Journals / Türk Hijyen ve Deneysel Biyoloji Dergisi / 2016 / Cilt: 73 - Sayı: 4

Investigation of the hair and urine samples’ utility for screening lead poisoning

Kurşun maruziyetinin taranmasında saç ve idrar numunelerinin kullanılabilirliğinin araştırılması

Pages
303–310
Publication Date
2022-11-05
DOI
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⚡ TL;DR(Too Long; Didn't Read)

People were evaluated according to two different whole blood exposure levels (10 μg/dL and 30 μg/dL).Results: 24 hour urine and hair lead levels of the groups classified according to whole blood exposure limits were different from each other and statistically significant (p

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Objective & Hypothesis:Objective: The aim of this study is to compare whole blood, 24 hour urine and hair lead levels which were measured concurrently, and evaluate the utility of hair and urine samples for screening of lead exposure.Methods: The data of 436 workers who referred to Ankara Occupational Diseases Hospital between 2010 and 2014 for periodic examination were evaluated.
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Key Findings & Data:People who examined whole blood, 24 hour urine and hair lead levels concurrently were included in this study.
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Conclusion & Impact:People were evaluated according to two different whole blood exposure levels (10 μg/dL and 30 μg/dL).Results: 24 hour urine and hair lead levels of the groups classified according to whole blood exposure limits were different from each other and statistically significant (p
🔬Design:Research Article
📍Scope:2010 Verileri
⚙️Variables:Domain Parameters

Abstract

Objective: The aim of this study is to compare whole blood, 24 hour urine and hair lead levels which were measured concurrently, and evaluate the utility of hair and urine samples for screening of lead exposure.Methods: The data of 436 workers who referred to Ankara Occupational Diseases Hospital between 2010 and 2014 for periodic examination were evaluated. People who examined whole blood, 24 hour urine and hair lead levels concurrently were included in this study. People were evaluated according to two different whole blood exposure levels (10 μg/dL and 30 μg/dL).Results: 24 hour urine and hair lead levels of the groups classified according to whole blood exposure limits were different from each other and statistically significant (p

Özet

Amaç: Bu çalışmanın amacı, eş zamanlı olarak bakılan tam kan, 24 saatlik idrar ve saç kurşun düzeylerinin birbiri ile karşılaştırılması ve kurşun maruziyetinin taranmasında saç ve idrar numunelerinin kullanılabilirliğinin araştırılmasıdır.Yöntemler: Ankara Meslek Hastalıkları yılları Hastanesi'ne periyodik muayene amacıyla başvuran 436 işçiye ait veriler değerlendirildi. Tam kan, 24 saatlik idrar ve saç kurşun düzeyleri eş zamanlı olarak bakılmış kişiler çalışmaya dâhil edildi. Kişiler iki farklı tam kan maruziyet düzeyine (10 ?g/dL ve 30 ?g/dL) göre değerlendirildi.Bulgular: Tam kan maruziyet sınırlarına göre sınıflandırılan grupların 24 saatlik idrar ve saç kurşun düzeyi birbirinden farklı ve istatistiksel olarak anlamlı idi (p

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Cite This Article

ERCAN, M., YILMAZ, F. M., TORUN-GÜNGÖR, O., TUTKUN, E., BÜYÜKŞEKERCI, M., BAL, C. (2022). Investigation of the hair and urine samples’ utility for screening lead poisoning. Türk Hijyen ve Deneysel Biyoloji Dergisi, Cilt: 73 - Sayı: 4, 303–310. https://ajindex.com/articles/625038

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References (15)

  1. Xu J, Lian LJ, Wu C, Wang XF, Fu WY, Xu LH. Lead induces oxidative stress, DNA damage and alteration of p53, Bax and Bcl-2 expressions in mice. Food Chem Toxicol, 2008;46(1):1488-94
  2. Malekirad AA, Oryan S, Fani A, Babapor V, Hashemi M, Baeeri M, et al. Study on clinical and biochemical toxicity biomarkers in a zinc-lead mine workers. Toxicol Ind Health, 2010;26(6):331-7
  3. Agency for Toxic Substance and Disease Registry (ATSDR). Toxicological profile for lead-update. Atlanta: U.S. Department of Health & Human Services, Public Health Service, 2007
  4. Bressler J, Kim KA, Chakraborti T, Goldstein G. Molecular mechanisms of lead neurotoxicity. Neurochem Res, 1999;24(4):595-600
  5. Bradbury MW, Deane R. Permeability of the blood brain barrier to lead. Neurotoxicology, 1993;14(2- 3):131-6
  6. Bressler JP, Goldstein GW. Mechanisms of lead neurotoxicity. Biochem Pharmacol, 1991;41(4):479- 84
  7. Patrick Lyn. Lead toxicity part II: the role of free radical damage and the use of antioxidants in the pathology and treatment of lead toxicity. Alternative Med Rev, 2006;11(2):114
  8. Wedeen RP, Mallik DK, Batuman V. Detection and treatment of occupational lead nephropathy. Arch Intern Med, 1979;139(1):53–57
  9. Lidsky TI, Schneider JS. Lead neurotoxicity in children: basic mechanisms and clinical correlates. Brain, 2003;126(1): 5–19
  10. Garza A, Vega R, Soto E. Cellular mechanisms of lead neurotoxicity. Med Sci Monit, 2006;12(3): RA57–65
  11. R.R. Lauwerys and P. Hoet. Biological monitoring of exposure to inorganic and organometallic substances. In: R.R. Lauwerys, P. Hoet, eds. Industrial Chemical Exposure: Guidelines for Biological Monitoring. Florida. Lewis Publishers, 2001:21-280
  12. Fischbein A. Occupational and environmental exposure to lead. In: W.M.Rom, ed. Environmental and Occupational Medicine. Philadelphia. LippincottRaven Publisher, 1998;973-996
  13. Barbosa F Jr1, Tanus-Santos JE, Gerlach RF, Parsons PJ. A critical review of biomarkers used for monitoring human exposure to lead: advantages, limitations, and future needs. Environ health perspect, 2005;113(12):1669-74. 14. http://www.mayomedicallaboratories.com/ testcatalog/Clinical+and+Interpretive/8495 (erişim tarihi: 07.01.2017
  14. Hopfer M.S. General clinical tests, heavy metals. In: Alan H. B. Wu, ed. Tietz Clinical Guide to Laboratory Tests. California. WB Saunders Company, 2005;658
  15. American Conference of Governmental Industrial Hygienists. Threshold Limit Values for Chemical Substancesan