Journals / Türkderm Türk deri hastalıkları ve frengi arşivi / 2021 / Cilt: 55 - Sayı: 2

The impact of vitamin D deficiency and autoimmunity on chronic spontaneous urticaria severity

Vitamin D eksikliğinin ve otoimmünitenin kronik spontan ürtikerşiddetine etkisi

Pages
70–74
Publication Date
2022-11-06
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

Results: Angioedema was more frequent and UAS7 was higher in ASST-positive patients than ASST-negative patients (p=0.035, p=0.018, respectively).

📌 3 Key Takeaways

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Objective & Hypothesis:Background and Design: In this study, we investigated the role of vitamin D deficiency and autoimmunity in chronic spontaneous urticaria (CSU) etiopathogenesis and their impact on the disease severity.
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Key Findings & Data:Materials and Methods: Sixty patients with CSU aged between 18 and 65 years were enrolled to the study.
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Conclusion & Impact:Results: Angioedema was more frequent and UAS7 was higher in ASST-positive patients than ASST-negative patients (p=0.035, p=0.018, respectively).
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Background and Design: In this study, we investigated the role of vitamin D deficiency and autoimmunity in chronic spontaneous urticaria (CSU) etiopathogenesis and their impact on the disease severity. Materials and Methods: Sixty patients with CSU aged between 18 and 65 years were enrolled to the study. The control group comprised 40 healthy individuals who had no episodes of urticaria or any other chronic diseases. An autologous serum skin test (ASST) was performed in all patients. In addition, 25 hydroxyvitamin D, thyroid autoantibodies (TA), anti-nuclear antibody (ANA), and basophils were evaluated in all groups. Urticaria activity score-7 (UAS7) and dermatological quality of life index (DLQI) of all patients were examined. Results: Angioedema was more frequent and UAS7 was higher in ASST-positive patients than ASST-negative patients (p=0.035, p=0.018, respectively).

Özet

Amaç: Bu çalışmada kronik spontan ürtiker (KSÜ) etiyopatogenezinde D vitamini eksikliği ve otoimmünitenin rolünü ve bunların hastalık şiddetine etkisini araştırmayı amaçladık. Gereç ve Yöntem: On sekiz-altmış beş yaşları arasındaki 60 KSÜ hastası çalışmaya dahil edildi. Kontrol grubu daha önce ürtiker atağı geçirmemiş ve kronik hastalığı olmayan 40 sağlıklı bireyden oluşuyordu. Tüm hastalara otolog serum deri testi (ASST) yapıldı. Tüm gruplarda 25 hidroksivitamin D, tiroid otoantikorları (TA), antinükleer antikor (ANA) ve bazofiller değerlendirildi. Tüm hastaların ürtiker aktivite skoru-7 (UAS7) ve dermatolojik yaşam kalitesi indeksi (DLQI) incelendi. Bulgular: ASST pozitif olan hastalarda anjiyoödem, ASST negatif olanlara göre daha sık ve UAS7 daha yüksekti (sırasıyla; p=0,035, p=0,018).

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Cite This Article

ERDEM, M. T., METİN, N. (2022). The impact of vitamin D deficiency and autoimmunity on chronic spontaneous urticaria severity. Türkderm Türk deri hastalıkları ve frengi arşivi, Cilt: 55 - Sayı: 2, 70–74. https://ajindex.com/articles/622459

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