SavedAdd your journal

Journals / Türk Biyokimya Dergisi / 2000 / Cilt: 25 - Sayı: 1

The effects of postmenopausal hormone replacement therapy to serum lipoprotein A levels and its relation with the coronary artery diseases

Postmenapozal hormon replasman tedavisinin lipid profiline etkisi

Banu ÖNVURAL
Ata ÖNVURAL
Nilüfer ÇELİK
Önder ÇELİK
Pages
15–20
Publication Date
2022-11-05
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Only in HRT group decrease in serum Lp-a, LDL-C and-TC levels and increase in HDL-C levels after the treatment was statistically significant (p

📌 3 Key Takeaways

🎯
Objective & Hypothesis:43 healthy postmenopausal patients were included to evaluate the effects of postmenopausal hormone replacement (HRT) and multivitamin therapy on serum lipoprotein-a (Lp-a) and risk factors of cardiovasculary diseases such as LDL cholesterol (LDL-C), HDL cholesterol (HDL-C), total cholesterol (TC) and triglyceride (TG) levels.
📊
Key Findings & Data:In the first group, 19 patients were given cyclic conjugated equine oestrogene (0,625 mg/day for 21 days and 5 mg/day medroxyprogesterone acetate for the last 10 days of the menstrual cycle), in the second group, 10 patients were given multivitamin therapy and the last group was the control group.
💡
Conclusion & Impact:Only in HRT group decrease in serum Lp-a, LDL-C and-TC levels and increase in HDL-C levels after the treatment was statistically significant (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

43 healthy postmenopausal patients were included to evaluate the effects of postmenopausal hormone replacement (HRT) and multivitamin therapy on serum lipoprotein-a (Lp-a) and risk factors of cardiovasculary diseases such as LDL cholesterol (LDL-C), HDL cholesterol (HDL-C), total cholesterol (TC) and triglyceride (TG) levels. In the first group, 19 patients were given cyclic conjugated equine oestrogene (0,625 mg/day for 21 days and 5 mg/day medroxyprogesterone acetate for the last 10 days of the menstrual cycle), in the second group, 10 patients were given multivitamin therapy and the last group was the control group. Serum Lp-a, LDL-C, HDL-C, TC and TG levels were determined initially and 6 months after the beginning of the therapy. The mean baseline Lp-a levels of HRT group, multivitamin group and control group were calculated as 24.9±21.7, 15.2±10.1, 23.4±21.3 respectively. After the 6th month of the therapy mean serum Lp-a levels were calculated as 20.7±18.3, 17.3±10.8, 22.9±21.2 respectively. Only in HRT group decrease in serum Lp-a, LDL-C and-TC levels and increase in HDL-C levels after the treatment was statistically significant (p

Özet

Postmenapozal hormon replasman tedavisi (HRT) ve multivitamin tedavisinin, majör kardiyovasküler hastalık risk faktörleri olan; serum lipoprotein a (Lp(a)), LDL kolesterol (LDL-C), HDL kolesterol (HDL-C), total kolesterol (TC) ve trigliserid (TG) düzeyleri üzerine olan etkisini araştırmak amacıyla, 43 postmenapozal sağlıklı hastadan, 19 hastaya 21 gün siklik konjuge equin östrojen (0.625 mg/gün ve siklusun son on günü 5 mg/gün medroksiprogesteron asetat), 10 hastaya polivitamin tedavisi verildi. 14 hastada kontrol grubu olarak belirlendi. Tedavi öncesi ve altı ay süren tedavi sonrası serum Lp (a), LDL-C, HDL-C, total kolesterol ve TG düzeyleri ölçüldü. HRT, vitamin tedavisi alan ve kontrol grubundaki hastaların tedavi öncesi serum Lp(a) düzeyleri sırasıyla; 24.9±21.7, 15.2±10.1 23.4±21.3 olarak bulunmuştur. Tedavi sonrası serum Lp(a) değerleri ise sırasıyla; 20.7±18.3, 17.3±10.8, 22.9±21.2 olarak ölçülmüştür. Yalnızca HRT grubunda serum Lp(a), LDL-C ve TC düzeylerindeki düşüş, HDL-C düzeylerindeki artış anlamlı bulunmuştur (p

🔖

Cite This Article

ÖNVURAL, B., ÖNVURAL, A., ÇELİK, N., ÇELİK, Ö. (2022). The effects of postmenopausal hormone replacement therapy to serum lipoprotein A levels and its relation with the coronary artery diseases. Türk Biyokimya Dergisi, Cilt: 25 - Sayı: 1, 15–20. https://ajindex.com/articles/621471

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (16)

  1. Matthew KA. Meilahn E. Kutler LH, Kelsey SF. Caggiula AW, Wing R.R. (1989) Menopause and risk factors of coronary heart disease. New Engl J Med. 321: 641
  2. Jacobs DR Jr. Mcbane IL. Bangdiwala SI, Criqui MH, Tyroler HA. (1990) High density lipoprotein cholesterol as a predictor of cardovasculer disease mortality in men and women; the follow-up study of the Lipid Research Clinics Prevalence Study. Am J Epidemiol 131:32
  3. Campos M, McNamara JR, Wilson PW, Ordovas JM, Schaefer EJ.(1988) Differences in low density lipoprotein subfractions and apolipoproteius in premenopausal and postmenopausal women,J Clin Endocrinol Metab., 67:30
  4. Wenger NK. Speroff L (1993) Cardiovascular health and disease in vomen. New Engl J Med., 329: 247
  5. Nasr A. Breckwoldt M. (1998) Estrogen replacement therapy and cardiovascular protection: lipid mechanisms are the tip of an iceberg. Gynecol Endocrinol., 12(1):43-59
  6. Jay M. Sullivan, MD, Memphis. Tennessee. (1996) Estrogen Replacement Therapy. Am J Med., 101(suppl 4A):56S-60S
  7. Martin KA, Freeman MW. (1993) Postmenopausal hormone replacement therapy (Editorial). N Engl J Med., 328:1115-7
  8. Kushwaha RS. (1992) Female sex steroid hormones and lipoprotein metabolism. Curr Opin Lipidol., 3:167-72
  9. Knopp RH. (1989) The effccts of oral contraceptives and postmenopausal estrogens on lipoprotein pbysiology and atherosclerosis. İn. Halbe HW. Rekers H. eds. Oral contraception into the 1990s. New York: Parthenon. 31 -45
  10. Knopp RH. (1990) Efecct of sex steroid hormones on lipoprotein levels in pre and post menopausal women. Can J Cardiol 6(suppl B):31B-5B
  11. Stampfer MJ, Colditz GA, Willett WC. et al. (1991} Postmenopausal estrogen therapy and cardiovascular disease: ten-year follow-up from the Nurses Health Study. N Engl J Med., 325:756-62
  12. Howard GC, Pizzo SV. (1993) Biology of disease:lipoprotein(a) and its role in atherothrombotic disease. Lab İnvest., 69:373-86
  13. Henriksson P, Angelin B. Berglund L. (1991) Hormonal effects on serum Lp(a) levels: marked reduciton during estrogen treatment in males with prostatic cancer (abstract). Arterioscler Thromb., 11:1423a
  14. Scanu AM. Gunter MF. (1990) Lipoprotein(a). J Clin İnvest.,85:1709-15
  15. Rymer J,Crrok D, Sidhu M, Chapman M, Stevenson JC. (1993) Effccts of tibolone on serum concentrations of lipoprotein(a) in postmenopausal women. Acta Endocrinol ( Copenh). 128:259-62
  16. Jones PH, Gotto AM Jr, Pownall HJ. Et al. (1991) Effet of gemfibrozil on plnsma lipo