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Journals / Türk Biyokimya Dergisi / 2019 / Cilt: 44 - Sayı: 5

Fibrinopeptide-A and fibrinopeptide-B may help to D-dimer as early diagnosis markers for acute mesenteric ischemia

Fibrinopeptid-A ve Fibrinopeptid-B, Akut Mesenterik İskemi Erken Tanı Belirteçleri Olarak D-Dimere Yardımcı Olabilir

Murat CİKOT
Pınar KASAPOĞLU
Osman KONES
Eyup GEMİCİ
Sinan BİNBOĞA
Elif BİNBOĞA
Halil ALİS
Nilgün IŞIKSAÇAN
Bahadır KARTAL
Pages
654–660
Publication Date
2022-11-05
DOI
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⚡ TL;DR(Too Long; Didn't Read)

The statistical change between 0, 1, 3 and 6 h was more significant for fibrinopeptide-A and fibrinopeptide-B.Conclusion: Fibrinopeptide-A and fibrinopeptide-B may be markers that can be used for early diagnosis of mesenteric ischemia, early diagnosis is highly important for decreasing mortality and morbidity.

📌 3 Key Takeaways

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Objective & Hypothesis:AbstractBackground: The aim of this study was to investigate the importance of fibrinopeptide-A and fibrinopeptide-B, which occur during the formation of D-dimer, the mostcommonly used laboratory parameter, in the early diagnosis of acute mesenteric ischemia (AMI).Materials and methods: This experimental study was performed in 30 male pathogen-free Wistar albino rats.
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Key Findings & Data:The experimental animals were divided into 3 equal groups:Control group (n = 10), Sham group (n = 10) and Ischemia group (n = 10).
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Conclusion & Impact:The statistical change between 0, 1, 3 and 6 h was more significant for fibrinopeptide-A and fibrinopeptide-B.Conclusion: Fibrinopeptide-A and fibrinopeptide-B may be markers that can be used for early diagnosis of mesenteric ischemia, early diagnosis is highly important for decreasing mortality and morbidity.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

AbstractBackground: The aim of this study was to investigate the importance of fibrinopeptide-A and fibrinopeptide-B, which occur during the formation of D-dimer, the mostcommonly used laboratory parameter, in the early diagnosis of acute mesenteric ischemia (AMI).Materials and methods: This experimental study was performed in 30 male pathogen-free Wistar albino rats. The experimental animals were divided into 3 equal groups:Control group (n = 10), Sham group (n = 10) and Ischemia group (n = 10). Blood samples were taken 0, 1, 3, and 6 h after the simulation of mesenteric ischemia.Results: Fibrinopeptide-A and fibrinopeptide-B levels increased significantly in the first 6 h in the ischemic group, similar to the increase in D-dimer levels. The statistical change between 0, 1, 3 and 6 h was more significant for fibrinopeptide-A and fibrinopeptide-B.Conclusion: Fibrinopeptide-A and fibrinopeptide-B may be markers that can be used for early diagnosis of mesenteric ischemia, early diagnosis is highly important for decreasing mortality and morbidity.

Özet

ÖZAmaç: Bu çalışmanın amacı akut mesenterik iskeminin erken tanısında en sık kullanılan laboratuvar parametresi olan D-dimerin oluşumu sürecinde ortaya çıkan Fibrinopetid-A ve Fibrinopeptid-B’ nin önemini araştırmaktır.Gereç ve Yöntem: Bu deneysel çalışma 30 erkek-patojen içermeyen Wistar-albino sıçanda gerçekleştirildi. Deney hayvanları; Kontrol grubu (n = 10), Sham grubu (n = 10) ve İskemi grubu (n = 10) olmak üzere 3 eşit gruba ayrıldı. Kan örnekleri mezenterik iskemi uyarımından 0, 1, 3 ve 6 saat sonra alındı.Bulgular: İskemi grubunda ilk 6 saatte Fibrinopeptid-A ve Fibrinopeptid-B düzeyleri D-dimer seviyesindeki artışa benzer şekilde anlamlı olarak arttı. 0., 1., 3., ve 6. saatler arasındaki istatistiksel değişim, daha anlamlı tespit edildi.Sonuç: Erken tanı mortalite ve morbiditeyi azaltmada çok önemlidir, Fibrinopeptid-A ve Fibrinopeptid-B mezenterik iskemi erken tanısında kullanılabilecek belirteçler olabilir.

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Cite This Article

CİKOT, M., KASAPOĞLU, P., KONES, O., GEMİCİ, E., BİNBOĞA, S., BİNBOĞA, E., ALİS, H., IŞIKSAÇAN, N., KARTAL, B. (2022). Fibrinopeptide-A and fibrinopeptide-B may help to D-dimer as early diagnosis markers for acute mesenteric ischemia. Türk Biyokimya Dergisi, Cilt: 44 - Sayı: 5, 654–660. https://ajindex.com/articles/620903

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References (20)

  1. Scheider TA, Longo WE, Ure T, Verrnava AM. Mesenteric ischemia: acute arterial syndromes. Dis Colon Rectum 1994;37:1163–74
  2. Yasuhara H. Acute mesenteric ischemia: the challenge of gastroenterology. Surg Today 2005;35:185–95
  3. Wilson C, Gupta R, Gilmour DG, Imrie CW. Acute superior mesenteric ischemia. Br J Surg 1987;74:279–81
  4. Lobo-Martinez E, Merono CE, Sacco O, Martinez ME. Embolectomy in mesenteric ischemia. Rev Esp Enferm Dig 1993;83:351–4
  5. Kaleya RN, Boley SJ. Acute mesenteric ischemia. Crit Care Clin 1995;11:479–512
  6. Brandt LJ, Boley SJ. AGA technical review on intestinal ischemia. Gastroenterology 2000;118:954–68
  7. Bassiouny HS. Nonocclusive mesenteric ischemia. Surg Clin North Am 1997;77:319–26
  8. Reilly PM, Bulkley GB. Vasoactive mediators and splanchnic perfusion. Crit Care Med 1993;21:55–68
  9. Kim EH, Gewertz BL. Chronic digitalis administration alters mesenteric vascular reactivity. J Vasc Surg 1987;5:382–9
  10. Coskun A, Halici Z, Oral A, Bayir Y, Deniz F, Caycı T, et al. The value of combined elevation of D-dimer and neopterin as a predictive parameter for early stage acute mesenteric ischemia: an experimental study. Vascular 2017;25:163–9
  11. Pierrakos C, Vincent JL. Sepsis biomarkers: a review. Crit Care 2010;14:R15
  12. Demir IE, Ceyhan GO, Friess H. Beyond lactate: is there a role for serum lactate measurement in diagnosing acute mesenteric ischemia? Dig Surg 2012;29:226–35
  13. Cakir M, Yildirim D, Sarac F, Donmez T, Mirapoglu S, Hut A, et al. In the experimental model of acute mesenteric ischemia, the correlation of blood diagnostic parameters with the duration of ischemia and their effects on choice of treatment. J Invest Surg 2018;31:1–8
  14. John AS, Tuerff SD, Kerstein MD. Nonocclusive mesenteric infarction in hemodialysis patients. J Am Coll Surg 2000;190:84–8
  15. Tripodi A. D-dimer testing in laboratory practice. Clin Chem 2011;57:1256–62
  16. Solak ZA, Telli CG, Kabaroglu C, Dogan B, Bayindir U, Erdener D, et al. Pulmoner Emboli Tanisinda D-Dimer Testinin Yeri. Solunum Hastalıklari 2003;14:11–6
  17. Wakai A, Gleeson A, Winter D. Role of fibrin D dimer testing in emergency medicine. Emerg Med J 2003;20:319–25
  18. Oltean M, Olausson M. The Chiu/Park scale for grading intestinal ischemia-reperfusion: if it ain’t broke don’t fix it! Intensive Care Med 2010;36:1095
  19. Batellier J, Keny R. Superior mesenteric artery embolism eightytwo cases. Ann Vasc Surg 1990;4:112–6
  20. Boley SJ, Feinstein FR, Sammartano R,