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Journals / Göztepe Tıp Dergisi / 2010 / Cilt: 25 - Sayı: 3

Serum leptin levels in psoriasis vulgaris patients, correlation with BMI and disease severity

Psoriasis vulgarisli hastalarda serum leptim düzeyleri, BMI ve hastalık şiddeti ile ilişkisi

İlkin ZİNDANCI
Yasin BAYRAKTAROĞLU
Şermin ACAR
Sibel SÜDOĞAN
Mukaddes KAVALA
Zafer TÜRKOĞLU
Melek KOÇ
Burç CAN
Pages
111–115
Publication Date
2022-10-17
DOI
—
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

Results: The mean serum leptin concentration was statistically different in patients with psoriasis (9.48 ng/ml) when compared with that in healthy control subjects (5.94 ng/ml) (p

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: Psoriasis is considered to be a T-cell-mediated inmunological skin disease, with a preponderance of type I cytokines.
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Key Findings & Data:Leptin, promotes type I cytokine synthesis and supresses type 2 cytokine production.
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Conclusion & Impact:Results: The mean serum leptin concentration was statistically different in patients with psoriasis (9.48 ng/ml) when compared with that in healthy control subjects (5.94 ng/ml) (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: Psoriasis is considered to be a T-cell-mediated inmunological skin disease, with a preponderance of type I cytokines. Leptin, promotes type I cytokine synthesis and supresses type 2 cytokine production. In this study we aimed to investigate serum leptin levels in psoriasis patients, association between body mass index (BMI) and disease severity. Material and Methods: Eighty patients with psoriasis (31 male, 49 female) and 80 age and sex matched healthy control subjects (32 male, 48 female) were recruited in this study. The body mass index (BMI) was calculated for subjects. Serum leptin levels was determined with ELISA method. Results: The mean serum leptin concentration was statistically different in patients with psoriasis (9.48 ng/ml) when compared with that in healthy control subjects (5.94 ng/ml) (p

Özet

Amaç: Psoriasis tip I sitokinlerin baskın olduğu T-hücre ilişkili immunolojik bir deri hastalığıdır. Leptin T hücre üzerindeki Th1 sitokin sentezini uyarıcı ve Th 2 sitokin sentezini baskılayıcı etkileri ile psoriasis immunopatogenezinde rolü olabilecek vücut ağırlığını düzenleyen bir hormondur. Bu çalışmada leptinin psoriasisli hastalarda serum düzeyini, vücut kitle indeksleri [body mass index (BMI)] ve hastalık şiddeti ile ilişkisini araştırdık. Gereç ve Yöntem: Psoriasisli 80 hasta (31 erkek, 49 kadın; yaş 43.13±13.13 yıl/SD) ve yaş, cinsiyet uyumlu sağlıklı 80 kişi (32 erkek, 48 kadın; yaş 42.91±12.97 yıl/SD) dahil edildi. Çalışmaya katılan bütün bireylerin BMI’leri hesaplandı. Serum leptin düzeyleri ELISA yöntemi ile ölçüldü. Bulgular: Psoriasisli hastaların ortalama serum leptin düzeyleri (9.48 ng/ml) ile sağlıklı kontrol grubunun serum leptin düzeyleri (5.94 ng/ml) karşılaştırıldığında istatistiksel olarak aradaki fark anlamlı bulundu (p

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Cite This Article

ZİNDANCI, İ., BAYRAKTAROĞLU, Y., ACAR, Ş., SÜDOĞAN, S., KAVALA, M., TÜRKOĞLU, Z., KOÇ, M., CAN, B. (2022). Serum leptin levels in psoriasis vulgaris patients, correlation with BMI and disease severity. Göztepe Tıp Dergisi, Cilt: 25 - Sayı: 3, 111–115. https://ajindex.com/articles/526163

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