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Journals / Türk Biyokimya Dergisi / 2016 / Cilt: 41 - Sayı: 4

Rosa pisiformis’in antioksidant özellikleri ve izoproterenol ile ratlarda oluşturulan okdidatif strese karşı koruyucu etkisi

Antioxidant properties of Rosa pisiformis and its protective effect against isoproterenol-induced oxidative stress in rats

Mahire BAYRAMOĞLU
Fevzi ÖZGÖKÇE
Hatice KIZILTAŞ
Gökhan OTO
Suat EKİN
Ebru ALTINDAL SUSEN
Pages
232–242
Publication Date
2022-11-05
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

P. fruitsin particular can be used to treat and prevent cardiacdiseases.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: In this study, Rosa pisiformis was evaluated for its antioxidant activity, vitamin (A, E, C), trace element (Fe, Cu, Zn, Mn, Cr, Se) and mineral (Ca, K, Mg, Na) levels, in addition to its cardioprotective effects on cardiac tissue antioxidant enzymes (GSH-Px, SOD, CAT) during isoproterenol (ISO) - induced oxidative stress.Methods: In the study, vitamin and mineral analysis was carried out using HPLC and ICP-MS method, R.
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Key Findings & Data:Forty wistar albino rats were divided into four groups: control (0.9% NaCl), ISO (100 mg/kg), ISO (100 mg/kg) + R.
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Conclusion & Impact:P. fruitsin particular can be used to treat and prevent cardiacdiseases.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: In this study, Rosa pisiformis was evaluated for its antioxidant activity, vitamin (A, E, C), trace element (Fe, Cu, Zn, Mn, Cr, Se) and mineral (Ca, K, Mg, Na) levels, in addition to its cardioprotective effects on cardiac tissue antioxidant enzymes (GSH-Px, SOD, CAT) during isoproterenol (ISO) - induced oxidative stress.Methods: In the study, vitamin and mineral analysis was carried out using HPLC and ICP-MS method, R. P. antioxidant and antiradical properties were determined using spectrophotometer. Forty wistar albino rats were divided into four groups: control (0.9% NaCl), ISO (100 mg/kg), ISO (100 mg/kg) + R. P. (300 mg/kg) and R. P. (300 mg/kg). ISO was injected subcutaneously into rats twice at an interval of 24 h for two consecutive days (on 28th and 29th day). R. P. fruit administered daily. The experimental period was continued for 30 days.Results: The results of the study indicated that R. P. fruit and leaves contain high levels of minerals and vitamins and possess antioxidant and antiradical activity and its fruits have positive effects on cardiac tissues. The results are supported with significant changes in antioxidant enzyme levels and histopathological examinationConclusion: This study demonstrates that R. P. fruitsin particular can be used to treat and prevent cardiacdiseases.

Özet

Amaç: Bu çalışmada Rosa pisiformis'in antioksidant aktivite, vitamin (A,E,C), iz element (Fe, Cu, Zn, Mn, Cr, Se) ve mineral (Ca, K, Mg, Na) düzeyleri, bununla birlikte, isoproterenol ile oluşturulan oksidatif stres boyunca, kalp dokusu antioksidan enzimleri (GSH-Px, SOD, CAT) üzerine koruyucu etkileri değerlendirildi.Metod: Çalışmada, vitamin ve mineral analizi HPLC ve ICP-MS metodu kullanılarak gerçekleştirildi. R. P. antioksidant ve antiradikal özellikleri spektrofotometre kullanılarak belirlendi. Kırk wistar albino rat dört guba ayrıldı: Kontrol (0.9% NaCl), ISO (100 mg/kg), ISO (100 mg/kg) + R. P. (300 mg/kg) ve R. P. (300 mg/kg). ISO ratlara 24 saat ara ile 2 gün (28 ve 29. gün) boyunca iki kez subkutan olarak enjekte edildi. R. P. meyvesi günlük olarak uygulandı. Deneysel aşama 30 gün sürdürüldü.Bulgular: Bu çalışmanın sonuçları, R. P. meyve ve yapraklarının yüksek düzeylerde mineral ve vitamin içeriği, antioksidan ve antiradikal aktiviteye sahip olduğu ve meyvelerinin kalp dokusu üzerinde olumlu etkilere sahip olduğunu gösterdi. Bu sonuçlar, antioksidan enzim düzeylerinde ve histopatolojik incelemedeki anlamlı değişiklikler ile desteklendi.Sonuç: Bu çalışma, R. P. meyvesinin özellikle kalp hastalıklarının önlenmesi ve tedavisi için kullanılabileceğini göstermektedir

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Cite This Article

BAYRAMOĞLU, M., ÖZGÖKÇE, F., KIZILTAŞ, H., OTO, G., EKİN, S., SUSEN, E. A. (2022). Rosa pisiformis’in antioksidant özellikleri ve izoproterenol ile ratlarda oluşturulan okdidatif strese karşı koruyucu etkisi. Türk Biyokimya Dergisi, Cilt: 41 - Sayı: 4, 232–242. https://ajindex.com/articles/621042

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