Journals / Türk Biyokimya Dergisi / 2014 / Cilt: 39 - Sayı: 4

A very rare complication of carbon monoxide intoxication; thrombotic thrombocytopenic purpura

[Karbonmonoksit zehirlenmesinde nadir bir komplikasyon: Trombotik trombositopenik purpura]

Pages
571–573
Publication Date
2022-11-05
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Thrombotic thrombocytopenic purpura which might have complication should be kept in mind in patients with carbon monoxide intoxication

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Carbon monoxide intoxication is an important public health problem, which may result in death.
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Key Findings & Data:A 46-year-old male patient was found in an unconscious state at home and was transported to the emergency service by the patient’s relatives.
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Conclusion & Impact:Thrombotic thrombocytopenic purpura which might have complication should be kept in mind in patients with carbon monoxide intoxication
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Carbon monoxide intoxication is an important public health problem, which may result in death. A 46-year-old male patient was found in an unconscious state at home and was transported to the emergency service by the patient’s relatives. Relatives of the patients were indicated that there was gas leak from the stove. At first it was considered that the patient might be poisoned with carbon monoxide. The laboratory findings were, creatinine 2.5 mg/ dL and creatinine kinase 88.15 U/L. Carboxy hemoglobin level was 30.9%. Hyperbaric oxygen therapy was commenced with the diagnosis of carbon monoxide intoxication. The laboratory values in the 2nd day of admission were, creatinine 5.8 mg/ dL, creatinine kinase 88.42 U/L. Then the patient underwent a hemodialysis. Hemoglobin levels decreased to 7.3 g/dL, platelet count dropped to 11.000/mm3. Peripheral blood smear showed erythrocyte fragmentation. Thrombotic thrombocytopenic purpura was considered and methylprednisolone and plasmapheresis was started. After the 10th session of plasmapheresis, platelet value was over 150.000/mm3 and plasmapheresis was discontinued. Platelet value was 285.000/mm3 and creatinine 0.7 mg/dL. The patient was discharged. Thrombotic thrombocytopenic purpura which might have complication should be kept in mind in patients with carbon monoxide intoxication

Özet

Karbonmonoksid zehirlenmesi ölümle sonuçlanabilen önemli bir halk sağlığı sorunudur. Evinde bilinç kaybı gelişmiş bir şekilde bulunan 46 yaşında erkek hasta acil servise getirildi. Hasta yakınları hastayı evde bulduklarında sobadan gaz sızıntısı olduğunu ifade ettiler. Bunun üzerine hastada karbonmonoksid zehirlenmesi gelişmiş olabileceği düşünüldü. Hastanın yapılan laboratuvar testlerinde kreatinin 2,5 mg/dL, kreatin kinaz 88.15 U/L olarak bulundu. Karboksihemoglobin düzeyi %30.9 idi. Hastaya CO zehirlenmesine yönelik hiperbarik oksijen tedavisi başlandı. Yatışının 2. gününde kreatinin 5.8 mg/dL, kreatin kinaz 88.42 U/L olarak bulundu. Hasta hemodiyaliz tedavisine alındı. Hastanın hemoglobin düzeyi 7.3 g/dL'e, trombosit sayısı 11.000/mm3'e düştü. Yapılan periferik yaymada parçalanmış eritrositlerin olduğu görüldü. Hastada trombotik trombositopenik purpura gelişmiş olabileceği düşünülerek metilprednizolon ve plazmaferez tedavisine başlandı. 10 seans plazmaferez tedavisinden sonra hastanın trombosit değeri 150.000/mm3 üzerinde seyrettiği görülerek plazmaferez tedavisi sonlandırıldı. Hastanın trombosit değerinin 285.000/mm3, kreatinin düzeyinin 0.7 mg/dL olması üzerine hasta taburcu edildi. Trombotik trombositopenik purpura, karbon monoksit zehirlenmesi olan hastalarda bir komplikasyon olarak akılda tutulmalıdır

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Cite This Article

DOĞAN, H. O., OĞUZ, E. G., ÖZKAYAR, N., TURHAN, T., BULUT, M., DEDE, F., PİŞKİNPAŞA, S. (2022). A very rare complication of carbon monoxide intoxication; thrombotic thrombocytopenic purpura. Türk Biyokimya Dergisi, Cilt: 39 - Sayı: 4, 571–573. https://ajindex.com/articles/621228

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