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Journals / Türkderm-Deri Hastalıkları ve Frengi Arşivi / 2010 / Cilt: 44 - Sayı: 4

IL-2R, IL-6 and IL-8 levels in Behçet's disease

Behçet hastalığında IL-2R, IL-6 ve IL-8 levels

Kamer GÜNDÜZ
Işıl İNANIR
Timur PIRILDAR
Ece ONUR
Ahmet VAR
Pages
213–215
Publication Date
2022-11-05
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

IL-8 and CRP levels were increased in patient with active BD (p

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Background and Design: Immunological factors are considered to have an important role in the multifactorial ethiopathogenesis of Behçet’s disease (BD).
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Key Findings & Data:Especially, Th1 cells function by expressing proinflammatory cytokines and neutrophil-attracting chemokines.
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Conclusion & Impact:IL-8 and CRP levels were increased in patient with active BD (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Background and Design: Immunological factors are considered to have an important role in the multifactorial ethiopathogenesis of Behçet’s disease (BD). Especially, Th1 cells function by expressing proinflammatory cytokines and neutrophil-attracting chemokines. Levels of IL-2R, IL-6 and IL-8 were evaluated in patients with BD in this study. Material and Method: Sixty-six patients with BD (36 with inactive and 30 with active) composed the study group and 22 subjects – the control group. Cytokine analyses were done with ELISA method by using commercial kits. ESR and CRP levels were also measured. Results: IL-2R, IL-6 and IL-8 levels in all patients, including the inactive ones, were not different from those in controls. CRP and ESR levels in patients were higher than in controls. IL-8 and CRP levels were increased in patient with active BD (p

Özet

Amaç: İmmunolojik faktörler Behçet hastalığının multifaktöryel etyopatogenezinde önemli rol oynamaktadırlar. Özellikle Th1 hücreleri proinflamatuvar sitokinler ve nötrofil çekici kemokinler açığa çıkararak işlev görürler. Bu çalışmada Behçet hastalarında IL-2R, IL-6 ve IL-8 düzeyleri araştırılmıştır. Gereç ve Yöntem: Altmış-altı Behçetli hasta (36 inaktif ve 30 aktif) ve 22 sağlıklı kontrol çalışma grubunu oluşturmaktaydı. Sitokin analizleri ticari kitler kullanılarak ELISA yöntemi ile yapılmıştır. Ayrıca eritrosit sedimentasyon hızı (ESH) ve C-reaktif protein (CRP) çalışılmıştır. Bulgular: Tüm hastaların ve inaktif olanların IL-2R, IL-6 ve IL-8 düzeyleri kontrollerden farklı değildi. Hastalarda CRP ve ESR değerleri kontrollerden yüksekti. İnaktiflerle karşılaştırıldığında aktif hasta grubunda, IL-8 ve CRP düzeyleri artmıştı (p

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Cite This Article

GÜNDÜZ, K., İNANIR, I., PIRILDAR, T., ONUR, E., VAR, A. (2022). IL-2R, IL-6 and IL-8 levels in Behçet's disease. Türkderm-Deri Hastalıkları ve Frengi Arşivi, Cilt: 44 - Sayı: 4, 213–215. https://ajindex.com/articles/622009

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