Cofilin-1 as a potential biomarker to evaluate acute kidney injury

In this mini-review, we summarized the current knowledge and concepts both in the literature and our experiences with cofilin-1 as a potential biomarker for the diagnosis and management of AKI.

📌 3 Key Takeaways

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Objective & Hypothesis:Abstract: Acute kidney injury (AKI) is a worldwide health problem and defined by rapid loss of excretory function of the kidney with the accumulation of metabolic end products.

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Key Findings & Data:One of the new promising biomarker candidates of renal injury is cofilin-1.

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Conclusion & Impact:In this mini-review, we summarized the current knowledge and concepts both in the literature and our experiences with cofilin-1 as a potential biomarker for the diagnosis and management of AKI.

🔬Design:Review & Systematic Survey

📍Scope:Comprehensive Sample

⚙️Variables:Domain Parameters

Abstract

Abstract: Acute kidney injury (AKI) is a worldwide health problem and defined by rapid loss of excretory function of the kidney with the accumulation of metabolic end products. For effective treatment and prevent complications the early diagnosis of AKI is crucial. The current analytes used to diagnose AKI are not adequately sensitive and specific and therefore clinicians need new biomarkers. One of the new promising biomarker candidates of renal injury is cofilin-1. Previously, in our laboratory we isolated cofilin-1 in kidney preservation solution prior to transplantation and attempted to measure serum cofilin-1 in renal transplanted patients. However, cofilin-1 was not accurately measured in serum samples due to the methodological issues. In this mini-review, we summarized the current knowledge and concepts both in the literature and our experiences with cofilin-1 as a potential biomarker for the diagnosis and management of AKI.

Özet

Akut böbrek hasarı dünya genelinde yaygın görülen bir sağlık sorunudur ve metabolik son ürünlerin birikimi ile böbreğin boşaltım işlevini hızlı bir şekilde kaybetmesiyle nitelendirilmektedir. Etkin tedavi ve komplikasyonları önlemek için akut böbrek hasarının erken teşhisi önemlidir. Akut böbrek hasarını teşhis etmek için kullanılan mevcut analitler yeterince hassas ve özgün değildir. Bu nedenle klinisyenlerin yeni biyobelirteçlere ihtiyacı vardır. Böbrek hasarı için umut veren yeni biyobelirteç adaylarından biri cofilin-1’dir. Daha önce laboratuvarımızda, transplantasyon öncesi böbrek koruma solüsyonunda cofilin-1 proteinini izole ettik ve böbrek nakli yapılan hastalarda serum cofilin-1 proteinini ölçmeye çalıştık. Ancak, serum örneklerinde cofilin-1 proteini metodolojik problemlerden dolayı doğru olarak ölçülmedi. Bu mini derlemede, akut böbrek hasarının teşhisi ve tedavisi için cofilin-1 ile ilgili hem literatür bilgisini hem de kendi deneyimlerimizi özetledik.

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Cite This Article

ÖZPINAR, A., ÜNSAL, İ., SERTESER, M., BERBER, İ., ÇAKIR, Ü., YOZGATLI, T. K., UÇAL, Y., ÇOŞKUN, A., MOLDUR, D. E., DERELİOĞLU, E. İ. (2022). Cofilin-1 as a potential biomarker to evaluate acute kidney injury. Türk Biyokimya Dergisi, Cilt: 44 - Sayı: 1, 9–15. https://ajindex.com/articles/620900

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