Journals / Respiratory Case Reports / 2017 / Cilt: 6 - Sayı: 2

Gecikmiş Tanılı Paraquat İntoksikasyonunda Ekstrakorporeal Membran Oksijenasyonu Sırasında Dirençli Hipoksemi

Persistent Hypoxemia during Extracorporeal Membrane Oxygenation in Delayed Diagnosed Paraquat Intoxication

Pages
118–123
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The aim of this study was to examine probable causes of persistent hypoxemia during V-V ECMO observed in this case.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Paraquat is a highly toxic herbicide used in agriculture worldwide that causes progressive pulmonary fibrosis (PF) due to selective accumulation in the lungs.
📊
Key Findings & Data:Veno-venous extracorporeal membrane oxygenation (V-V ECMO) is currently a widely used therapeutic strategy for acute respiratory distress syndrome (ARDS).
💡
Conclusion & Impact:The aim of this study was to examine probable causes of persistent hypoxemia during V-V ECMO observed in this case.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Paraquat is a highly toxic herbicide used in agriculture worldwide that causes progressive pulmonary fibrosis (PF) due to selective accumulation in the lungs. Paraquat intoxication can result in death due to multi-organ failure within a few days or respiratory failure due to PF within a few weeks. Veno-venous extracorporeal membrane oxygenation (V-V ECMO) is currently a widely used therapeutic strategy for acute respiratory distress syndrome (ARDS). Presently described is case of a 46-year-old man who was hospitalized with ARDS and treated with V-V ECMO. Expected oxygenation levels could not be attained despite ECMO support. When excluding causes for hypoxia in this patient on ECMO, detailed medical history revealed exposure to paraquat 3 weeks previously. Severe hypoxemia persisted during V-V ECMO and the patient died on sixth day after admission. The aim of this study was to examine probable causes of persistent hypoxemia during V-V ECMO observed in this case.

Özet

Paraquat, tarımda yaygın kullanılan ve akciğerlerde birikimi sonucu ilerleyici pulmoner fibrozise neden olan toksik özelliği yüksek bir herbisiddir. Paraquat intoksikasyonunda birkaç gün içinde çoklu organ yetmezliği veya birkaç hafta içinde pulmoner fibrozise bağlı solunum yetmezliği sonucu ölüm gelişebilir. Veno-venöz ekstrakorporeal membran oksijenasyonu (V-V ECMO) günümüzde akut solunum sıkıntısı sendromunda (ARDS) yaygın olarak uygulanan bir tedavi stratejisidir. Bu yazıda ARDS tanısı ile yatırılan ve tedavi sürecinde V-V ECMO kullanılan bir olguyu sunduk. ECMO desteğine rağmen yeterli oksijenasyona ulaşılamayan ve ECMO'ya bağlı hipoksi nedenleri dışlanan olguda, tekrar sorgulanan tıbbi öyküsü sonucu üç hafta önce paraquat maruziyeti olduğu saptandı. V-V ECMO desteğine rağmen hipoksi devam eden olgu, yoğun bakıma yatışının 6. günü kaybedildi. Bu olgu aracılığı ile V-V ECMO sırasında dirençli hipoksinin nedenlerini gözden geçirmeyi amaçladık.

🔖

Cite This Article

GİRGİN, N. K., ÜNLÜ, N., ŞENKAYA, I. S., İŞÇİMEN, R., KAHVECİ, F., ÇAĞLAYAN, H. (2017). Gecikmiş Tanılı Paraquat İntoksikasyonunda Ekstrakorporeal Membran Oksijenasyonu Sırasında Dirençli Hipoksemi. Respiratory Case Reports, Cilt: 6 - Sayı: 2, 118–123. https://ajindex.com/articles/302481

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (1)

  1. Liu XW, Ma T, Qu B, Ji Y, Liu Z. Prognostic value of initial arterial lactate level and lactate metabolic clearance rate in patients with acute paraquat poisoning. Am J Emerg Med 2013; 31:1230-5. [CrossRef] 2. Bertram A, Haenel SS, Hadem J, Hoeper MM, Gottlieb J, Warnecke G, et al. Tissue concentration of paraquat on day 32 after intoxication and failed bridge to transplantation by extracorporeal membrane oxygenation therapy. BMC Pharmacol Toxicol 2013; 6:14:45. [CrossRef] 3. Chiumello D, Brioni M. Severe hypoxemia: which strategy to choose. Crit Care 2016; 20:132. [CrossRef] 4. Combes A, Bréchot N, Luyt CE, Schmidt M. Extracorporeal membrane oxygenation: beyond rescue therapy for acute respiratory distress syndrome? Curr Opin Crit Care 2017; 23:60-5. [CrossRef] 5. Nunes LB, Mendes PV, Hirota AS, Barbosa EV, Maciel AT, Schettino GP, et al; ECMO Group. Severe hypoxemia during veno-venous extracorporeal membrane oxygenation: exploring the limits of extracorporeal respiratory support. Clinics (Sao Paulo) 2014; 69:173-8. [CrossRef] 6. Gawarammana IB, Buckley NA. Medical management of paraquat ingestion. Br J Clin Pharmacol 2011; 72:745- 57. [CrossRef] 7. Zhang Q, Wu WZ, Lu YQ, Wang JZ, Shang AD, Yao F, Chen Y. Successful treatment of patients with paraquat intoxication: three case reports and review of the literature. J Zhejiang Univ Sci B 2012; 13:413-8. [CrossRef] 8. Asl AS, Dadashzadeh P. Acute kidney injury in patients with paraquat intoxication; a case report and review of the literature. J Renal Inj Prev 2016; 5:203-6. [CrossRef] 9. Schmidt M, Tachon G, Devilliers C, Muller G, Hekimian G, Bréchot N, et al. Blood oxygenation and decarboxylation determinants during venovenous ECMO for respiratory failure in adults. Intensive Care Med 2013; 39:838- 46. [CrossRef] 10. Agerstrand CL, Bacchetta MD, Brodie D. ECMO for adult respiratory failure: current use an evolving application. ASAIO J 2014; 60:255-62. [CrossRef] 11. Walder B, Bründler MA, Spiliopoulos A, Romand JA. Successful single-lung transplantation after paraquat intoxication. Transplantation 1997; 64:789-91. [CrossRef