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Journals / Balkan Medical Journal / 2016 / Cilt: 33 - Sayı: 6

Correlation between Amitriptyline-Induced Cardiotoxic Effects and Cardiac S100b Protein in Isolated Rat Hearts

Nil HOCAOĞLU
Serap MICILI CİLAKER
Şule KALKAN
Nergis MURAT
Burç AYDIN
Bekir Uğur ERGÜR
Pages
681–687
Publication Date
2022-10-11
DOI
—
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Results: In comparison to control treatment, amitriptyline infusion decreased left ventricular developed pressure (LVDP), dp/dtmax and heart rate (HR) and significantly prolonged QRS duration (p

📌 3 Key Takeaways

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Objective & Hypothesis:Background: Amitriptyline is an important cause of mortality due to its cardiovascular toxicity.
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Key Findings & Data:Aims: To investigate the changes in levels of cardiac S100b protein on amitriptyline-induced cardiotoxicity and also to examine the correlation between amitriptyline-induced cardiotoxic effects and cardiac S100b protein in an isolated rat heart model.
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Conclusion & Impact:Results: In comparison to control treatment, amitriptyline infusion decreased left ventricular developed pressure (LVDP), dp/dtmax and heart rate (HR) and significantly prolonged QRS duration (p
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Background: Amitriptyline is an important cause of mortality due to its cardiovascular toxicity. Aims: To investigate the changes in levels of cardiac S100b protein on amitriptyline-induced cardiotoxicity and also to examine the correlation between amitriptyline-induced cardiotoxic effects and cardiac S100b protein in an isolated rat heart model. Study Design: Animal experimentation, isolated heart model. Methods: After a stabilization period, isolated hearts were randomized to two groups (n=5 and n=7). In the control group, isolated hearts were subjected to an infusion of 5% dextrose for 60 minutes. In the amitriptyline group, 5.5×10-5 M amitriptyline was infused for 60 minutes to achieve amitriptyline toxicity. After the infusion period, heart tissues were removed for histological examination. Results: In comparison to control treatment, amitriptyline infusion decreased left ventricular developed pressure (LVDP), dp/dtmax and heart rate (HR) and significantly prolonged QRS duration (p

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Cite This Article

HOCAOĞLU, N., CİLAKER, S. M., KALKAN, Ş., MURAT, N., AYDIN, B., ERGÜR, B. U. (2022). Correlation between Amitriptyline-Induced Cardiotoxic Effects and Cardiac S100b Protein in Isolated Rat Hearts. Balkan Medical Journal, Cilt: 33 - Sayı: 6, 681–687. https://ajindex.com/articles/461342

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