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Journals / Türk Biyokimya Dergisi / 2017 / Cilt: 42 - Sayı: 1

NT-proBNP levels in β-thalassemia major patients without cardiac hemosiderosis

Kardiyak Hemosiderozis Bulunmayan β-Talasemi Major Hastalarında NT-proBNP Düzeyleri

Erdal KURTOĞLU
Volkan KARAKUŞ
Ayşegül Uğur KURTOĞLU
Selen BOZKURT
Pages
71–75
Publication Date
2022-11-05
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Detection of highNT-proBNP levels above cut-off values in patients whose T2* values are normal indicates that measurement of NTpro-BNP is a more sensitive marker in early detection of cardiac failure.

📌 3 Key Takeaways

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Objective & Hypothesis:Introduction: Heart failure due to hemosiderosis is frequent in beta-thalassemia major (β-TM) patients.
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Key Findings & Data:In this study, we aimed to investigate the efficacy of NT-proBNP levels in thalassemia patients, who are thought to have no cardiac iron deposition according to T2* scoring system (CMRT2* > 20 msn), in early identification of cardiac failure.Methods: NT-proBNP levels of 31 patients, who have T2* > 20 ms, and of 25 healthy population were measured by chemoluminescence method.Results: NT-proBNP levels were not different in thalassemic patients [median: 33 (IQR: 28–94) pg/mL] compared to control group [median: 41 (IQR: 28–59) pg/mL].
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Conclusion & Impact:Detection of highNT-proBNP levels above cut-off values in patients whose T2* values are normal indicates that measurement of NTpro-BNP is a more sensitive marker in early detection of cardiac failure.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Introduction: Heart failure due to hemosiderosis is frequent in beta-thalassemia major (β-TM) patients. Magnetic resonance imaging (MRI) is used in the early detection of heart failure. Amino-terminal pro-brain natriuretic peptide (NT-proBNP) is a very sensitive marker in the diagnosis of heart failure. In this study, we aimed to investigate the efficacy of NT-proBNP levels in thalassemia patients, who are thought to have no cardiac iron deposition according to T2* scoring system (CMRT2* > 20 msn), in early identification of cardiac failure.Methods: NT-proBNP levels of 31 patients, who have T2* > 20 ms, and of 25 healthy population were measured by chemoluminescence method.Results: NT-proBNP levels were not different in thalassemic patients [median: 33 (IQR: 28–94) pg/mL] compared to control group [median: 41 (IQR: 28–59) pg/mL]. We found that NT-proBNP level was above cut-off value in six patients.Conclusion: NT-proBNP is a cheaper, reachable, and noninvasive method compared to MRI technique, it can be easily used in monthly controls. Detection of highNT-proBNP levels above cut-off values in patients whose T2* values are normal indicates that measurement of NTpro-BNP is a more sensitive marker in early detection of cardiac failure.

Özet

Giriş: Beta-talasemi major (?-TM) hastalarında hemosiderozise bağlı kalp yetmezliği sık görülmektedir. Kalp yetmezliğini erken dönemde tespit etmek için manyetik rezonans görüntüleme (MRI) yöntemi kullanılmaktadır. N-terminal beyin natriüretik peptid (NT-proBNP) kalp yetmezliğinin tanısında oldukça hassas bir belirteçtir. Bu çalışmamızda T2* skoruna göre kardiyak demir birikimi olmayan (CMRT2* > 20 msn) ?-TM hastalarında, kalp yetmezliğinin erken dönemde tanısında NT-proBNP'nin etkinliğini araştırdık.Yöntem: T2* > 20 ms olan 31 ?-TM hastası ve 25 sağlıklı kişide NT-ProBNP düzeyleri kemilüminesans yöntem ile ölçüldü.Bulgular: Hastaların NT-proBNP düzeyleri [ortanca: 33 (IQR: 28-94) pg/mL] ile kontrol grubu [ortanca: 41 (IQR: 28-59) pg/mL] arasında anlamlı bir fark tespit edilmedi. Hastaların 6'sında NT-proBNP düzeylerinin cut-off değerinin üzerinde olduğu belirlendi.Sonuç: MRI yöntemi ile kıyaslandığında NT-proBNP daha ucuz, ulaşılabilir ve girişimsel olmayan bir yöntemdir. Talasemi hastalarının aylık kontrollerinde dahi kolaylıkla uygulanabilir. T2* skoru normal olan hastaların bazılarında NT-proBNP düzeylerinin cut-off değerlerinden daha yüksek bulunması, NT-proBNP'nin kalp yetmezliğini erken dönemde tespit etmede daha hassas bir belirteç olduğunu göstermektedir

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Cite This Article

KURTOĞLU, E., KARAKUŞ, V., KURTOĞLU, A. U., BOZKURT, S. (2022). NT-proBNP levels in β-thalassemia major patients without cardiac hemosiderosis. Türk Biyokimya Dergisi, Cilt: 42 - Sayı: 1, 71–75. https://ajindex.com/articles/621308

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