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Journals / Türk Biyokimya Dergisi / 2007 / Cilt: 32 - Sayı: 2

Discovery of Ghrelin hormone: Research and clinical applications

Grelin hormonunun keşfi: Araştırmaları ve klinik uygulamaları

Süleyman AYDIN
Pages
76–89
Publication Date
2022-11-05
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In this review, it will be focused on the recent knowledge of ghrelin structure, history, function, distribution, alteration in diseases, and its possible clinical applications.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Ghrelin, orexigenic hormone, is a recently discovered, growth hormone-releasing and feeding-stimulating peptide in human and animals.
📊
Key Findings & Data:It was mainly produced in the stomach and also secreted from many other tissues (including parenchyma cell of plants), This hormone circulates in high levels in the bloodstream under fasting conditions and decreases with feeding.
💡
Conclusion & Impact:In this review, it will be focused on the recent knowledge of ghrelin structure, history, function, distribution, alteration in diseases, and its possible clinical applications.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Ghrelin, orexigenic hormone, is a recently discovered, growth hormone-releasing and feeding-stimulating peptide in human and animals. It was mainly produced in the stomach and also secreted from many other tissues (including parenchyma cell of plants), This hormone circulates in high levels in the bloodstream under fasting conditions and decreases with feeding. Ghrelin initiates meal, regulates appetite, energy expenditure and fuel utilization. In this review, it will be focused on the recent knowledge of ghrelin structure, history, function, distribution, alteration in diseases, and its possible clinical applications.

Özet

Son zamanlarda keşfedilen oreksijenik hormon olarak da bilinen grelin; insan ve hayvanlarda beslenmeyi stimule eder ve büyüme hormonu salgılatır. Bitkilerin parankima hücreleri de dahil olmak üzere diğer pek çok dokudan sagılanan grelinin asıl üretimi midede olmaktadır. Açlık halinde kanda yüksek miktarlarda bulunmakta olup, yemek yeme ile miktarı azalmaktadır. Grelin; yemek yemeyi, besin kullanımını, enerji kullanımını ve iştahı düzenlemektedir. Bu derlemede grelin hakkındaki son bilgiler, grelinin yapısı, tarihçesi, fonksiyonu, vücuttaki dağılımı, hastalıklardaki değişimine ve olası klinik uygulamalarına yoğunlaşılacaktır.

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Cite This Article

AYDIN, S. (2022). Discovery of Ghrelin hormone: Research and clinical applications. Türk Biyokimya Dergisi, Cilt: 32 - Sayı: 2, 76–89. https://ajindex.com/articles/621397

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References (16)

  1. Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K. (1999) Grelin is a growth hormone-releasing acylated peptide from stomach. Nature. 402: 656-659
  2. Korbonits M, Goldstone AP, Gueorguiev M, Grossman AB. (2004) Grelin-a hormone with multiple functions. Front in Neuroend. 25: 27-68
  3. Kojima M, Kangawa K. (2005) Grelin: structure and function. Physiol Rev. 85: 495-522
  4. Aydin S, Ozkan Y, Caylak E, Aydin S. (2006) Grelin and its biochemical functions. Turkiye Klinikleri. J Med Sci. 26: 272-283
  5. Aydin S, Aydin S, Ozkan Y, Kumru S. (2006) Grelin is present in human colostrum, transitional and mature milk. Peptides. 27: 878-882
  6. Kierson JA, Dimatteo DM, Locke RG, Mackley AB, Spear ML. (2006) Grelin and cholecystokinin in term and preterm human breast milk. Acta Paediatr. 95: 991-995
  7. Aydin S, Ozercan İH, Dagli F, Aydin S, Kumru S, Kilic N, Sahin İ, Ozercan MR. (2007) Grelin is present in human teeth. J Biochem Mol Biol. (accepted)
  8. Gnanapavan S, Kola B, Bustin SA, Morris DG, McGee P, Fairclough P, Bhattacharya S, Carpenter R, Grossman AB, Korbonits M. (2002) The tissue distribution of the mRNA of grelin and subtypes of its receptor, GHS-R, in humans. Clin Endocrinol Metab. 87: 2988-2991
  9. Wren AM, Seal LJ, Cohen MA, Brynes AE, Frost GS, Murphy KG, Dhillo WS, Ghatei MA, Bloom SR. (2001) Grelin enhances appetite and increases food intake in humans. J Clin Endocrinol Metab. 86 (12): 5992
  10. Aydin S. (2006) Proposal for the abbreviation of grelin--the appetite hormone. Horm Res. 66 (4): 206
  11. Groschl M, Uhr M, Kraus T. (2004) Evaluation of the comparability of commercial grelin assays. Clin Chem. 50 (2): 457-458
  12. Kaiya H, Darras VM, Kangawa K. (2007) Grelin in Birds: Its structure, distribution and function. The Journal of Poultry Science. 44 (1): 18
  13. Davis JC. (1954) The relation between the pancreatic alpha cells and certain cells in the gastric mucosa. J Pathol Bacteriol. 67 (1): 237-240
  14. Bowers CY, Momany F, Reynolds GA, Chang D, Hong A, Chang K. (1980) Structure-activity relationships of a synthetic pentapeptide that specifically releases growth hormone in vitro. Endocrinology. 106 (3): 663-667
  15. Bowers CY, Momany FA, Reynolds GA, Hong A. (1984) On the in vitro and in vivo activity of a new synthetic hexapeptide that acts on the pituitary to specifically release growth hormone. Endocrinology. 114 (5): 1537-1545
  16. Smith RG, Cheng K, Schoen WR, Pong SS, Hickey G, Jacks T, Butler B, Chan WW, Ch