olarak anlamlı oranda düşüktü (1103,90±1718.92 vs 3843,55±3680,44 IU/L, p

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Cite This Article

HOCAOĞLU, N., KALKAN, Ş., YANTURALI, S., KAHRAMAN, N., ORAY, N. Ç., UĞURHAN, A. (2022). Evaluating the relationship between serum acetylcholinesterase levels and clinical course and mortality of patients presented with organophosphate and carbamate posinings. Türkiye Acil Tıp Dergisi, Cilt: 8 - Sayı: 3, 121–126. https://ajindex.com/articles/626128

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