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Journals / Türk Biyokimya Dergisi / 2009 / Cilt: 34 - Sayı: 3

MCP-1 -2518 G ve rantes -403 A allelleri periodontitis için bir risk faktörü müdür?

Are monocyte chemoattractant protein-1-2518 G and regulated activation normal T Cell expressed and secreted -403 A alleles risk factor for periodontitis?

Özgün ÖZÇAKA
Nurgün BIÇAKÇI
Timur KÖSE
Afig BERDELİ
Pages
139–147
Publication Date
2022-11-05
DOI
—
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

Significant improvements in clinical parameterswere found after periodontal therapy in both genotypes (P

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: We aimed to analyze the monocyte chemoattractant protein-1 (MCP-1) and regulated on activation, normal T cell expressed and secreted (RANTES) polymorphisms inrelation to susceptibility to chronic periodontitis and influence of genotypes in response tonon-surgical periodontal therapy.
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Key Findings & Data:Methods: This cross-sectional clinical study was performed during 2005-2006 in Turkey.Gene polymorphisms were investigated in 51 periodontitis patients and 48 periodontallyhealthy subjects.
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Conclusion & Impact:Significant improvements in clinical parameterswere found after periodontal therapy in both genotypes (P
🔬Design:Research Article
📍Scope:2005-2006 Verileri
⚙️Variables:Domain Parameters

Abstract

Objective: We aimed to analyze the monocyte chemoattractant protein-1 (MCP-1) and regulated on activation, normal T cell expressed and secreted (RANTES) polymorphisms inrelation to susceptibility to chronic periodontitis and influence of genotypes in response tonon-surgical periodontal therapy. Methods: This cross-sectional clinical study was performed during 2005-2006 in Turkey.Gene polymorphisms were investigated in 51 periodontitis patients and 48 periodontallyhealthy subjects. Quadrant scaling and root planning was performed to periodontitis patients.Genomic DNA was analyzed for polymorphisms by polymerase chain reaction amplificationfollowed by restriction enzyme digestion. Results: Genotype distributions of related genes were similar between periodontitis andhealthy subjects (P>0.05). In periodontitis group, monocyte chemoattractant protein-1-2518G allele frequencies were 25.5%, regulated on activation, normal T cell expressed andsecreted-403A allele frequencies were 30.4%. Percentage of bleeding sites were significantlyhigher in regulated on activation, normal T cell expressed and secreted gene A negative genotypes compared to A positive (P=0.023). Significant improvements in clinical parameterswere found after periodontal therapy in both genotypes (P

Özet

Amaç: Bu çalışmada, “monocyte chemoattractant protein-1” (MCP-1) ve “regulated on activation, normal T cell expressed and secreted” (RANTES) gen polimorfizmlerinin kronikperiodontitise yatkınlık ile olan ilişkileri ve uygulanan cerrahisiz periodontal tedaviye yanıtagenotiplerin etkisini araştırmayı amaçladık. Yöntem: Bu kesitsel klinik çalışma 2005-2006 döneminde Türkiye’de gerçekleştirildi. Genpolimorfizmleri 51 periodontitisli ve 48 periodontal sağlıklı bireyde incelendi. Periodontitisli hastaların her yarım çenesine diş yüzeyi temizliği ve kök yüzeyi düzleştirmesi işlemleriyapıldı. Genomik DNA polimeraz zincir reaksiyonu amplifikasyonu sonrası restriksiyonenzim dijesyonu ile -403G/A ve -2518A/G polimorfizmlerinin analizleri yapıldı. Bulgular: Periodontitisli ve sağlıklı bireylerde her iki genin de genotip dağılımları benzerdir(P>0.05). Kronik periodontitis grubunun -2518G allel frekansı 25.5%, -403A allel frekansı30.4% dür. Sondalamada kanamalı bölgelerin oranı „regulated on activation, normal T cellexpressed and secreted” geninde A negative genotiplerde, A pozitif genotiplere göre anlamlıolarak yüksektir (P=0.023). Her iki genin genotiplerinde cerrahisiz periodontal tedavisonrasında klinik parametrelerde anlamlı düzelmeler bulunmuştur (P

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Cite This Article

ÖZÇAKA, Ö., BIÇAKÇI, N., KÖSE, T., BERDELİ, A. (2022). MCP-1 -2518 G ve rantes -403 A allelleri periodontitis için bir risk faktörü müdür?. Türk Biyokimya Dergisi, Cilt: 34 - Sayı: 3, 139–147. https://ajindex.com/articles/621326

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References (17)

  1. Beck JD, Slade GD. (1996) Epidemiology of periodontal diseases. Cur Op Periodon 3: 3-9
  2. Kinane DF, Hart TC. (2003) Gene and gene polymorphisms associated with periodontal disease. Critical Rev Oral Biol Med 14: 430–49
  3. Takashiba S, Naruishi K. (2006) Gene polymorphisms in periodontal health and disease. Periodontol 2000 40: 94–106
  4. Graves DT. (1999) The potential role of chemokines and inflammatory cytokines in periodontal disease progression. Clin Infect Dis 28: 482–90
  5. Nelson PJ, Krensky AM. (2001) Chemokines, chemokine receptors, and allograft rejection. Immunity 14: 377-86 [6] Rossi D, Zlotnik A. (2000) The biology of chemokines and their receptors. Ann Rev Immunol 18: 217–42
  6. Baggiolini M. (2001) Chemokines in pathology and medicine. J Intern Med 250: 91–104
  7. Garlet GP, Martins WJr, Ferreira BR, Milanezi CM, Silva JS. (2003) Patterns of chemokines and chemokine receptors expression in different forms of human periodontal disease. J Periodontal Res 38:210-17
  8. Rollins BJ. (1996) Monocyte chemoattractant protein 1: a potent regulator of monocyte recruitment in inflammatory disease. Mol Med Today 25:198–204
  9. Zlotnik A, Yoshie O. (2000) Chemokines: A new classification system and their role in immunity. Immunity 12: 121-27
  10. Luster AD. (1998) Chemokines-chemotactic cytokines that mediate inflammation. New Engl J Med 338:436-45
  11. Gerard C, Rollins BJ. (2001) Chemokines and disease. Nat Immun 2: 108-15
  12. Emingil G, Atilla G, Hüseyinov A. (2004) Gingival crevicular fluid monocyte chemoattractant protein-1 and RANTES levels in patients with generalized aggressive periodontitis. J Clin Periodontol 31: 829–34
  13. Liu H, Chao D, Nakayama EE, Taguchi H, Goto M, Xin X, et al. (1999) Polymorphism in RANTES chemokine promoter affects HIV-1 disease progression. P Natl Acad Sci 96: 4581-585
  14. Rovin BH, Lu L, Saxena R. (1999) A novel polymorphism in the MCP-1 gene regulatory region that influences MCP-1 expression. Biochem Bioph Res Co 259: 344-48
  15. Szalai C, Kozma GT, Nagy A, Bojszkó A, Krikovszky D, Szabó T,et al. (2001) Polymorphism in the gene regulatory region of MCP-1 is associated with asthma susceptibility and severity. J Allergy Clin Immun 108: 375-81
  16. Kinane DF, Shiba H, Hart TC. (2005) The genetic basis of periodontitis. Periodontol 2000 39: 91–117
  17. Loos BG, John RP, Laine ML. (2005) Identification of genetic risk factors for periodontitis and possible mechanisms of action. J Clin Periodont