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Journals / Türk Biyokimya Dergisi / 2018 / Cilt: 43 - Sayı: 2

Effects of chemoradiotherapy on acute-phase protein levels in glioblastoma multiforme and locally advanced non-small cell lung cancer

Glioblastoma multiforme ve lokal ileri evre küçük hücreli dışı akciğer kanserinde kemoradyoterapinin akut faz protein seviyelerine etkisi

Mehmet GÜRBİLEK
Çiğdem Damla DENİZ
Mehmet KOÇ
Pages
159–166
Publication Date
2022-11-05
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Bearing in mind their accessibility andclinical value, plasma CRP and FER in NSCLC patients andCp in GBM patients can be considered candidate prognosticfactors.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Chemoradiotherapy (CRT) is a commonly usedtherapeutic modality.
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Key Findings & Data:The aim of this study wasto assess possible changes in APR levels during radiotherapyand to determine the usefulness of APRs as prognosticfactors in patients with non-small cell lung cancer(NSCLC) and glioblastoma multiforme (GBM).Methods: We prospectively evaluated 30 patients and30 healthy controls.
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Conclusion & Impact:Bearing in mind their accessibility andclinical value, plasma CRP and FER in NSCLC patients andCp in GBM patients can be considered candidate prognosticfactors.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: Chemoradiotherapy (CRT) is a commonly usedtherapeutic modality. We investigated CRT effects onacute phase reactants (APRs). The aim of this study wasto assess possible changes in APR levels during radiotherapyand to determine the usefulness of APRs as prognosticfactors in patients with non-small cell lung cancer(NSCLC) and glioblastoma multiforme (GBM).Methods: We prospectively evaluated 30 patients and30 healthy controls. Plasma levels of APRs were measured.Post-CRT and pre-CRT levels were compared. Survival ofpatients were also followed up for a period of 3 years.Results: In NSCLC patients, post-CRT albumin, transferrin(Trf), and ceruloplasmin (Cp) levels were significantlylower, and post-CRT ferritin (FER) levels were significantlyhigher, than their pre-CRT levels. In GBM patients, post-CRT Trf and prealbumin (Prealb) levels were significantlyhigher than pre-CRT levels. Pre-CRT C-reactive protein(CRP) and FER levels in NSCLC patients and Cp levels inGBM patients were associated with patient survival.Conclusion: This study suggests that APRs may be usefulfor monitoring response to treatment during CRT in NSCLCand GBM patients. Bearing in mind their accessibility andclinical value, plasma CRP and FER in NSCLC patients andCp in GBM patients can be considered candidate prognosticfactors.

Özet

Amaç: Kemoradyoterapi (KRT) sık kullanılan bir tedavi yöntemidir. KRT’nin akut faz reaktanları (AFR) üzerindeki etkilerini araştırdık. Bu çalışmanın amacı, radyoterapi sırasında AFR düzeylerindeki olası değişiklikleri değerlendirmek ve küçük hücreli dışı akciğer kanseri (KHDAK) ve glioblastoma multiforme (GBM) hastalarında prognostik faktör olarak AFR’lerin kullanılabilirliğini belirlemektir. Metod: Prospektif olarak 30 hasta ve 30 sağlıklı kontrol değerlendirildi. AFR’lerin plazma seviyeleri ölçüldü. Post- KRT ve pre-KRT seviyeleri karşılaştırıldı. Hastaların sağkalımı da 3 yıllık bir süre boyunca takip edildi. Bulgular: KHDAK hastalarında; pre-KRT seviyeleri ile karşılaştırıldığında post-KRT albümin, transferrin (Trf), ve seruloplasmin (Cp) düzeyleri anlamlı derecede düşük ve post-KRT ferritin (FER) düzeyleri anlamlı derecede yüksek bulunmuşdur. GBM hastalarında; Post-KRT Trf ve prealbümin (Prealb) düzeyleri KRT öncesi düzeyler ile kıyaslandığında anlamlı derecede yüksekti. KHDAK hastalarında pre-KRT C-reaktif protein (CRP) ve FER düzeyleri ve GBM hastalarında Cp düzeyleri hasta sağkalımı ile ilişkilendirildi. Sonuç: Bu çalışma, AFR’larının KHDAK ve GBM’li hastalarda KRT sırasında tedaviye yanıtın izlenmesi için yararlı olabileceğini düşündürmektedir. Erişilebilirlik ve klinik değeri göz önüne alındığında, KHDAK hastalarında plazma CRP ve FER, GBM hastalarında Cp aday prognostik faktörler olarak düşünülebilir.

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Cite This Article

GÜRBİLEK, M., DENİZ, Ç. D., KOÇ, M. (2022). Effects of chemoradiotherapy on acute-phase protein levels in glioblastoma multiforme and locally advanced non-small cell lung cancer. Türk Biyokimya Dergisi, Cilt: 43 - Sayı: 2, 159–166. https://ajindex.com/articles/620985

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