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Journals / Turkish Journal of Clinics and Laboratory / 2026 / Cilt: 16 Sayı: 2

HER2-low expression in patients with hormone receptor positive and HER2 negative advanced breast cancer treated with ribociclib or palbociclib in combination with endocrine therapy

Hormon reseptörü pozitif, HER2 negatif metastatik meme kanseri tanısıyla ribosiklib veya palbosiklib ile letrozol kombinasyon tedavisi verilen hastalarda HER2-düşük ekspresyonunun önemi

Seda Kahraman(UNIVERSITY OF HEALTH SCIENCES, ANKARA GÜLHANE HEALTH RESEARCH CENTER)0000-0002-5328-6554
Mutlu Hızal(ANKARA BILKENT CITY HOSPITAL)0000-0001-5147-4431
Özge Gümüşay(ACIBADEM UNIVERSITY, SCHOOL OF MEDICINE)0000-0002-6236-9829
Gül Başaran(ACIBADEM UNIVERSITY, SCHOOL OF MEDICINE)0000-0002-0775-6180
Mustafa Seyyar(KOCAELI UNIVERSITY, SCHOOL OF MEDICINE)0000-0002-4841-7994
Elif Sahin(KOCAELI UNIVERSITY, SCHOOL OF MEDICINE)0000-0002-1976-3951
Devrim Çabuk(KOCAELI UNIVERSITY, SCHOOL OF MEDICINE)0000-0002-7871-6311
Alper Yaşar(MARMARA UNIVERSITY, SCHOOL OF MEDICINE)0000-0001-8814-8947
Vedat Bayoğlu(MARMARA UNIVERSITY, SCHOOL OF MEDICINE)0000-0002-0481-1084
Ertuğrul Bayram(CUKUROVA UNIVERSITY, FACULTY OF MEDICINE)0000-0001-8713-7613
Semra Paydaş(CUKUROVA UNIVERSITY, FACULTY OF MEDICINE)0000-0003-4642-3693
Burcu Gülbağcı(SAKARYA UNIVERSITY, SCHOOL OF MEDICINE)0000-0002-5720-8254
İlhan Hacıbekiroğlu(SAKARYA UNIVERSITY, SCHOOL OF MEDICINE)0000-0002-0333-7405
Burçin Çakan Demirel(PAMUKKALE UNIVERSITY, SCHOOL OF MEDICINE)0000-0003-0734-0692
Arzu Yaren(PAMUKKALE UNIVERSITY, SCHOOL OF MEDICINE)0000-0003-1436-8650
Melike Özçelik(UNIVERSITY OF HEALTH SCIENCES, İSTANBUL ÜMRANİYE HEALTH RESEARCH CENTER)0000-0003-0406-715X
Funda Yılmaz(SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, ANKARA DR. ABDURRAHMAN YURTASLAN ONKOLOJİ SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ)0000-0002-7409-5730
Mutlu Doğan(SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, ANKARA DR. ABDURRAHMAN YURTASLAN ONKOLOJİ SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ)0000-0001-9359-3770
Nail Paksoy(ISTANBUL UNIVERSITY, İSTANBUL FACULTY OF MEDICINE)0000-0003-4636-2595
Adnan Aydıner(ISTANBUL UNIVERSITY, İSTANBUL FACULTY OF MEDICINE)0000-0002-1104-5840
Olcun Umit Unal(UNIVERSITY OF HEALTH SCIENCES, İZMİR TEPECİK HEALTH RESEARCH CENTER)0000-0001-7698-3574
Murat Keser(UNIVERSITY OF HEALTH SCIENCES, İZMİR TEPECİK HEALTH RESEARCH CENTER)0000-0003-3834-0863
Esra Aydın(RECEP TAYYIP ERDOGAN UNIVERSITY, SCHOOL OF MEDICINE)0000-0003-0210-3153
Erkan Kayıkçıoğlu(SULEYMAN DEMIREL UNIVERSITY, SCHOOL OF MEDICINE)0000-0002-7401-5446
Bülent Çetin(SULEYMAN DEMIREL UNIVERSITY, SCHOOL OF MEDICINE)0000-0001-8628-0864
Serkan Menekşe(Manisa City Hospital)0000-0002-2134-2128
Engin Kut(Manisa City Hospital)0000-0002-5328-5607
Kerem Okutur(ISTANBUL AREL UNIVERSITY, SCHOOL OF MEDICINE)0000-0002-8079-7739
Naziyet Köse Baytemur(Memorial Ankara Hospital)0000-0002-3587-2517
Umut Demirci(Memorial Ankara Hospital)0000-0002-4833-6721
Cihan Erol(YILDIRIM BEYAZIT UNIVERSITY, SCHOOL OF MEDICINE)0000-0003-3155-8798
Fatih Selçuk Biricik(KOC UNIVERSITY, SCHOOL OF MEDICINE)0000-0002-1273-1674
Deniz Işık(VM Medical Park Kocaeli Hospital)0000-0003-4398-5148
Özgecan Dülgar(Necip Fazil City Hospital)0000-0002-0678-4024
Teoman Sakalar(Necip Fazil City Hospital)0000-0003-2749-9414
Başak Oyan Uluç(ACIBADEM UNIVERSITY, SCHOOL OF MEDICINE)0000-0002-6623-6273
Sena Ece Davarcı(AFYONKARAHISAR HEALTH SCIENCES UNIVERSITY, SCHOOL OF MEDICINE)0000-0003-1142-9411
Hacer Demir(AFYONKARAHISAR HEALTH SCIENCES UNIVERSITY, SCHOOL OF MEDICINE)0000-0003-1235-9363
Ömer Acar(CELAL BAYAR UNIVERSITY, FACULTY OF MEDICINE)0000-0003-4408-1976
Atike Pinar Erdoğan(MANISA CELAL BAYAR UNIVERSITY, SCHOOL OF MEDICINE)0000-0003-4859-7574
Sibel Oyucu Orhan(ULUDAG UNIVERSITY, SCHOOL OF MEDICINE)0000-0001-8217-3471
Erdem Çubukçu(ULUDAG UNIVERSITY, SCHOOL OF MEDICINE)0000-0002-0070-0889
Dinçer Aydın(UNIVERSITY OF HEALTH SCIENCES, KOCAELİ DERİNCE HEALTH RESEARCH CENTER)0000-0002-0662-512X
Yusuf Karakas(Acıbadem Bodrum Hospital)0000-0003-0205-4590
Hakan Yücel(GAZIANTEP UNIVERSITY, SCHOOL OF MEDICINE)0000-0003-4711-1405
Gülhan Özkanlı(CANAKKALE ONSEKIZ MART UNIVERSITY, SCHOOL OF MEDICINE)0000-0003-3912-7191
Eda Eylemer Mocan(ANKARA UNIVERSITY, SCHOOL OF MEDICINE)0000-0003-0429-8142
Denizcan Güven(HACETTEPE UNIVERSITY, FACULTY OF MEDICINE)0000-0002-6924-9467
Orhan Önder Eren(SELCUK UNIVERSITY, SCHOOL OF MEDICINE)0000-0001-6397-8207
Burak Bilgin(Konya City Hospital)0000-0003-1717-8246
Nurhan Önal Kalkan(VAN YUZUNCU YIL UNIVERSITY, SCHOOL OF MEDICINE)0000-0002-2823-332X
Yakup İriağaç(NAMIK KEMAL UNIVERSITY, SCHOOL OF MEDICINE)0000-0001-7411-1705
Muhammed Muhiddin Er(NECMETTIN ERBAKAN UNIVERSITY, MERAM SCHOOL OF MEDICINE)0000-0002-0583-0295
Nilgün Yıldırım(FIRAT UNIVERSITY, SCHOOL OF MEDICINE)0000-0001-8198-2605
Merve Keskinkılıç(DOKUZ EYLUL UNIVERSITY, SCHOOL OF MEDICINE)0000-0002-3342-3144
Özlem Özdemir(SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, İZMİR BOZYAKA SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ)0000-0003-2520-5953
Veli Sunar(Aydın Atatürk City Hospital)0000-0003-4672-4621
Nazım Serdar Turhal(Anadolu Medical Center)0000-0002-1013-5676
Berna Bozkurt Duman(SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, ADANA ŞEHİR SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ)0000-0003-0295-6295
Muhammed Bülent Akıncı(YILDIRIM BEYAZIT UNIVERSITY, SCHOOL OF MEDICINE)0000-0001-7575-9925
Musa Barış Aykan(UNIVERSITY OF HEALTH SCIENCES, GÜLHANE SCHOOL OF MEDICINE, GÜLHANE MEDICINE PR. (ANKARA))0000-0001-7538-9119
Müge Karaoğlanoğlu(Ordu State Hospital,)0000-0003-0839-8191
Özlem Doğan(Etlik City Hospital)0000-0003-1023-8410
Ali İnal(Mersin City Hospital)0000-0001-9510-9858
Mehmet Ali Şendur(YILDIRIM BEYAZIT UNIVERSITY, SCHOOL OF MEDICINE)0000-0001-7021-6139
Pages
255–262
Publication Date
2025-06-30
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: HER2-low status had no statistically significant impact on survival in patients treated with palbociclib or ribociclib plus letrozole.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Aim: Hormone receptor (HR)-positive, human epidermal growth factor 2 (HER2)-negative breast cancer which represents the most common subgroup of metastatic breast cancer (MBC).
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Key Findings & Data:Recently, further subclassification for HER2-negative tumors has emerged as HER2-low.
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Conclusion & Impact:Conclusion: HER2-low status had no statistically significant impact on survival in patients treated with palbociclib or ribociclib plus letrozole.
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:CDK4/6 inhibitörleri · metastatik meme kanseri · HER2-düşük ekspresyonu

Abstract

Aim: Hormone receptor (HR)-positive, human epidermal growth factor 2 (HER2)-negative breast cancer which represents the most common subgroup of metastatic breast cancer (MBC). Recently, further subclassification for HER2-negative tumors has emerged as HER2-low. There is limited knowledge regarding the effect of HER2-low expression on outcomes of patients with HR-positive and HER2-negative MBC treated with CDK 4/6 inhibitors plus hormonal therapy. Therefore, we evaluated survival parameters according to HER2-low status for this patient group in this study. Material and Methods: As the Turkish Oncology Group (TOG) Project, retrospectively collected data from 423 patients with HR-positive/HER2-negative MBC treated with ribociclib and palbociclib plus letrozole therapy was assessed. Included patients had metastatic first-line therapy and endocrine-sensitive disease. Survival outcomes were compared between HER2-negative and HER2-low patient groups. Conclusion: HER2-low status had no statistically significant impact on survival in patients treated with palbociclib or ribociclib plus letrozole.

Özet

Amaç: Metastatik meme kanserinin (MMK) en yaygın alt grubunu temsil eden hormon reseptörü (HR) pozitif, insan epidermal büyüme faktörü 2 (HER2) negatif meme kanseridir. Yakın dönemde HER2 negatif tümörler için daha ileri bir alt sınıflandırma olarak HER2-düşük terimi ortaya çıkmıştır. HER2-düşük ekspresyonunun, CDK 4/6 inhibitörleri ve hormonal tedavi kombinasyonuyla tedavi edilen HR-pozitif/HER2-negatif MMK'li hastaların sonuçları üzerindeki etkisine ilişkin sınırlı bilgi bulunmaktadır. Bu nedenle çalışmamızda bu hasta grubu için HER2-düşük durumuna göre sağkalım parametrelerini değerlendirdik. Gereç ve Yöntemler: Türk Onkoloji Grubu (TOG) Projesi olarak Türkiye genelindeki 43 farklı tıbbi onkoloji merkezinden retrospektif olarak veri toplandı. Haziran 2016 ile Ağustos 2022 arasındaki dönemde Ribosiklib veya Palbosiklib ile letrozol kombinasyon tedavisi verilmiş HR-pozitif/HER2-negatif MMK'li 423 hastadan retrospektif olarak toplanan veriler değerlendirildi. Dahil edilen hastalar metastatik birinci basamak olarak tedaviye başlanan ve endokrin duyarlı hastalığa sahipti. Hastaların sağkalım sonuçları, HER2-negatif ve HER2- düşük hasta grubu arasında kıyaslandı. Sonuç: HER2-düşük durumu, palbosiklib veya ribosiklib ile letrozol tedavisi alan hastalarda sağkalım üzerinde istatistiksel olarak anlamlı bir etki göstermedi.

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Cite This Article

Kahraman, S., Hızal, M., Gümüşay, Ö., Başaran, G., Seyyar, M., Sahin, E., Çabuk, D., Yaşar, A., Bayoğlu, V., Bayram, E., Paydaş, S., Gülbağcı, B., Hacıbekiroğlu, İ., Demirel, B. Ç., Yaren, A., Özçelik, M., Yılmaz, F., Doğan, M., Paksoy, N., Aydıner, A., Unal, O. U., Keser, M., Aydın, E., Kayıkçıoğlu, E., Çetin, B., Menekşe, S., Kut, E., Okutur, K., Baytemur, N. K., Demirci, U., Erol, C., Biricik, F. S., Işık, D., Dülgar, Ö., Sakalar, T., Uluç, B. O., Davarcı, S. E., Demir, H., Acar, Ö., Erdoğan, A. P., Orhan, S. O., Çubukçu, E., Aydın, D., Karakas, Y., Yücel, H., Özkanlı, G., Mocan, E. E., Güven, D., Eren, O. Ö., Bilgin, B., Kalkan, N. Ö., İriağaç, Y., Er, M. M., Yıldırım, N., Keskinkılıç, M., Özdemir, Ö., Sunar, V., Turhal, N. S., Duman, B. B., Akıncı, M. B., Aykan, M. B., Karaoğlanoğlu, M., Doğan, Ö., İnal, A., Şendur, M. A. (2025). HER2-low expression in patients with hormone receptor positive and HER2 negative advanced breast cancer treated with ribociclib or palbociclib in combination with endocrine therapy. Turkish Journal of Clinics and Laboratory, Cilt: 16 Sayı: 2, 255–262. https://doi.org/10.18663/tjcl.1639022

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