Journals / Türk Biyokimya Dergisi / 2016 / Cilt: 41 - Sayı: 1

Sentetik kannabinoid ("bonzai") kullanımına bağlı rabdomiyoliz: İki olgu sunumu

Synthetic cannabinoid ("bonsai") induced rhabdomyolysis; two case reports

Pages
51–54
Publication Date
2022-11-05
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

These two cases underline the risk of rhabdomyolysis development, apart from well-known side effects of SCs

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Synthetic cannabinoid (SC) products are called "Spice" in Europe, "K2" in the United States and "Bonsai" in Turkey and sold under the counter.
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Key Findings & Data:Laboratory investigations revealed increased urea, serum creatinine, creatinine phosphokinase, lactate dehydrogenase and transaminase levels.
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Conclusion & Impact:These two cases underline the risk of rhabdomyolysis development, apart from well-known side effects of SCs
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Synthetic cannabinoid (SC) products are called "Spice" in Europe, "K2" in the United States and "Bonsai" in Turkey and sold under the counter. Widespread uses of these substances and lack of specific regulations about them cause serious problems. It is not very clear what these psychoactive products contain and how much and how often they can be given. Their metabolic effects are not known well either. There is not much known about the effects of SCs other than the ones on the neurological and cardiovascular systems. In this report, we presented two cases of rhabdomyolysis developing after bonsai consumption and requiring dialysis. Two bonsai users have been brought to our emergency department in an unconscious state. Their physical examinations were normal except tachicardia. Laboratory investigations revealed increased urea, serum creatinine, creatinine phosphokinase, lactate dehydrogenase and transaminase levels. The histories of the cases suggested that they had rhabdomyolysis due to cannabinoid use. A single session hemodialysis was performed for both cases. Their clinical appearance reached to stabilisation in the second hospital day and blood tests were normalised in one week. The patients were discharged at the end of the week with the normal laboratory results and psyciatric recommendations. These two cases underline the risk of rhabdomyolysis development, apart from well-known side effects of SCs

Özet

Sentetik kannabinoid (SK) ürünleri Avrupa'da "Spice", ABD'de "K2", Türkiye'de ise "Bonzai" ya da "Jamaika" olarak adlandırılıp denetimsiz olarak satılmaktadır. Bu maddelerin yaygın kullanımı ve bu maddelere özgü düzenlemelerin bulunmaması ciddi bir problemdir. Dozaj ve içerik açısından yapıları tam olarak bilinmeyen psikoaktif bu ürünlerin metabolik etkileri iyi bilinmemektedir. SK'ların nörolojik ve kardiovasküler sistem etkileri dışında etkileri iyi bilinmemektedir. Biz, bonzai kullanımı sonrası gelişen diyaliz tedavisi gerektiren iki rabdomyoliz vakalarını sunduk. Bu yazıda, bilinç bulanıklığı nedeni ile acil servisimize getirilen bonsai kullanıcısı iki vakayı sunmaktayız. Fizik muayeneleri taşikardi haricinde normaldi. Labaratuar inclemeleri serumda üre, kreatinin, kreatinin fosfokinaz, laktat dehidrogenaz ve transaminaz düzeylerinin artışını gösteriyordu. Vakalarda hasta hikayelerine dayanılarak kannabiod kullanimına bağlı rabdomyoliz düşünüldü. Her iki hasta için de tek seans hemodiyaliz uygulandı. Hastaların klinik durumunda stabilizasyon hastaneye yatışın ikinci gününde, labaratuar testlerinde normalizasyon ise bir hafta içinde sağlandı. Bir haftanın sonunda normal labaratuar sonuçları ve ayaktan psikiyatri izlemi ile taburcu edildiler. Bu iki vaka, SK'lerin bilinen yan etkilerinin yanında, rabdomyoliz gelişim riskini vurgulamaktadır

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Cite This Article

OĞUZ, E. G., CANBAKAN, B., OKYAY, G. U., BULUT, C., AYLI, D. (2022). Sentetik kannabinoid ("bonzai") kullanımına bağlı rabdomiyoliz: İki olgu sunumu. Türk Biyokimya Dergisi, Cilt: 41 - Sayı: 1, 51–54. https://ajindex.com/articles/621065

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