Journals / Journal of the Turkish-German Gynecological Association / 2010 / Cilt: 11 - Sayı: 3

Kumulus hücre kokültürünün ve kumulus destekli embryo transferinin embryonik gelişim ve gebelik oranlarına etkisi

Influence of cumulus cell coculture and cumulus-aided embryo transfer on embryonic development and pregnancy rates

Pages
121–126
Publication Date
2022-10-18
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

However, cumulus-aided embryo transfer does not produce an increase in implantation and pregnancy rates.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: In this study, we aimed to evaluate the influence of autologous cumulus oocyte complex (COC) coculture on embryonic development and quality, and investigate the implantation and pregnancy rates after cumulus-aided embryo transfer in the ICSI-ET cycles.
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Key Findings & Data:Group 1 consisted of 48 women undergoing ICSI, along with autologous cumulus embryo coculture and cumulus-aided emryo transfer.
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Conclusion & Impact:However, cumulus-aided embryo transfer does not produce an increase in implantation and pregnancy rates.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: In this study, we aimed to evaluate the influence of autologous cumulus oocyte complex (COC) coculture on embryonic development and quality, and investigate the implantation and pregnancy rates after cumulus-aided embryo transfer in the ICSI-ET cycles. Material and Methods: Ninety five consecutive infertile women undergoing their first cycle of IVF teratment were included in the study. The cases were divided into two groups. Group 1 consisted of 48 women undergoing ICSI, along with autologous cumulus embryo coculture and cumulus-aided emryo transfer. Group 2 comprised 47 consecutive patients who consented to undergo ICSI and in whom autologous cumulus embryo coculture and cumulus-aided embryo transfer were not performed. Implantation and pregnancy rates were compared between the two groups. Results: The demographic data and controlled ovarian hyperstimulation parameters were similar in the two groups. The fertilization and cleavage rates were found to be higher in group 1 when compared with group 2 (p=0.03 and 0.001, respectively). There were no statistical significant differences for the implantation and clinical pregnancy rates between the two groups. Conclusion: Usage of autologous COCs as coculture may improve fertilization and cleavage rates. However, cumulus-aided embryo transfer does not produce an increase in implantation and pregnancy rates.

Özet

Amaç: Bu çalışmada, otolog kumulus-oosit kompleks (COC) kokültürünün embryonik gelişim ve kalitesine etkisini değerlendirmek, ve ICSI-ET sikluslarında kumulus destekli embryo transferinin implantasyon ve gebelik oranlarına etkisini araştırmayı amaçladık. Gereç ve Yöntemler: Yardımla üreme tedavisinin ilk siklusunda olan 95 infertil kadın hasta çalışmaya dahil edildi. Vakalar iki alt gruba ayrıldı. Grup1 otolog embryo kokültürü ve kumulus destekli embryo ttransferi uygulanan 48 hastayı kapsadı. Diğer grup ise rutin ICSI tedavisi uygulanan 47 hastayı içerdi. Bu grupta otolog kumulus embryo kokültürü ve kumulus destekli embryo transferi uygulanmadı. İmplantasyon ve gebelik oranları iki grup arasında karşılaştırıldı. Bulgular: Demografik veriler ve kontrollü ovarian hiperstimulasyon parametreleri her iki grup arasında benzerdi. Fertilizasyon ve yarıklanma oranları grup1’de grup 2’den istatiksel olarak anlamlı derecede yüksek saptandı (sırasıyla p=0.03 ve 0.001). İmplantasyon ve gebelik oranları açısından her kik grup arasında istatiksel olarak anlamlı fark tespit edilmedi. Sonuç: Otolog kumulus-oosit kompleksinin kokültür olarak kullanılması fertilizasyon ve yarıklanma oranlarını arttırabilir. Bununla birlikte, kumulus destekli embryo transferi implantasyon ve gebelik oranlarına katkı sağlamamaktadır.

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Cite This Article

GÖRKEMLİ, H., AKTAN, M., ÖZDEMİR, S., CİHANGİR, N., DUMAN, S. (2022). Kumulus hücre kokültürünün ve kumulus destekli embryo transferinin embryonik gelişim ve gebelik oranlarına etkisi. Journal of the Turkish-German Gynecological Association, Cilt: 11 - Sayı: 3, 121–126. https://ajindex.com/articles/567768

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