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Journals / Türk Biyokimya Dergisi / 2016 / Cilt: 41 - Sayı: 5

Premenopozal kadınlarda 8 haftalık farklı şiddetteki yürüyüş antrenmanlarının insülin direnci ve ER stresiyle ilişkili markerler üzerine etkileri

Effects of two different eight-week walking programs on insulin resistance and ER stressrelated markers in pre-menopausal women

Yeliz DOĞRU
Gürbüz BÜYÜKYAZI
Mehmet GÖRAL
Hakan TIKIZ
Hasan ESEN
Fatma TANELİ
Cevval ULMAN
Pages
322–330
Publication Date
2022-11-05
DOI
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⚡ TL;DR(Too Long; Didn't Read)

Body mass index (BMI), body fat percentage (%), VO2max, serum TNF-?, Fetuin-A, JNK-1, RPB-4, blood lipids, and insulin resistance levels were determined before and after the intervention.Results: VO2max increased in both exercise groups favoring BWG; RBP-4 decreased in both exercise groups (p

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Objective & Hypothesis:Objective: The relationship between exercise and endoplasmic reticulum (ER) stress, insulin resistance, and obesity is a new field of research.
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Key Findings & Data:To examine the effect of two different eight-week walking programs on the tumor necrosis factor-alpha (TNF-?), Fetuin-A (?2 - Heremans Schmid glycoprotein), c-Jun N-terminal kinase-1 (JNK-1) and retinol-binding protein-4 (RBP-4), the related markers of ER stress and insulin resistance in pre-menopausal women.Methods: Exercise groups (moderate tempo walking group; MTWG; n=11; brisk walking group BWG; n=12) walked five days a week, starting from 30 minutes, gradually increasing up to 51 minutes.
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Conclusion & Impact:Body mass index (BMI), body fat percentage (%), VO2max, serum TNF-?, Fetuin-A, JNK-1, RPB-4, blood lipids, and insulin resistance levels were determined before and after the intervention.Results: VO2max increased in both exercise groups favoring BWG; RBP-4 decreased in both exercise groups (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: The relationship between exercise and endoplasmic reticulum (ER) stress, insulin resistance, and obesity is a new field of research. To our knowledge, there are no studies examining the effects of walking exercises on ER stress related markers and insulin resistance in pre-menopausal women. To examine the effect of two different eight-week walking programs on the tumor necrosis factor-alpha (TNF-?), Fetuin-A (?2 - Heremans Schmid glycoprotein), c-Jun N-terminal kinase-1 (JNK-1) and retinol-binding protein-4 (RBP-4), the related markers of ER stress and insulin resistance in pre-menopausal women.Methods: Exercise groups (moderate tempo walking group; MTWG; n=11; brisk walking group BWG; n=12) walked five days a week, starting from 30 minutes, gradually increasing up to 51 minutes. BWG walked at ~70-75% and MTWG at ~50-55 of HRRmax. Body mass index (BMI), body fat percentage (%), VO2max, serum TNF-?, Fetuin-A, JNK-1, RPB-4, blood lipids, and insulin resistance levels were determined before and after the intervention.Results: VO2max increased in both exercise groups favoring BWG; RBP-4 decreased in both exercise groups (p

Özet

Amaç: Egzersiz ile Endoplazmik Retikulum (ER) stresi, insülin direnci ve obezite arasındaki ilişki yeni araştırılan bir alandır. Bilgimiz dahilinde literatürde premenopozal kadınlarda yürüyüş egzersizlerinin, ER stresiyle ilişkili markerler ve insülin direnci ile ilişkisini inceleyen çalışma bulunmamaktadır. Pre-menopozal dönemdeki kadınlarda 8 haftalık farklı şiddette yapılan yürüyüş egzersizlerinin tumor necrosis factor-alpha (TNF?), Fetuin-A (?2 - Heremans Schmid glycoprotein), c-Jun N-terminal kinase-1 (JNK-1) ve retinol-binding protein-4 (RBP-4) gibi ER stresiyle ilgili olabilecek markerler ile insülin direnci üzerine etkisini incelemektir.Metod: Egzersiz grupları (hızlı tempo yürüyüş grubu: HTYG; n=12; orta tempo yürüyüş grubu: OTYG; n=11), haftada beş gün, günde 30 dakikadan başlayarak 51 dakikaya kadar sabit olarak artan sürelerde yürüdüler. HTYG kalp atım sayısı yedeğinin yaklaşık ~%70-75 şiddetinde (hızında), OTYG ise ~%50-55 şiddetinde yürüdü. Egzersiz periyodundan önce ve sonra beden kütle indeksi (BKI), vücut yağ oranı (%), indirekt maksimal oksijen tüketimi (VO2max), serum TNF-?, Fetuin-A, JNK-1, RBP-4, kan lipidleri ve insülin direnci düzeyleri belirlendi.Bulgular: VO2max HTYG'de daha belirgin olmak üzere her iki egzersiz grubunda artarken, RBP-4 düzeyleri her iki egzersiz grubunda anlamlı olarak azaldı (p

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Cite This Article

DOĞRU, Y., BÜYÜKYAZI, G., GÖRAL, M., TIKIZ, H., ESEN, H., TANELİ, F., ULMAN, C. (2022). Premenopozal kadınlarda 8 haftalık farklı şiddetteki yürüyüş antrenmanlarının insülin direnci ve ER stresiyle ilişkili markerler üzerine etkileri. Türk Biyokimya Dergisi, Cilt: 41 - Sayı: 5, 322–330. https://ajindex.com/articles/621056

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