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Journals / Türk Biyokimya Dergisi / 2016 / Cilt: 41 - Sayı: 4

Mide kanserinde leptin ve reseptörlerinin (ObR, sObR) ekspresyonları arasındaki korelasyon

Correlation between the expressions of leptin and its receptors (ObR,sObR) in gastric cancer

Asuman SAVAŞCIHABEŞ
Eser KILIÇ
Nuri ÇAKIR
Banu Demet ÖZEL COŞKUN
Işıl ÇAKIR
Pages
243–249
Publication Date
2022-11-05
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Thus,leptin and ObR may be important indicatorsin GC.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: The expressions of leptin and itsreceptor (ObR) have been observed in human gastriccancer (GC) tissue.
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Key Findings & Data:This study aimedto evaluate the relationship between leptin, gastric ObRprotein and soluble leptin receptor (sObR) levels andwhether their possible role of indicator in GC.Methods: Serum leptin, gastric leptin and serum sObR concentrationswere determined in 30 male patients with GCand 25 male dyspeptic subjects by enzyme linked immunosorbentassay.
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Conclusion & Impact:Thus,leptin and ObR may be important indicatorsin GC.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: The expressions of leptin and itsreceptor (ObR) have been observed in human gastriccancer (GC) tissue. Leptin can promote the proliferationof GC cells. However, the correlation between leptin andObR expressions in GC and the role of gastric ObR proteinlevels in patients with GC is still unclear. This study aimedto evaluate the relationship between leptin, gastric ObRprotein and soluble leptin receptor (sObR) levels andwhether their possible role of indicator in GC.Methods: Serum leptin, gastric leptin and serum sObR concentrationswere determined in 30 male patients with GCand 25 male dyspeptic subjects by enzyme linked immunosorbentassay. We analysed the expression of gastricObR levels in endoscopically obtained biopsy samples byusing Western Blotting method.Results: Compared with controls, patients had lowerserum leptin and higher gastric tissue leptin levels. sObRprotein concentrations of patients were detected significantlyhigher, gastric ObR protein expression were lowerthan subjects in control group.Conclusion: Leptin in gastric cancerous region and sObRin circulation are overexpressed in GC. Their expressionsare associated with malignancy. Decreased leptin levels,induces the sObR signal in circulation. This negative feedbackregulation is also seen in gastric tissue: increasedgastric tissue leptin levels inhibits gastric ObR proteinexpression. Thus,leptin and ObR may be important indicatorsin GC.

Özet

Amaç: Leptin ve reseptörünün (ObR) ekspresyonu, insan mide kanseri (GC) dokusunda gözlenmiştir. Leptin GC hücrelerinin çoğalmasını teşvik edebilir. Ancak, GC olan hastalarda leptin ve ObR ekspresyonu ile mide ObR protein düzeylerinin rolü arasındaki ilişki hala net değildir. Bu çalışma GC'de leptin, mide ObR protein ve çözünebilir leptin reseptör (sObR) düzeyleri arasındaki ilişkinin değerlendirilmesini amaçlamıştır.Metod: Serum leptin, mide leptin ve serum sObR konsantrasyonları mide kanseri olan 30 erkek hasta ve 25 erkek dispeptik hastada enzimle bağlanmış immünosorbent yöntem ile tayin edildi. Mide ObR seviyeleri, endoskopik olarak elde edilen mide biyopsi örneklerinde Western Blot yöntemi kullanılarak incelendi.Bulgular: Kontroller ile karşılaştırıldığında, hastaların daha düşük serum leptin ve daha yüksek gastrik doku leptin düzeyleri vardı. Hastaların sObR protein konsantrasyonları anlamlı derecede yüksek saptandı, mide ObR protein ekspresyonları kontrol grubundaki bireylere göre daha düşükolarak bulundu.Sonuç: GC'de kanserli bölgede leptin ve dolaşımda sObR aşırı eksprese edilmektedir. Ekspresyonları,kanser ile ilişkilidir. Azalmış leptin düzeyleri, dolaşımdaki sObR sinyalini indükler. Bu negatif geri besleme düzenlemesi ayrıca mide dokusunda da görülür: artmış gastrik doku leptin düzeyleri, mide ObR protein ekspresyonunu inhibe eder. Böylece, leptin ve ObR, GC'de önemli belirteçler olabilir

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Cite This Article

SAVAŞCIHABEŞ, A., KILIÇ, E., ÇAKIR, N., COŞKUN, B. D. Ö., ÇAKIR, I. (2022). Mide kanserinde leptin ve reseptörlerinin (ObR, sObR) ekspresyonları arasındaki korelasyon. Türk Biyokimya Dergisi, Cilt: 41 - Sayı: 4, 243–249. https://ajindex.com/articles/621060

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