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Journals / Türk Biyokimya Dergisi / 2014 / Cilt: 39 - Sayı: 3

Possible effects of lycopene and silymarin on rat liver functions and oxidative stress markers

[Likopen ve silimarinin sıçan karaciğer işlevleri ve oksidatif stres göstergeleri üzerine olası etkileri]

Gözde GİRGİN
Terken BAYDAR
Aysun Kılıç SÜLOĞLU
Güldeniz SELMANOĞLU
Serdar BALCI
Pages
344–350
Publication Date
2022-11-05
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Therefore, both of the lycopene and silymarin need to be investigated in detail for their possible beneficial and harmful effects

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: To evaluate effects of lycopene and silymarin on antioxidant enzymes, lipid peroxidation and possible liver toxicity in rats.Methods: 15 female Wistar rats were divided into 3 groups: control group (Group I) received corn oil while Groups II and III were treated with 100 mg/kg oral dose of lycopene and silymarin for 7 days, respectively.
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Key Findings & Data:Besides, histopathological evaluations were performed in liver.Results: Silymarin treatment resulted in significant decreases in catalase and cholesterol and increase in superoxide dismutase activities compared to control, while lycopene caused significant decrease in urea levels.
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Conclusion & Impact:Therefore, both of the lycopene and silymarin need to be investigated in detail for their possible beneficial and harmful effects
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: To evaluate effects of lycopene and silymarin on antioxidant enzymes, lipid peroxidation and possible liver toxicity in rats.Methods: 15 female Wistar rats were divided into 3 groups: control group (Group I) received corn oil while Groups II and III were treated with 100 mg/kg oral dose of lycopene and silymarin for 7 days, respectively. The antioxidant enzyme activities of liver (superoxide dismutase and catalase) and malondialdehyde level were measured. Serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP), cholesterol and urea levels were also analyzed. Besides, histopathological evaluations were performed in liver.Results: Silymarin treatment resulted in significant decreases in catalase and cholesterol and increase in superoxide dismutase activities compared to control, while lycopene caused significant decrease in urea levels. Both of the antioxidants caused an increase in liver function enzymes AST and ALT compared to the control group. In lycopene treated group, ALP levels were also increased in comparison with control. There were significant differences in cholesterol, AST and ALP levels between silymarin and lycopene treatment groups. In histopathological examinations minimal changes were observed in liver tissues.Conclusion: Lycopene and silymarin treatment may cause alterations in liver functions due to the dose and/or duration. Therefore, both of the lycopene and silymarin need to be investigated in detail for their possible beneficial and harmful effects

Özet

Amaç: Likopen ve silimarinin antioksidan enzimler ve lipid peroksidasyon üzerine etkileri ile olası karaciğer toksisitesinin sıçanlarda araştırılması.Metod: 15 dişi Wistar sıçan 3 guba ayrılmıştır: kontrol grubuna (Grup I) mısır yağı, Grup II ve Grup III'e sırasıyla 100 mg/kg likopen veya silimarin oral yolla 7 gün boyunca verilmiştir. Karaciğerdeki antioksidan enzim aktiviteleri (süperoksit dismutaz ve katalaz) ve malondialdehit seviyesi ölçülmüştür. Serumda ise alanine aminotransferaz (ALT), aspartate aminotransferaz (AST), alkalin fosfataz (ALP) aktiviteleri; kolesterol ve üre düzeyleri ölçülmüştür. Ayrıca, karaciğer histopatolojik açıdan değerlendirilmiştir.Bulgular: Silimarin grubunda kontrol grubuna göre, katalaz ve kolesterolde istatistiksel olarak önemli bir azalma görülürken, süperoksit dismutaz aktivitesinde artış olmuştur. Likopen grubu kontrol grubuyla karşılaştırıldığında üre düzeyi önemli derecede azalmıştır. Karaciğer işlevini gösteren AST ve ALT enzimleri her iki grupta da kontrol grubuna kıyasla artmıştır. Likopen uygulama grubunda ALP aktivitesi de önemli dercede artmıştır. Ayrıca kolesterol düzeyleri, AST ve ALT aktivitesi silimarin ve likopen grupları arasında farklılık göstermiştir. Histopatolojik incelemelerde minimal değişiklikler gözlenmiştir. Sonuç: Likopen ve silimarin kullanımı doz ve/veya süreye bağlı olarak karaciğer işlevleri üzerinde değişikliklere yol açabilir. Bu nedenle likopen ve silimarinin olası yararlı ve zararlı etkilerinin ayrıntılı olarak araştırılmasına gereksinim bulunmaktadır

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Cite This Article

GİRGİN, G., BAYDAR, T., SÜLOĞLU, A. K., SELMANOĞLU, G., BALCI, S. (2022). Possible effects of lycopene and silymarin on rat liver functions and oxidative stress markers. Türk Biyokimya Dergisi, Cilt: 39 - Sayı: 3, 344–350. https://ajindex.com/articles/621379

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