Diabetes mellitus hastalarında adenozin deaminaz aktivitesi ve çinko düzeyleri

We aimed to evaluate serum ADA activity, zinc levels and the relationship between these two parameters in dia-betes mellitus.Methods: We investigated serum ADA activity and zinc levels in type I (n = 100) and type II diabetes mellitus patients (n = 151).Results: ADA activities of diabetic patients were signifi-cantly elevated, whereas zinc levels were significantly lower than those of healthy controls (p 8%) showed significantly increased ADA activity (p 0.05).Conclusion: Elevated ADA activity in diabetic patients with poor glycemic control may be a useful marker for therapy modulation.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective:Adenosinedeaminase(ADA)specificallycatalyzes the deamination of adenosine which has been proved to play an important role in modulation of insulin action on glucose metabolism.

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Key Findings & Data:Zinc is an essential micro-nutrient that is directly involved in the physiology of insulin and may be an important agent to activate the ADA.

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Conclusion & Impact:We aimed to evaluate serum ADA activity, zinc levels and the relationship between these two parameters in dia-betes mellitus.Methods: We investigated serum ADA activity and zinc levels in type I (n = 100) and type II diabetes mellitus patients (n = 151).Results: ADA activities of diabetic patients were signifi-cantly elevated, whereas zinc levels were significantly lower than those of healthy controls (p 8%) showed significantly increased ADA activity (p 0.05).Conclusion: Elevated ADA activity in diabetic patients with poor glycemic control may be a useful marker for therapy modulation.

🔬Design:Research Article

📍Scope:Comprehensive Sample

⚙️Variables:Domain Parameters

Abstract

Objective:Adenosinedeaminase(ADA)specificallycatalyzes the deamination of adenosine which has been proved to play an important role in modulation of insulin action on glucose metabolism. Zinc is an essential micro-nutrient that is directly involved in the physiology of insulin and may be an important agent to activate the ADA. We aimed to evaluate serum ADA activity, zinc levels and the relationship between these two parameters in dia-betes mellitus.Methods: We investigated serum ADA activity and zinc levels in type I (n = 100) and type II diabetes mellitus patients (n = 151).Results: ADA activities of diabetic patients were signifi-cantly elevated, whereas zinc levels were significantly lower than those of healthy controls (p 8%) showed significantly increased ADA activity (p 0.05).Conclusion: Elevated ADA activity in diabetic patients with poor glycemic control may be a useful marker for therapy modulation.

Özet

Amaç: Adenozin deaminaz (ADA) adenozinin deaminasyonunu spesifik olarak katalize eder. Adenozinin, insülin aktivitesi üzerinden glukoz metabolizmasının düzenlenmesinde önemli rol oynadığı bilinmektedir. Çinko ise, insülinin fizyolojisiyle doğrudan ilişkili bir eser elementtir ve ADA'ın aktivasyonunda önemli etkileri olan bir ajan olduğu düşünülmüştür. Çalışmamızda diyabetli hasta gruplarında serum ADA aktivitesini ve çinko düzeylerini ve ADA ile çinko arasındaki ilişkiyi değerlendirmeyi amaçladık.Metod: Çalışmada tip I diabetes mellitusu olan 100 ve tip II diabetes mellitusu olan 151 diyabetli hastadan alınan serum örneklerinde ADA aktivitesi ve çinko düzeyleri çalışıldı.Bulgular: Diyabetli hasta gruplarının ADA değerleri, kontrol grubunun değerlerine göre anlamlı olarak yüksek; çinko değerleri kontrol grubunun değerlerine göre anlamlı olarak düşük bulundu (p 8%), iyi glisemik kontrollü diyabetik olgulara (HbA1c 0.05).Sonuç: Kötü glisemik kontrollü diyabetli hastalardaki yüksek ADA aktivitesi tedavinin düzenlenmesi için faydalı bir belirteç olabilir

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Cite This Article

ŞİRİKÇİ, Ö., HAKLAR, G., BAHADIR, G., TURKAL, R., ERDOĞAN, Y. D., KOLDAŞ, M. (2022). Diabetes mellitus hastalarında adenozin deaminaz aktivitesi ve çinko düzeyleri. Türk Biyokimya Dergisi, Cilt: 41 - Sayı: 6, 423–429. https://ajindex.com/articles/621049

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