The Relationship Between Glycemic Control And Asymmetrical Dimethylarginine Levels

In multiple lineer regression analyses mHbA1c, glucose and duration of diabetes ( R²=0,343, p=0,000) or cHbA1c, glucose and duration of diabetes (R²=0,318 p

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: The relationship of asymmetrical dimethylarginine (ADMA) and glycemic control in diabetes is not yet fully enlightened.

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Key Findings & Data:We aim to investigate the association of ADMA and hemoglobin A1c (HbA1c) in normal glomerular filtration rate (GFR) diabetic patients.Methods: This cross sectional study included 88 diabetic patients whose GFRs were in reference range. 2 different HbA1c values; current (cHbA1c) and mean of 4 successive measurements with 3 months intervals (mHbA1c) were used.

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Conclusion & Impact:In multiple lineer regression analyses mHbA1c, glucose and duration of diabetes ( R²=0,343, p=0,000) or cHbA1c, glucose and duration of diabetes (R²=0,318 p

🔬Design:Research Article

📍Scope:Comprehensive Sample

⚙️Variables:Domain Parameters

Abstract

Objective: The relationship of asymmetrical dimethylarginine (ADMA) and glycemic control in diabetes is not yet fully enlightened. We aim to investigate the association of ADMA and hemoglobin A1c (HbA1c) in normal glomerular filtration rate (GFR) diabetic patients.Methods: This cross sectional study included 88 diabetic patients whose GFRs were in reference range. 2 different HbA1c values; current (cHbA1c) and mean of 4 successive measurements with 3 months intervals (mHbA1c) were used. The association of ADMA with HbA1c levels and other clinical characteristics of patients were evaluated.Results: We found significant inverse correlations between ADMA and both current (r =-0,354, p=0,001) and mean HbA1c(r=-0,377, p=0,000) levels. In multiple lineer regression analyses mHbA1c, glucose and duration of diabetes ( R²=0,343, p=0,000) or cHbA1c, glucose and duration of diabetes (R²=0,318 p

Özet

Amaç: Asimetrik Dimetilarginin (ADMA)'nın diyabet ve glisemik kontrolle ilişkisi henüz aydınlatılamamıştır. Çalışmamızda normal glomeruler filtrasyonu(GFR) olan farklı glisemik kontroldeki hastalarda hemoglobin A1c (HbA1c) düzeyi ile ADMA ilişkisini inceledik.Yöntemler: Bu kesitsel çalışmaya normal GFR'li 88 diyabetik hasta dahil edildi. 2 farklı HbA1c düzeyi; son HbA1c ve 3 ay aralıklarla ölçülen 4 HbA1c ortalamasını içeren ortalama (ort HbA1c)düzeyleri kullanıldı. ADMA'nın HbA1c düzeyleri ve hastaların diğer klinik durumları ile olan ilişkisi değerlendirildi.Bulgular: ADMA ile ort HbA1c ve son HbA1c düzeyleri arasında negatif yönlü zayıf bir ilişki saptandı (ortHbA1c r=-0.377,p=0.000) (son HbA1c; r=-0.354,p=0.001) Multiple Lineer Regresyon Analizinde ortHbA1c,glukoz ve diyabet süresi (R²=0.343, p=0.000) ile son HbA1c,glukoz ve diyabet süresinin (R²=0.318 p

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Cite This Article

YÜCEL, N., ARIKAN, Z., KAPTANAĞASI, A. O., MADENCİ, Ö. Ç., AKBABA, D., KAYA, O., SARGIN, M. (2022). The Relationship Between Glycemic Control And Asymmetrical Dimethylarginine Levels. Türk Biyokimya Dergisi, Cilt: 38 - Sayı: 3, 286–290. https://ajindex.com/articles/621256

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