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Journals / Türk Fertilite Dergisi / 2002 / Cilt: 10 - Sayı: 1

The results of intrauterin insemination in primary infertile couples inducted with 501U recombinant FSH versus 100 MG clomiphene citrate

Primer infertil çiftlerde uygulanan intrauterin inseminasyonda rekombinant FSH ile klomifen sitrat sonuçlarının karşılaştırılması

Hüseyin GÖRKEMLİ
Cemalettin AKYÜREK
Dilek AK
Murat AKTAN
Selçuk DUMAN
Pages
48–52
Publication Date
2022-11-05
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

When the cost of treatment is considered, trial of cc-IUI can be preferred at least for 2 cycles in selected patients.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: The aim of this study was to compare the pregnancy outcome ofciomiphene citrate (cc) versus low dose recombinant FSH (rFSH) in İntrauterin insemination cycles.
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Key Findings & Data:Materials And Methods: Ovulation induction was done with cc (31 cycles) or rFSH (51 cycles) to 55 infertile women.CC was started at fifth day of cycle and continued for five days 100 rng daily.
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Conclusion & Impact:When the cost of treatment is considered, trial of cc-IUI can be preferred at least for 2 cycles in selected patients.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: The aim of this study was to compare the pregnancy outcome ofciomiphene citrate (cc) versus low dose recombinant FSH (rFSH) in İntrauterin insemination cycles. Institution: The Assiste Reproductive Technology Unit of Selçuk University Meram Medical Faculty, Konya. Materials And Methods: Ovulation induction was done with cc (31 cycles) or rFSH (51 cycles) to 55 infertile women.CC was started at fifth day of cycle and continued for five days 100 rng daily. Recombinant FSH was started in the second or third day of cycle and continued until the leading follicle reached 18 mm. in diameter. Results: The pregnancy rate per patient was 57.1 % (12/21) in cc and 52.9 % (18/34) in rFSH cycles. This result was not statistically significant. The pregnancy rate per cycle was 38.7 % (12/31) in cc and 35.2 % (18/51) in rFSH cycles. This result was also not statistically significant. Conclusion: As long as the convenient couples are selected, cc-IUI is as successful as rFSH-IUI procedure in the treatment of infertility. When the cost of treatment is considered, trial of cc-IUI can be preferred at least for 2 cycles in selected patients.

Özet

Amaç: İntrauterin inseminasyon slkluslarında Klomifen sürat (KS) ve düşük doz rekombinant FSH (rFSH)'in gebelik başarısinı karşılaştırmak. Yer: Selçuk Üniversitesi Tıp Fakültesi Yardımcı Üreme Teknikleri Ünitesi Materyal ve Metod: Toplam 55 kadına en fazla 2 siklus olmak üzere ya KS (31 siklus) ya da r FSH (51 siklus) ile ovulasyon indüksiyonu yapıldı. KS siklusun 5. günü başlandı ve 100 mg 5 gün kullanıldı, r FSH 501 Ü/gün dozunda siklusun 2. veya 3. günü başlandı ve en az 18 mın'lik öncü birfollikül elde edilene kadar devam edildi. Bulgular: Hasta başına düşen gebelik oranı KS-IUI sikluslarinda %57.l (12/21), rFSH-IUI sikluslarinda %52.9 (18/34) olarak bulundu. Bu istatistiksel olarak anlamlı degildi.(p>0.05) Siklus başına düşen gebelik oranları KS-IUI sikluslarinda %38.7 (12/31) ve rFSH-IUI sikluslarinda %35.2 (18/51) olarak bulundu. Bu sonuçlar istatistiki olarak anlamlı değildi.(p>0.05) Sonuçlar: Uygun hasta seçimi yapıldığı zaman KS-IUf uygulamasının infertilite tedavisinde en az rFSH-IUI uygulaması kadar başarılıdır. Tedavi maliyetleri gözönüne alındığında, daha önce klomifen sitrat tedavisi uygulanmamış olan hastalarda gonadotropinlere başlamadan önce birkaç siklus KS denenmesinin uygun olacağını düşünmekteyiz.

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Cite This Article

GÖRKEMLİ, H., AKYÜREK, C., AK, D., AKTAN, M., DUMAN, S. (2022). The results of intrauterin insemination in primary infertile couples inducted with 501U recombinant FSH versus 100 MG clomiphene citrate. Türk Fertilite Dergisi, Cilt: 10 - Sayı: 1, 48–52. https://ajindex.com/articles/623392

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References (1)

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