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Journals / Türkderm-Deri Hastalıkları ve Frengi Arşivi / 2010 / Cilt: 44 - Sayı: 4

Leptin levels in patients with Behçet's disease

Behçet hastalarında leptin düzeyleri

Ece ONUR
Kamer GÜNDÜZ
Işıl İNANIR
Timur PIRILDAR
Nesrin ÖLÇER
Ahmet VAR
Pages
209–212
Publication Date
2022-11-05
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: Leptin might have a possible role in the pathogenesis of Behcet’s disease.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Background and Design: Leptin is a hormone, which regulates neuroendocrine function and also is involved in inflammatory processes.
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Key Findings & Data:Material and Method: Fifty-three patients with Behçet’s disease (28 active and 25 inactive) composed the study group and 22 subjects-the control group.
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Conclusion & Impact:Conclusion: Leptin might have a possible role in the pathogenesis of Behcet’s disease.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Background and Design: Leptin is a hormone, which regulates neuroendocrine function and also is involved in inflammatory processes. Proinflammatorycytokines, important inducers in the pathogenesis of Behçet’s disease, up-regulate the leptin levels. In this study, we aimed to compare leptin levels in patients with Behcet’s disease to those in controls and to investigate the correlation between leptin levels and disease activity. Material and Method: Fifty-three patients with Behçet’s disease (28 active and 25 inactive) composed the study group and 22 subjects-the control group. Leptin analyses were done by ELISA method using commercial kits. Erythrocyte sedimentation rate and C-reactive protein levels were also measured. Results: Leptin levels were increased in patients with Behçet’s disease compared to controls. Leptin did not correlate with disease activity. Conclusion: Leptin might have a possible role in the pathogenesis of Behcet’s disease.

Özet

Amaç: Leptin aynı zamanda inflamatuvar süreçlerde de yeralan bir nöroendokrin hormondur. Behçet hastalığının patogenezinde önemli bir uyarıcı olan proinflamatuvar sitokinler leptin düzeylerini düzenlerler. Bu çalışmada, Behçet hastalarında leptin düzeylerinin kontrollerle karşılaştırılması ve hastalık aktivitesi ile korelasyonu amaçlanmıştır. Gereç ve Yöntem: Elli üç Behçet hastası (28 aktif ve 25 inaktif) ve 22 kontrol çalışma grubunu oluşturmuştur. Leptin tayinleri ticari kitler kullanılarak ELİSA yöntemi ile çalışılmıştır. Eritrosit sedimentasyon hızı ve C-reaktif protein de saptanmıştır. Bulgular: Leptin düzeyleri Behçetli hastalarda kontrollere kıyasla artmıştı, ancak hastalık aktivitesi ile korele değildi. Sonuç: Leptinin Behçet hastalığı patogenezinde bir rolü olabilir.

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Cite This Article

ONUR, E., GÜNDÜZ, K., İNANIR, I., PIRILDAR, T., ÖLÇER, N., VAR, A. (2022). Leptin levels in patients with Behçet's disease. Türkderm-Deri Hastalıkları ve Frengi Arşivi, Cilt: 44 - Sayı: 4, 209–212. https://ajindex.com/articles/622033

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