Journals / Türkderm-Deri Hastalıkları ve Frengi Arşivi / 2006 / Cilt: 40 - Sayı: 2

Prolactin levels in patients with pemphigus

Pemfigus hastalarında serum prolaktin düzeyleri

Pages
52–55
Publication Date
2022-11-05
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Serum PRL levels of the male patients was not significantly enhanced compared with that found in controls (p>0.05) while the female patients' was statistically significantly increased (p

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Background and Design: It has been demonstrated that prolactin has an important role in autoimmunity and autoimmune diseases.
📊
Key Findings & Data:MATERIALS-METHODS: Serum PRL levels were determined by immunoassay methods in 44 patients with pemphigus and in control group of 44 individuals.
💡
Conclusion & Impact:Serum PRL levels of the male patients was not significantly enhanced compared with that found in controls (p>0.05) while the female patients' was statistically significantly increased (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Background and Design: It has been demonstrated that prolactin has an important role in autoimmunity and autoimmune diseases. The aim of this study was to evaluate the level of prolactin (PRL) in pemphigus patients and its relation with the disease and disease activity. MATERIALS-METHODS: Serum PRL levels were determined by immunoassay methods in 44 patients with pemphigus and in control group of 44 individuals. RESULTS: Hyperprolactinemia was 10.2% for pemphigus patients versus 0% for healthy controls (p= 0.058). Serum PRL levels of the male patients was not significantly enhanced compared with that found in controls (p>0.05) while the female patients' was statistically significantly increased (p

Özet

Prolaktinin (PRL) otoimmünite ve otoimmün hastalıklarla ilişkili olduğu gösterilmiştir. Bu çalışmada otoimmün bir hastalık olan pemfigusta serum PRL düzeylerinin hastalık ve hastalık aktivitesi ile ilişkisini saptamak amaçlandı. Pemfigus tanısı alan 40 hasta ile 44 kişiden oluşan kontrol grubunda serum PRL düzeyleri immünoassay yöntem ile ölçüldü. Hiperprolaktinemi, pemfiguslu hastalarda %10.2, kontrol grubunda %0 olarak saptandı (p=0.058). Erkek hastalarda serum PRL düzeyleri kontrol grubuna göre anlamlı olarak yüksek bulunmazken (p>0.05), kadın hastalarda anlamlı derecede yüksek bulundu (p

🔖

Cite This Article

KAVALA, M., SARIGÜL, Ş., KOCATÜRK, Ö. E. (2022). Prolactin levels in patients with pemphigus. Türkderm-Deri Hastalıkları ve Frengi Arşivi, Cilt: 40 - Sayı: 2, 52–55. https://ajindex.com/articles/622155

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (16)

  1. Udey MC, Stanley JR. Pemphigus: Diseases of antidesmosomal autoimmunity. JAMA 1999; 282:572-76
  2. Vera-Lastra O, Jara LJ, Espinoza LR: Prolactin and autoimmunity. Autoimmun Rev 2002;1(6):360-364
  3. Yu-Lee LY: Prolactin Modulation of Immune and Inflammatory Responses. Recent Prog Horm Res 2002;57:435-455
  4. Do¤usan Z, Hooghe R, Verdood P, Hooghe-Peters EL: Cytokine- like effects of prolactin in human mononuclear and polimorpho- nuclear leukocytes. J Neuroimmunol 2001;120(1-2):58-66
  5. Matera L, Mori M, Geuna M, Buttiglieri S, Palestro G: Prolactin in autoimmunity and anti-tumor defence. J Neuroimmunol 2000;109:47-55
  6. Jacobi AM, Rohde W et al: Prolactin enhances the in vitro pro- duction of IgG in peripheral blood mononuclear cells from pati- ents with systemic lupus erythematosus but not from healthy controls. Ann Rheum Dis 2001;60:242-247
  7. Pacilio M, Migliaresi S, Meli R, Ambrosone L, Bigliardo B, Di Car- lo R: Elevated bioactive prolactin levels in systemic lupus erythe- matosus - association with disease activity. J Rheumatol 2001;28:2216-2221
  8. Velkeniers B, Dogusan Z, Naessens F, Hooghe R, Hooghe-Peters EL: Prolactin, growth hormone and immune system in humans. Cell Mol Life Sci 1998;54:1102-1108
  9. Barzegari M, Chamse DS, Kiafar: Comparison of serum prolactin levels between autoimmune skin patients and a control group. 20th World Congress of Dermatology, Paris, France, July 1-5, 2000
  10. Gutierrez MA, Molina JF, et al: Prolactin-induced immunoglobu- lin and autoantibody production by peripheral blood mononuc- lear cells from systemic lupus erythematosus and normal indivi- duals. Int Arch Allergy Immunol 1996;109:229-235
  11. Chang DM, Chang CC, Kuo SY, Chu SJ, Chang MI: Hormonal pro- files and immunological studies of male lupus in Twain. Clin Rhe- umatol 1999;18(2):158-162
  12. Odom BO, James W, Berger T: Chronic blistering dermatoses. Andrew's Diseases of the Skin
  13. Bask›. Philadelphia, Saunders Company, 2000;574-605
  14. Sontheimer RD: Lupus erythematosus. Fitzpatrick's dermatology in general medicine. Ed: Freedberg IM, Eisen AZ, Wolff K. 5th ed. New York, Mc Graw Hill, 1999;1993-2009
  15. Eming R, Budinger L, Riechers R, Christensen O, Bohlen H, Kalish R, Hertl M: Frequency analysis of autoreactive T-helper 1 and T- helper 2 cells in bullous pemphigoid and pemphigus vulgaris by enzyme-linked immunospot assay. Br J Dermatol 2000;143(6):1279-1282
  16. Jara LJ, Lavalle C, Fraga A, Gomez-Sanchez C, Silveria LH, Marti- nez-Osuna P: P