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Journals / Türk Biyokimya Dergisi / 2016 / Cilt: 41 - Sayı: 3

Hypoglycemic and hypolipidemic effects of Caralluma tuberculata and its safety on liver and kidneys of diabetic rats

Diyabetik sıçanların karaciğer ve böbrekleri üzerinde Caralluma tuberculata'nın hipoglisemik ve hipolipidemik etkisi ve güvenliği

Jafar POODİNEH
Alireza NAKHAEE
Pages
136–143
Publication Date
2022-11-05
DOI
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⚡ TL;DR(Too Long; Didn't Read)

The effects of 45 days of treatment with the SCT on oral glucose tolerance test (OGTT), lipid profile, hematological and biochemical parameters evaluated.Results: SCT treated groups exhibited a significant (p

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Caralluma tuberculata is a succulent plant that grows in some regions of Baluchestan province in Iran, and is widely used by natives as antidiabetic agent.
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Key Findings & Data:This study evaluates the antidiabetic effects of aerial part suspension of Caralluma tuberculata (SCT) at two doses of 100 and 200 mg/kg and its safety on liver and kidneys of Streptozotocin (STZ)-induced diabetic rats.Methods: Diabetes was rendered via single dose of STZ (60 mg/kg, injected intraperitoneally).
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Conclusion & Impact:The effects of 45 days of treatment with the SCT on oral glucose tolerance test (OGTT), lipid profile, hematological and biochemical parameters evaluated.Results: SCT treated groups exhibited a significant (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: Caralluma tuberculata is a succulent plant that grows in some regions of Baluchestan province in Iran, and is widely used by natives as antidiabetic agent. This study evaluates the antidiabetic effects of aerial part suspension of Caralluma tuberculata (SCT) at two doses of 100 and 200 mg/kg and its safety on liver and kidneys of Streptozotocin (STZ)-induced diabetic rats.Methods: Diabetes was rendered via single dose of STZ (60 mg/kg, injected intraperitoneally). Forty eight rats were classified into 6 groups as follow; (I): Normal control, (II): Normal + SCT (200 mg/kg), (III): STZ Diabetic, (IV): STZ + vehicle, (V): STZ + SCT (100 mg/kg), (VI) STZ + SCT (200 mg/kg). The effects of 45 days of treatment with the SCT on oral glucose tolerance test (OGTT), lipid profile, hematological and biochemical parameters evaluated.Results: SCT treated groups exhibited a significant (p

Özet

Amaç: Caralluma tuberculata İran'ın Beluçistan bölgesinde yetişen, lezzetli bir bitkidir ve yaygın olarak yerliler tarafından anti-diyabetik olarak kullanılmaktadır. Bu çalışmada, Caralluma tuberculata (SCT)'nın antenlerinden elde edilen suspansiyonun 100 ve 200 mg/kg lık dozlarda Streptozotocin (STZ) ile indüklenmiş diyabetik sıçanlarda kullanımı ve karaciğer ve böbrekler üzerindeki güvenliği incelenmiştir.Metod: Sıçanlarda periton içine 60mg/kg STZ verilerek diyabet oluşturulmuştur. Kırk sekiz sıçan, (I): Normal control, (II): Normal + SCT (200 mg/kg), (III): STZ Diabetic, (IV): STZ + vehicle, (V): STZ + SCT (100 mg/kg), (VI) STZ + SCT (200 mg/kg) olmak üzere altı gruba ayrılmıştır. 45 günlük SCT tedavisi sürecinde glukoz toleransı (OGTT) lipid profilleri, kan ve biyokşmyasal parametreleri değerlendirilmiştir.Bulgular: SCT ile tedavi edilen grupların, diyabetik kontrol grubuna göre, biyokimyasal ve kan parametreleri ile OGGT anomalilerinde belirgin bir (p

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Cite This Article

POODİNEH, J., NAKHAEE, A. (2022). Hypoglycemic and hypolipidemic effects of Caralluma tuberculata and its safety on liver and kidneys of diabetic rats. Türk Biyokimya Dergisi, Cilt: 41 - Sayı: 3, 136–143. https://ajindex.com/articles/621072

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