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Journals / Türk Biyokimya Dergisi / 2017 / Cilt: 42 - Sayı: 1

Comparison of high sensitive and conventional troponin assays in diagnosis of acute myocardial infarction

Akut Miyokard Enfarktüsü Tanısında Yüksek Sensitif Ve Konvansiyonel Troponin Testlerinin Karşılaştırılması

Mehmet ERTÜRK
Ömer Faruk BAYCAN
Serkan YAZAN
Mehmet Rıfat YILDIRIM
Murat KOŞER
Begüm ÖZALP
İsmail BIYIK
Nilgün IŞIKSAÇAN
İbrahim Faruk AKTÜRK
Hüseyin KARAKURT
Pages
77–85
Publication Date
2022-11-05
DOI
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⚡ TL;DR(Too Long; Didn't Read)

Troponin levels were measured with chemiluminescence Cobas troponin T assay, immunofluorescence Triage tro­ponin I assay, immunofluorometric Radiometer troponin I assay and immunochromatographic Toyo troponin I assay.Results: Sensitivity and specificity of immunofluoromet­ric assay (Radiometer) are 56.82% and 71.34%; immuno­chromatographic assay (Toyo) are 29.4% and 88.62%, immunofluorescence assay (Triage) are 47.13% and 76.12%, chemiluminescence assay (Roche) are 60.49 and

📌 3 Key Takeaways

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Objective & Hypothesis:Introduction: We aimed to compare the positive predictive values (PPV) and negative predictive values (NPV) of four cardiac troponin assays in the diagnosis of AMI in Turkish population.Methods: This study is an observational comparative study, which is performed between 2012 and 2013 (527 patients).
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Key Findings & Data:Introduction: We aimed to compare the positive predictive values (PPV) and negative predictive values (NPV) of four cardiac troponin assays in the diagnosis of AMI in Turkish population.Methods: This study is an observational comparative study, which is performed between 2012 and 2013 (527 patients).
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Conclusion & Impact:Troponin levels were measured with chemiluminescence Cobas troponin T assay, immunofluorescence Triage tro­ponin I assay, immunofluorometric Radiometer troponin I assay and immunochromatographic Toyo troponin I assay.Results: Sensitivity and specificity of immunofluoromet­ric assay (Radiometer) are 56.82% and 71.34%; immuno­chromatographic assay (Toyo) are 29.4% and 88.62%, immunofluorescence assay (Triage) are 47.13% and 76.12%, chemiluminescence assay (Roche) are 60.49 and
🔬Design:Research Article
📍Scope:2012 Verileri
⚙️Variables:Domain Parameters

Abstract

Introduction: We aimed to compare the positive predictive values (PPV) and negative predictive values (NPV) of four cardiac troponin assays in the diagnosis of AMI in Turkish population.Methods: This study is an observational comparative study, which is performed between 2012 and 2013 (527 patients). Troponin levels were measured with chemiluminescence Cobas troponin T assay, immunofluorescence Triage tro­ponin I assay, immunofluorometric Radiometer troponin I assay and immunochromatographic Toyo troponin I assay.Results: Sensitivity and specificity of immunofluoromet­ric assay (Radiometer) are 56.82% and 71.34%; immuno­chromatographic assay (Toyo) are 29.4% and 88.62%, immunofluorescence assay (Triage) are 47.13% and 76.12%, chemiluminescence assay (Roche) are 60.49 and

Özet

Amaç: Türk popülasyonunda akut miyokard enfarktüsü (AME) tanısında dört kardiyak troponin testinin pozitif ve negatif prediktif değerlerinin (PPD ve NPD) kıyaslanması amaçlanmıştır.Metod: 527 hastadan 2012 ile 2013 yılları arasında gözleme dayalı karşılaştırma çalışması yapılmıştır. Tro­ponin düzeyleri kemilüminesans Cobas troponin T testi, immünfloresans Triage troponin I testi, immünfloromet­rik Radiometer troponin I testi ve immünkromatografik Toyo troponin I testi ile ölçülmüştür.Bulgular: Sensitivite ve spesifisite değerleri sırasıyla Radio­meter immünflorometrik test için % 56.82 ve % 71.34; Toyo immünkromatografik test için % 29.4 ve % 88.62; Triage immünfloresans test için % 47.13 ve % 76.12; Roche Cobas kemilüminesans test için ise % 60.49 ve % 67.42 olarak saptanmıştır. PPD, NPD ve pozitif olabilirlik oranı sırasıyla Radiometer immünflorometrik test için % 45.5, % 79.7 ve 1.98; Toyo immünkromatografik test için % 51.5, % 75.4 ve 2.58; Triage immünfloresans test için % 46.5, % 76.6 ve 1.97; Roche Cobas kemilüminesans test için % 45.8%, 78.9% and 1.86 olarak hesaplanmıştır. Dört metodun troponin değerleri AME pozitif hastalarda negatiflere göre istatistik­sel olarak anlamlı yüksektir. (herbiri için p < 0.001).Sonuç: AME tanısında tüm metodların PPD ve NPD kıyas­lamasında istatistiksel olarak anlamlı bir fark bulunma­mış olup, Triage ve Toyo metodlarının düşük sensitivite değerleri gözönünde bulundurulmalıdır

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Cite This Article

ERTÜRK, M., BAYCAN, Ö. F., YAZAN, S., YILDIRIM, M. R., KOŞER, M., ÖZALP, B., BIYIK, İ., IŞIKSAÇAN, N., AKTÜRK, İ. F., KARAKURT, H. (2022). Comparison of high sensitive and conventional troponin assays in diagnosis of acute myocardial infarction. Türk Biyokimya Dergisi, Cilt: 42 - Sayı: 1, 77–85. https://ajindex.com/articles/621009

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