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Journals / Türk Hematoloji Onkoloji Dergisi / 1998 / Cilt: 8 - Sayı: 3

Assessment of the acute lymphoblastic leukemia cases with L-Asparaginase allergy

L-Asparaginaz allerjisi olan akut lenfoblastik lösemili olguların değerlendirilmesi

Ertan KAYSERİLİ
Pamir GÜLEZ
Füsun ATLIHAN
Gülşen AKTAŞ
Canan VERGİN
Pages
161–164
Publication Date
2022-11-05
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

As a conclusion, when slight allergic reactions develop during L- asparaginase treatment in ALL, it is pos-sible to complete the therapy with the addition of antiallergic drugs.

📌 3 Key Takeaways

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Objective & Hypothesis:All the anticancer drugs commonly used in the treatment of ALL have adverse effects.
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Key Findings & Data:Allergy against L- asparaginase has been detected in 13 cases (%8.02) of 161 cases diagnosed as ALL and treated at Dr.
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Conclusion & Impact:As a conclusion, when slight allergic reactions develop during L- asparaginase treatment in ALL, it is pos-sible to complete the therapy with the addition of antiallergic drugs.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

All the anticancer drugs commonly used in the treatment of ALL have adverse effects. Allergy is the most important adverse effect of one of these drugs, L-asparaginase. Allergy against L- asparaginase has been detected in 13 cases (%8.02) of 161 cases diagnosed as ALL and treated at Dr. Behçet Uz Children's Hospital. These adverse effects were seen in 6 cases (%3.7) during the induction therapy and in 7 cases (%4.32) at the further phases of therapy. L-asparaginase therapy was discontinued in 6 patients (%3.7) in whom anaphylaxis developed. In 7 patients (%4.32) only urticaria was seen, antihistaminics and dexametasone were used and the therapy was completed. In these cases allergic reactions did not recur. As a conclusion, when slight allergic reactions develop during L- asparaginase treatment in ALL, it is pos-sible to complete the therapy with the addition of antiallergic drugs.

Özet

Akut lenfoblastik lösemi(ALL) tedavisinde kullanılan kemoterapötiklerin tümünün kendine özgü yan etkileri vardır. Bu kemoterapötik ajanlardan birisi olan L-asparaginazın en önemli yan etkisi allerjik reaksiyonlardır. Dr. Behçet Uz Çocuk Hastanesinde tedavi edilen 161 ALL'li olgunun 13'ünde (%8.02) L-asparaginaz allerjisi saptanmıştır. Bu yan etkiler olguların 6'sında (%3- 7) indüksiyon tedavisi sırasında, 7'sinde (%4.32) ise tedavinin daha sonraki evrelerinde görülmüştür. Anaflaksi saptanan 6 olguda (%3.7) L-asparaginaz tedavisi kesilmiştir. Sadece ürtiker gelişen 7 olguda (%4.32) tedaviden önce antihistaminik ve deksametazon uygulanarak kürler tamamlanmış ve bu olgularda allerjik reak-siyonlar bir daha tekrarlamamıştır. Sonuç olarak L-asparaginaz tedavisi uygulanan ALL'li hastalarda hafif allerjik reaksiyonlar görüldüğünde antiallerjik tedavi ile kürlerin tamamlanmasının mümkün olduğu düşünülmüştür.

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Cite This Article

KAYSERİLİ, E., GÜLEZ, P., ATLIHAN, F., AKTAŞ, G., VERGİN, C. (2022). Assessment of the acute lymphoblastic leukemia cases with L-Asparaginase allergy. Türk Hematoloji Onkoloji Dergisi, Cilt: 8 - Sayı: 3, 161–164. https://ajindex.com/articles/624871

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