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Journals / Türkderm Türk deri hastalıkları ve frengi arşivi / 2020 / Cilt: 54 - Sayı: 3

The evaluation of ovarian reserve and menstrual irregularities in female patients treated with systemic isotretinoin

Sistemik izotretinoin ile tedavi edilen kadın hastalarda over rezervinin ve menstrüel düzensizliklerin değerlendirilmesi

Utkan KIZILTAÇ
Emek KOCATÜRK
Pelin KUTEYLA CAN
Veli MİHMANLI
Ece Nur DEĞİRMENTEPE
Veysel SUCU
Pages
79–84
Publication Date
2022-11-06
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

AMH, FSH and TAFC were evaluated before and at 6th month of treatment in the treatment group, while AMH and FSH levels were evaluated in the control group.Results: Mean AMH level of treatment group at the 6th month of treatment was significantly lower than the level prior to treatment and that of the control group (p

📌 3 Key Takeaways

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Objective & Hypothesis:Background and Design: Isotretinoin is a widely used retinoid for the treatment of many dermatological conditions notably in acne with many known side effects.
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Key Findings & Data:Study group is consisted of 32 healthy control, 29 low-dose (0.4-0.6 mg/kg/day mean: 0.56±0.06) and 31 high-dose isotretinoin received patients (0.7-1.1 mg/kg/day mean: 0.94±0.11).
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Conclusion & Impact:AMH, FSH and TAFC were evaluated before and at 6th month of treatment in the treatment group, while AMH and FSH levels were evaluated in the control group.Results: Mean AMH level of treatment group at the 6th month of treatment was significantly lower than the level prior to treatment and that of the control group (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Background and Design: Isotretinoin is a widely used retinoid for the treatment of many dermatological conditions notably in acne with many known side effects. This study aims to investigate the effects of isotretinoin on anti-Mullerian hormone (AMH), follicle stimulating hormone (FSH) and total antral follicle count (TAFC) as the indicators of ovarian reserve (OR) and also aims to investigate the frequency of menstrual irregularities (MI).Materials and Methods: Ninety-two reproductive women were included in this prospective controlled study. Study group is consisted of 32 healthy control, 29 low-dose (0.4-0.6 mg/kg/day mean: 0.56±0.06) and 31 high-dose isotretinoin received patients (0.7-1.1 mg/kg/day mean: 0.94±0.11). AMH, FSH and TAFC were evaluated before and at 6th month of treatment in the treatment group, while AMH and FSH levels were evaluated in the control group.Results: Mean AMH level of treatment group at the 6th month of treatment was significantly lower than the level prior to treatment and that of the control group (p

Özet

Amaç: İzotretinoin, başta akne olmak üzere birçok dermatolojik hastalığın tedavisinde sıkça kullanılan ve birçok yan etkisi bilinen bir retinoiddir.Bu çalışma, aknesi olan kadın hastalarda izotretinoinin over rezervinin (OR) göstergeleri olan anti-Müllerian hormon (AMH), folikül stimüle edici hormon (FSH) ve total antral folikül sayılarına (TAFS) etkisini ve menstrüel düzensizliklerinin (MD) sıklığını araştırmayı amaçlamaktadır.Gereç ve Yöntem: Prospektif kontrollü olan bu çalışmaya üreme çağındaki 92 kadın dahil edildi. Çalışma, 32 sağlıklı kontrol, 29 düşük doz izotretinoin alan hasta (0,4-0,6 mg/kg/gün doz ortalaması: 0,56±0,06) ve 31 yüksek doz izotretinoin alan hastadan (0,7-1,1 mg/kg/gün doz ortalaması: 0,94±0,11) oluşmaktaydı. Tedavi grubunun serum AMH, FSH ve TAFS değerleri tedavi öncesi ve tedavinin altıncı ayı için, kontrol grubunun ise serum AMH ve FSH seviyeleri değerlendirilmiştir.Bulgular: Tedavi grubunun tedavinin altıncı ayındaki ortalama serum AMH değerleri tedavi öncesinden ve kontrol grubundan istatistiksel olarak düşük bulunmuştur (p

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Cite This Article

KIZILTAÇ, U., KOCATÜRK, E., CAN, P. K., MİHMANLI, V., DEĞİRMENTEPE, E. N., SUCU, V. (2022). The evaluation of ovarian reserve and menstrual irregularities in female patients treated with systemic isotretinoin. Türkderm Türk deri hastalıkları ve frengi arşivi, Cilt: 54 - Sayı: 3, 79–84. https://ajindex.com/articles/622493

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