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Journals / Türkderm-Deri Hastalıkları ve Frengi Arşivi / 2007 / Cilt: 41 - Sayı: 2

Expression of cell proliferation markers in benign, premalignant and malignant lesions and human papillomavirus isolation

Benin, premalin ve malin lezyonlarda hücre proliferasyon belirleyicilerinin ekspresyonu ve insan papilloma virus izolasyonu

Rıza DURMAZ
Gamze SERARSLAN
Sevgi BAKARİŞ
Barış OTLU
Esin ATİK
Pages
57–62
Publication Date
2022-11-05
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In the lesions, the Ki-67, p21 and bcl-2 expressions were found to be increased respectively: KA

📌 3 Key Takeaways

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Objective & Hypothesis:Background and Design: This study was designed to investigate the role of proliferation markers in various benign, premalignant and malignant skin lesions and also aimed to detect HPV positivity in these lesions.
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Key Findings & Data:MATERIAL-METHOD: A total of 62 paraffin blocks [12 seborrheic keratoses (SK), 10 keratoacantoma (KA), 8 actinic keratoses (AK), 22 basal cell carcinoma (BCC), and 10 squamous cell carcinoma (SCC)] were included in the study.
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Conclusion & Impact:In the lesions, the Ki-67, p21 and bcl-2 expressions were found to be increased respectively: KA
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Background and Design: This study was designed to investigate the role of proliferation markers in various benign, premalignant and malignant skin lesions and also aimed to detect HPV positivity in these lesions. MATERIAL-METHOD: A total of 62 paraffin blocks [12 seborrheic keratoses (SK), 10 keratoacantoma (KA), 8 actinic keratoses (AK), 22 basal cell carcinoma (BCC), and 10 squamous cell carcinoma (SCC)] were included in the study. Specimens were studied immunohistochemically for the expression of Ki-67, p21 and bcl-2. PCR was performed to detect HPV DNA. RESULTS: HPV positivity was detected in two tissues of BCC (HPV type-16). In the lesions, the Ki-67, p21 and bcl-2 expressions were found to be increased respectively: KA

Özet

AMAÇ: Bu çalışmada çeşitli benin, premalin ve malin deri lezyonlarında proliferasyon belirleyicilerinin rolü ve bu lezyonlarda insan papilloma virusu (HPV) pozitifliğinin saptanması amaçlandı. GEREÇ-YÖNTEM: Çalışmaya, parafin bloktaki 62 doku [12 seboreik keratoz (SK), 10 keratoakantom (KA), 8 aktinik keratoz (AK), 22 bazal hücreli karsinom (BHK) ve 10 skuamöz hücreli karsinom (SHK)] alındı. Doku örnekleri, Ki-67, p21 ve bcl-2 ekspresyonunu belirlemek amacıyla, immünohistokimyasal yöntemle çalışıldı. HPV DNA’sını tespit etmek için PCR uygulandı. BULGULAR: BHK tanısı almış olan iki dokuda HPV (tip-16) pozitifliği saptandı. Lezyonlarda Ki-67, p21 ve bcl-2 ekspresyonu sırası ile şu şekildeydi: KA

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Cite This Article

DURMAZ, R., SERARSLAN, G., BAKARİŞ, S., OTLU, B., ATİK, E. (2022). Expression of cell proliferation markers in benign, premalignant and malignant lesions and human papillomavirus isolation. Türkderm-Deri Hastalıkları ve Frengi Arşivi, Cilt: 41 - Sayı: 2, 57–62. https://ajindex.com/articles/622154

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