Journals / Türk Göğüs Kalp Damar Cerrahisi Dergisi / 2011 / Cilt: 19 - Sayı: 4

Prognostic importance of plasma levels of brain natriuretic peptide in congenital cardiac surgery

Doğuştan kalp cerrahisinde beyin natriüretik peptid plazma düzeyinin prognostik önemi

Pages
507–512
Publication Date
2022-11-05
DOI
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Conclusion: In conclusion, there was no statistically significant differenece between the groups in terms of pre- and postoperative NT-proBNP levels.

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Objective & Hypothesis:Background: In this study we investigated the prognostic importance of the relationship of the role of pre- and postoperative N terminal-pro brain natriuretic peptide (NT-proBNP) levels in the early diagnosis and monitoring of postoperative deficiency with morbidity and mortality in patients operated on under extracorporeal circulation support for congenital cardiac surgery.
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Key Findings & Data:Methods: The pre- and postoperative echocardiographic data, the pre- and postoperative 2- and 24-hour NT-proBNP levels along with the hemodynamic and laboratory values of 20 consecutive patients were evaluated.
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Conclusion & Impact:Conclusion: In conclusion, there was no statistically significant differenece between the groups in terms of pre- and postoperative NT-proBNP levels.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Background: In this study we investigated the prognostic importance of the relationship of the role of pre- and postoperative N terminal-pro brain natriuretic peptide (NT-proBNP) levels in the early diagnosis and monitoring of postoperative deficiency with morbidity and mortality in patients operated on under extracorporeal circulation support for congenital cardiac surgery. Methods: The pre- and postoperative echocardiographic data, the pre- and postoperative 2- and 24-hour NT-proBNP levels along with the hemodynamic and laboratory values of 20 consecutive patients were evaluated. Patients were divided into two groups, with those being under volume load in group 1 and those being under pressure load in group 2. Results: The pre- and postoperative NT-proBNP levels followed a parallel course in both groups. The postoperative NT-proBNP levels were found to be higher when compared to the preoperative NT-proBNP levels in both groups. It has been observed that the NT-proBNP level gives an idea about cardiac functions when intra-group and general evaluations are considered. No significant difference could be found between the groups regarding the preoperative and postoperative NT-proBNP plasma levels. Conclusion: In conclusion, there was no statistically significant differenece between the groups in terms of pre- and postoperative NT-proBNP levels. We advocate that the NT-proBNP levels in patients with congenital hearth disease is an important diagnostic tool in the early evaluation of pre- and poetoperative cardiac failure. In addition, it is also important test to commence proactive treatment of cardiac failure.

Özet

Amaç: Çalışmada doğuştan kalp cerrahisinde vücut dışı dolaşım desteği ile ameliyat edilen hastaların ameliyat öncesi ve sonrası N terminal-öncü beyin natriuretik peptid (NT-proBNP) düzeylerinin, ameliyat sonrası yetmezliğin erken tanısı ve takibindeki rolü ile morbidite ve mortalite arasındaki ilişkinin prognostik önemi araştırıldı. Çalışma planı: Ardışık 20 hastanın ameliyat öncesi ve sonrası ekokardiyografik bilgileri, ameliyat öncesi ve sonrası 2. ile 24. saatlerdeki NT-proBNP düzeyleri, hemodinamik ve laboratuvar sonuçları değerlendirildi. Hastalar, volüm yükü altındakiler grup 1 ve basınç yükü altındakiler grup 2 olarak iki gruba ayrıldı. Bulgular: İki grup arasında ameliyat öncesi ve sonrası NT-proBNP düzeyleri paralel seyir izledi. Her iki grupta da ameliyat sonrası NT-proBNP düzeyleri, ameliyat öncesi NT-proBNP düzeylerine göre daha yüksek bulundu. Grup içi ve genel değerlendirmeler ele alındığında NT-proBNP seviyesinin kardiyak fonksiyonlar hakkında fikir verdiği görülmektedir. Gruplar arasında ameliyat öncesi ve ameliyat sonrası plazma NT-proBNP düzeyleri arasında anlamlı fark bulunamadı. Sonuç: Sonuç olarak, ameliyat öncesi ve ameliyat sonrası N-proBNP seviyelerinde gruplar arasında istatistiksel olarak anlamlı bir fark bulunamamıştır. Doğuştan kalp hastalığı bulunan hastalarda NT-proBNP seviyelerinin ameliyat öncesi ve sonrası kalp yetmezliğinin erken değerlendirilmesinde önemli bir tanı aracı olduğunu savunuyoruz. İlave olarak, NT-proBNP kalp yetmezliğinin proaktif tedavisinin başlanmasında da önemli bir testtir.

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Cite This Article

SIĞNAK, I. Ş., YANAR, M., HELVACI, H. (2022). Prognostic importance of plasma levels of brain natriuretic peptide in congenital cardiac surgery. Türk Göğüs Kalp Damar Cerrahisi Dergisi, Cilt: 19 - Sayı: 4, 507–512. https://ajindex.com/articles/624658

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