Journals / Türkiye Acil Tıp Dergisi / 2008 / Cilt: 8 - Sayı: 1

Mad honey poisoning from the past to the present

Geçmişten günümüze deli bal zehirlenmesi

Pages
46–49
Publication Date
2022-11-05
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In the present review, the historical progress, clinical presentation and treatment modalities of grayanotoxin poisoning were analyzed in the light of the literature.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Grayanotoxin which has toxic effects on Na channels is a natural product derived from the plants belongs to Ericaceae family.
📊
Key Findings & Data:Although the “grayonotoxin (mad honey)” poisoning is not known commonly, there are some clinical and experimental studies, case series and case reports in the medical literature about it.
💡
Conclusion & Impact:In the present review, the historical progress, clinical presentation and treatment modalities of grayanotoxin poisoning were analyzed in the light of the literature.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Grayanotoxin which has toxic effects on Na channels is a natural product derived from the plants belongs to Ericaceae family. Although the “grayonotoxin (mad honey)” poisoning is not known commonly, there are some clinical and experimental studies, case series and case reports in the medical literature about it. Grayanotoxin poisoning can cause symptoms and findings such as bradycardia, hypotension and syncope. In addition, mortal cardiac rhythms such as complete atrioventricular block and asystole have also been reported. Appropriate fluid replacement and atropine should generally be sufficient for the treatment. In the present review, the historical progress, clinical presentation and treatment modalities of grayanotoxin poisoning were analyzed in the light of the literature.

Özet

Grayanotoksin, Na kanalları üzerinde toksik etki gösteren, Ericaceae familyası bitkilerinin çiçek nektarı ve polenlerinden üretilen ballarda bulunan doğal bir üründür. Grayanotoksin/deli bal zehirlenmesi az bilinmesine rağmen, tıbbi literatürde bu konu ile ilgili yapılmış klinik çalışma, laboratuvar çalışması, olgu sunumları ve olgu serileri bulunmaktadı r. Grayanotoksin zehirlenmesi, bradikardi, hipotansiyon ve senkop gibi semptom ve bulgulara neden olabilir. Ayrıca grayanotoksin intoksikasyonu tanısı koyulan hastalarda, atrioventriküler tam blok ve asistoli gibi ölümcül kardiyak ritimler de bildirilmiştir. Uygun sıvı replasmanı ve atropin tedavi için genellikle yeterlidir. Bu yazıda, deli bal zehirlenmesinin tarihsel seyri, klinik sunumu ve tedavi yöntemleri literatür ışığında incelendi.

🔖

Cite This Article

TÜREDİ, S., GÜNDÜZ, A., TATLI, Ö. (2022). Mad honey poisoning from the past to the present. Türkiye Acil Tıp Dergisi, Cilt: 8 - Sayı: 1, 46–49. https://ajindex.com/articles/626126

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (18)

  1. Leach DG. Ancient curse of the rhododendron. Am Horticulturist 1972;51:20-29
  2. Xenophon: Anabasis, or March Up Country. Fordham University web site. Available at: http:// www. fordham. edu/ halsall/ ancient/ xenophon- anabasis. html#BOOK%20II. Eriflim tarihi: 12 Aral›k 2007
  3. Kebler LF. Poisonous honey. Am Pharm Assoc Proc 1896;44:167-74
  4. Vickers A, Zollman C. ABC of complementary medicine: herbal medicine. BMJ 1999;319(7216):1050-3
  5. Lampe KF. Rhododendrons, mountain laurel, and mad honey. JAMA 1988;259:2009
  6. Stevens PF. Rhododendron L. In: Davis PF, editor. Flora of Turkey and the East Aegean Islands. Edinburgh: Edinburgh University Press; 1978. p. 90-4
  7. Gunduz A, Bostan H, Turedi S, Nuho¤lu I, Patan T. Wild flowers and mad honey. Wilderness Environ Med 2007;18:69-71
  8. Terai T, Osakabe K, Katai M, Sakaguchi K, Narama I, Matsuura T, et al. Preparation of 9-hydroxy grayanotoxin derivatives and their acute toxicity in mice. Chem Pharm Bull (Tokyo) 2003;51:351-3
  9. Maejima H, Kinoshita E, Seyama I, Yamaoka K. Distinct sites regulating grayanotoxin binding and unbinding to D4S6 of Na(v)1.4 sodium channel as revealed by improved estimation of toxin sensitivity. J Biol Chem 2003;278:9464-71
  10. Onat F, Yegen BC, Lawrence R, Oktay A, Oktay S. Site of action of grayanotoxins in mad honey in rats. J Appl Toxicol 1991;11:199-201
  11. Onat FY, Yegen BC, Lawrence R, Oktay A, Oktay S. Mad honey poisoning in man and rat. Rev Environ Health 1991;9:3-9
  12. Ascioglu M, Ozsemi C, Dogan P, Ozturk F. Effects of Acute grayanotoxin-1 administration on hepatic and renal functions in rats. Turk J Med Sci 2000;30:23-27
  13. Oztasan N, Altinkaynak K, Akcay F, Gocer F, Dane S. Effects of mad honey on blood glucose and lipid levels in rats with streptozocin-induced diabetes. Turk J Vet Anim Sci 2005;29:1093-6
  14. Yavuz H, Ozel A, Akkus I, Erkul I. Honey poisoning in Turkey. Lancet 1991;337:789-90
  15. Yilmaz O, Eser M, Sahiner A, Altintop L, Yesildag O. Hypotension, bradycardia and syncope caused by honey poisoning. Resuscitation 2006;68:405-8. 16. von Malottki K, Wiechmann HW. Acute life-threatening bradycardia: food poisoning by Turkish wild honey. [Article in German] Dtsch Med Wochenschr 1996;121:936-8
  16. Biberoğlu S, Biberoğlu K, Komsuoğlu B. Mad honey. JAMA 1988;259:1943
  17. Sütlüpinar N, Mat A, Satgano¤lu Y. Poisoning by toxic honey in Turkey. Arch Toxicol 1993;67:148-50
  18. Gössinger H, Hruby K, Pohl A, Davogg S, Sutterlütti G, Mathis G. Poisoning