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Journals / Türk Biyokimya Dergisi / 2018 / Cilt: 43 - Sayı: 2

Meta-analysis of the relationship between MnSOD polymorphism and cancer in the Turkish and Cypriot population

MnSOD polimorfizmi ile kanser arasındaki ilişkinin Türk ve Kıbrıs toplumundaki meta analizi

Cumhur GUNDUZ
Tuğçe BALCI
Pages
184–196
Publication Date
2022-11-05
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The A/V genotypepolymorphism was found be significant for cancer.Conclusion: The frequency of the A/V heterozygote genotypeof the MnSOD polymorphisms is found to be higherin the Cypriot and Turkish populations than any othergenotype.

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: The association between manganese superoxidedismutase (MnSOD) p.Val16Ala polymorphism andcancer has been shown in various studies.
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Key Findings & Data:The aim of thisstudy is to investigate the relationship between MnSODpolymorphism (V/V, V/A, A/A) and cancer in the Turkishand Cypriot population through meta-analysis.Material and methods: The present study included metaanalysisof 14 publications covering 2413 cancer patientsand 2907 healthy control groups from 2005 to 2016.
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Conclusion & Impact:The A/V genotypepolymorphism was found be significant for cancer.Conclusion: The frequency of the A/V heterozygote genotypeof the MnSOD polymorphisms is found to be higherin the Cypriot and Turkish populations than any othergenotype.
🔬Design:Lab & Field Experiment
📍Scope:2005 Verileri
⚙️Variables:Domain Parameters

Abstract

Objectives: The association between manganese superoxidedismutase (MnSOD) p.Val16Ala polymorphism andcancer has been shown in various studies. The aim of thisstudy is to investigate the relationship between MnSODpolymorphism (V/V, V/A, A/A) and cancer in the Turkishand Cypriot population through meta-analysis.Material and methods: The present study included metaanalysisof 14 publications covering 2413 cancer patientsand 2907 healthy control groups from 2005 to 2016. Pooledodds ratio (OR) and 95% confidence interval (CI) were calculatedusing the random effect model of DerSimonianand Laird for each study. Publication bias was checkedwith funnel plot by Begg’s and Egger’s test statistics.Results: Meta-analysis of MnSOD polymorphism was performedin the additive model (AV vs. VV; OR = 1.133, 95%CI: 1.002–1.282), allele contrast (A vs. V; OR = 1.016, 95%CI: 0.930–1.278), homozygote model (AA vs. VV; OR = 0.983,95% CI: 0.839–1.153), dominant model (AA + AV vs. VV;OR = 1.090, 95% CI: 0.971–1.223) and recessive model (AA vs.AV + VV; OR = 0.924, 95% CI: 0.803–1.064). The A/V genotypepolymorphism was found be significant for cancer.Conclusion: The frequency of the A/V heterozygote genotypeof the MnSOD polymorphisms is found to be higherin the Cypriot and Turkish populations than any othergenotype.

Özet

Amaç: Çalışmalarda mangan süperoksit dismutaz (MnSOD) p.Val16Ala polimorfizmi ile kanser arasındaki ilişki gösterilmiştir. Bu çalışmanın amacı, meta-analizle Türk ve Kıbrıs toplumundaki MnSOD polimorfizmi (V/V, V/A, A/A) ve kanser arasındaki ilişkiyi araştırmaktır. Gereç ve Yöntem: Bu çalışma, 2005-2016 yılları arasındaki 2413 kanser hastasını ve 2907 sağlıklı kontrol grubunu kapsayan 14 araştırmanın meta-analizini içermektedir. Her bir çalışma için odds oranı (OR) ve % 95 güven aralığı (CI) değerleri Dersimonian ve Laird’nin tesadüfi etki modeli kullanılarak belirlendi. Yayın yanlılığı, Begg ve Egger’ in test istatistiklerine göre funnel plot ile kontrol edildi. Bulgular: MnSOD polimorfizminin meta analizi, additif model (AV vs. VV: OR = 1,133, % 95 CI: 1,002–1,282), alel kontrast (A vs. V; OR = 1,016, % 95 CI: 0,930–1,278), homozigot model (AA vs. VV; OR = 0,983, % 95 CI: 0,839–1,153) dominant model (AA + AV vs. VV; OR = 1,090, % 95 CI: 0,971–1,223)ve resesif model (AA vs. AV + VV; OR = 0,924, % 95 CI: 0,803–1,064) olarak yapıldı. A/V genotip polimorfizmi kanser için önemli olduğu bulundu. Sonuç: MnSOD polimorfizminin A/V heterozigot genotip sıklığı, Kıbrıs ve Türk popülasyonlarında diğer genotiplerden daha yüksek bulunmuştur.

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Cite This Article

GUNDUZ, C., BALCI, T. (2022). Meta-analysis of the relationship between MnSOD polymorphism and cancer in the Turkish and Cypriot population. Türk Biyokimya Dergisi, Cilt: 43 - Sayı: 2, 184–196. https://ajindex.com/articles/620929

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