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Journals / Türk Biyokimya Dergisi / 2014 / Cilt: 39 - Sayı: 4

The effects of dexmedetomidine on oxidant - antioxidant systems in the experimental model of carbondioxide pneumoperitoneum

[Deneysel karbondioksit pnömoperitonyum modelinde deksmedetomidin'in oksidan-antioksidan sistem üzerine etkisinin araştırılması]

Özgür YAĞAN
Tülin BAYRAK
Nilay TAŞ
Ahmet BAYRAK
Tevfik NOYAN
Sema Nur AYYILDIZ
Murat KARAKAHYA
Burcu ÜSTÜN
Sevil IŞIK
Pages
488–494
Publication Date
2022-11-05
DOI
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The rats were rested 30 minutes after desufflation and blood samples were obtained for; ischaemia modified albumin (IMA), myeloperoxidase (MPO), advanced oxidation protein products (AOPP), catalase (CAT), paraoxonase (PON1) and platelet-activating factor acetylhydrolase (PAF-AH) analyses.Results: When compared with the control group; the serum IMA levels significantly decreased in group II, and also increased in group III as compared to control (p

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Objective & Hypothesis:Objective: The aim of the study was to investigate the changes of oxidative and anti-oxidative systems in the splanchnic area during carbon dioxide pneumoperitoneum and to determine whether the administration of dexmedetomidine has effects on these systems.Methods: Forty rats were randomized into four groups: Group I; Control, Group II; No pneumoperitoneum, Dexmedetomidine administration, Group III; Pneumoperitoneum, no Dexmedetomidine administration and Group IV; Pneumoperitoneum and Dexmedetomidine administration 30 minutes before insufflation.
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Key Findings & Data:Objective: The aim of the study was to investigate the changes of oxidative and anti-oxidative systems in the splanchnic area during carbon dioxide pneumoperitoneum and to determine whether the administration of dexmedetomidine has effects on these systems.Methods: Forty rats were randomized into four groups: Group I; Control, Group II; No pneumoperitoneum, Dexmedetomidine administration, Group III; Pneumoperitoneum, no Dexmedetomidine administration and Group IV; Pneumoperitoneum and Dexmedetomidine administration 30 minutes before insufflation.
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Conclusion & Impact:The rats were rested 30 minutes after desufflation and blood samples were obtained for; ischaemia modified albumin (IMA), myeloperoxidase (MPO), advanced oxidation protein products (AOPP), catalase (CAT), paraoxonase (PON1) and platelet-activating factor acetylhydrolase (PAF-AH) analyses.Results: When compared with the control group; the serum IMA levels significantly decreased in group II, and also increased in group III as compared to control (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: The aim of the study was to investigate the changes of oxidative and anti-oxidative systems in the splanchnic area during carbon dioxide pneumoperitoneum and to determine whether the administration of dexmedetomidine has effects on these systems.Methods: Forty rats were randomized into four groups: Group I; Control, Group II; No pneumoperitoneum, Dexmedetomidine administration, Group III; Pneumoperitoneum, no Dexmedetomidine administration and Group IV; Pneumoperitoneum and Dexmedetomidine administration 30 minutes before insufflation. The rats were rested 30 minutes after desufflation and blood samples were obtained for; ischaemia modified albumin (IMA), myeloperoxidase (MPO), advanced oxidation protein products (AOPP), catalase (CAT), paraoxonase (PON1) and platelet-activating factor acetylhydrolase (PAF-AH) analyses.Results: When compared with the control group; the serum IMA levels significantly decreased in group II, and also increased in group III as compared to control (p

Özet

Amaç: Bu çalışmanın amacı, karbondioksit pnömoperitonyum sırasında splanknik sahada oluşan oksidan ve antioksidan sistemlerdeki değişiklikleri ve deksmedetomidin uygulamasının bu değişiklikler üzerine etki gösterip göstermediğini tespit etmektir.Metod: Kırk adet rat randomize olarak dört gruba ayrıldı. Grup I; kontrol, Group II; pnömoperitonyum uygulanmayan sadece deksmedetomidin verilen grup, Group III; pnömoperitonyum uygulanan ancak deksmedetomidin verilmeyen grup ve Grup IV; pnömoperitonyum uygulanan ve insuflasyondan 30 dakika önce deksmedetomidin verilen grup. Desuflasyon sonrası 30 dakika dinlendirilen ratlardan; iskemi modifiye albümin (İMA), miyeloperoksidaz (MPO), ileri oksidasyon protein ürünleri (AOPP), katalaz (CAT), paroksonaz (PON1) ve trombosit aktive edici faktör asetil hidrolaz (PAF-AH) analizi için kardiyak ponksiyonla kan örnekleri alındı.Bulgular: Kontrol grubu ile karşılaştırıldığında, serum İMA seviyeleri Grup II'de azalmış Grup III'de ise artmış olarak bulundu (p

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Cite This Article

YAĞAN, Ö., BAYRAK, T., TAŞ, N., BAYRAK, A., NOYAN, T., AYYILDIZ, S. N., KARAKAHYA, M., ÜSTÜN, B., IŞIK, S. (2022). The effects of dexmedetomidine on oxidant - antioxidant systems in the experimental model of carbondioxide pneumoperitoneum. Türk Biyokimya Dergisi, Cilt: 39 - Sayı: 4, 488–494. https://ajindex.com/articles/621167

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